Dr David Sinclair’s landmark research in 2013 showed that supplementation to increase NAD+ levels resulted in old mice having the muscles of young mice.
Since then dozens of studies have demonstrated numerous health benefits from increased NAD+ levels in mice.
Supplementation with NAD+ precursors such as Nicotinamide Riboside (Niagen) and Nicotinamide Mono Nucleotide (NMN) has been proven to increase NAD+ in humans, and research is ongoing to determine the health benefits.
INCREASED NAD+ HELPS, BUT IS NOT THE ANSWER BY ITSELF
As we age, NAD+ levels drop. You also need to address the REASON your NAD+ levels drop in the first place.
- heart disease
- inflammatory bowel disease
- periodontal disease
It’s “an ergerging field,” says UCLA’s Dr. David Heber. “It’s a new concept for medicine.” (1)
Arthritis is inflammation of the joints. Heart disease is inflammation of the arteries.
Instead of taking pills that temporarily lessen the symptoms, with better nutrition and exercise we can dramatically lower the inflammation that is the root cause for many of our illnesses.
INFLAMMATION IMPACTS KEY MARKERS OF BIOLOGICAL AGE
This research paper examined 60,000 blood samples to design a deep neural network (DNN) to predict chronological age based on commonly used blood test. Matching biological age from the blood test they determined the 2 most important markers for age were:
read more about inflammation and aging here.
AS WE AGE, INFLAMMATION INCREASES AND DESTROYS NAD+
This Study by Dr Sinclair demonstrates that as we age, inflammation triggers an increase in CD38 that is the main enzyme in the degradation of NAD+.
More inflammation consumes more NAD+. Less NAD+ results in increased inflammation and disease.
DECREASED NAD+ LEVELS AS WE AGE IMPLICATED AS KEY FACTOR IN AGING
As we age our levels of NAD+ drop significantly (1). NAD+ is used to repair damage to cells and fight disease.
INCREASED NAD+ LEVELS BEING RESEARCHED AS TREATMENT FOR VARIOUS CANCERS
Researchers are very interested in the role NAD+ plays in providing healthy mitochondria the means to fight cancer tumors.
Increased mitochondrial NAD+ levels and SIRT3 activity could be a promising strategy for abolishing the development of TICs as a new therapeutic approach to treating aging-associated tumors.
YOUR GOAL – LOWER INFLAMMATION AND INCREASE NAD+ LEVELS
Anti-Inflammatory supplements DO help. But its a little like throwing snipers out on the battlefield to shoot at tanks. As we age, inflammation gets the upper hand and we need more weapons.
Likewise, supplementation with Niagen does raise NAD+ levels, with many people reporting having more energy, motivation, less brain fog, and many other positive benefits.
But you need to do more.
In Dr Sinclair’s research on NAD+ and CD38 mentioned above, he concluded:
These findings suggest that the efficacy of NAD+ precursors may be enhanced by co-supplementation with CD38 inhibitors
He has also said that combining NAD+ boosters and anti-inflammatory supplements will possibly be the future for anti-aging research.
LEARN ABOUT THE CAUSES OF CHRONIC INFLAMMATION AND WHAT YOU CAN DO
- 4 hours a week adds 3 years to lifespan
- Each hour spent exercising adds 7 hours to lifespan
- HIIT is more effective at reversing aging
- Sitting 8 hours a day cuts 2 years off lifespan
High Intensity Interval Training is far more effective at lowering inflammation, especially among older adults.
- Fat cells secret cytokines that promote inflammation
- Insulin Resistance is also linked to increased systemic inflammation
- Anti-Inflammatory foods
- Pro-Inflammatory foods
- Anti-Inflammatory Herbs and Supplements
- Intermittent fasting decreases systemic inflammation
- Advanced Glycation End Products (AGEs) are Super Inflammatory agents
- Fish Oil
These are some of the most highly recommended anti-inflammatories that many people find useful and can help you get even better results with Nicotinamide Riboside
YOU CAN HAVE THE HEALTH AND ENERGY YOU HAD 10 or 20 YEARS AGO!
Yes, a bold statement, but I truly believe it is possible for most people.
It’s not as simple as a magic pill. It takes work and discipline. But you will feel better every day that you stick with it.
It’s also not the result of any one great breakthrough, but taking advantage of the great strides research on healthy aging has made in the last few years.
Our experience has shown that if you put these all together you can have the health and youthful vitality you enjoyed 10 or even 20 years ago.