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Is Basis by Elysium Health a Hoax?

The main ingredient in Elysium Health’s Basis is Nicotinamide Riboside.

Elysium Health is only one of several companies selling Nicotinamide Riboside. Their main selling point is the 6 Nobel Prize winning scientists they have signed up as advisors to their company.

However, these scientists have had no significant role in researching or creating the Nicotinamide Riboside or the Pterostilbene they combine with it to form their Basis product.

WHY BASIS – IS IT BETTER THAN OTHER BRANDS OF NICOTINAMIDE RIBOSIDE?

You won’t find any mention of Niagen in the sales and marketing literature about Basis.

Elysium would like you to think that Basis is some exclusive formula created by their founders.

In fact, until recently, they purchased Nicotinamide Riboside AND Pterostilbene from Chromadex like several other brands.

In mid 2017, a nasty lawsuit between Chromadex and Elysium Health resulted in a new formulation for Basis that uses Nicotinamide Riboside they manufacture themselves.

Conclusion: There is no reason to believe Basis is any more effective than any other Nicotinamide Riboside.

SUPPLEMENTS TO RESTORE NAD+

NMN is not patented and is available to purchase from several different brands. Both Elysium Health and Chromadex market NR capsules.

All have shown great promise in research with mice. While we are still awaiting publication of the first studies of humans with NMN supplements, research has shown NR is effective at elevating NAD+ levels in humans.

However, it is a question if oral supplementation with NAD+ precursors will result in some of the same health benefits demonstrated in studies with mice.

Dr Sinclair’s 2013 study used IP Injections to deliver NMN directly to the bloodstream, enabling it to reach tissues throughout the body more effectively.

In the most recent study by Dr Sinclair, they put NMN in the drinking water of mice at a dosage of 400 mg per kg of bodyweight. This would equate to several grams per day in humans and be extremely expensive.

Limited bioavailability of oral supplements is a big problem. Recent research confirms that oral supplementation of NR and NMN is subject to digestion and first pass metabolism in the liver. Very little actually makes it outside the liver to reach other tissues directly.

SUBLINGUAL DELIVERY

Injections are not feasible for most people, so a more effective delivery method is needed. Introduced in late 2017, a popular option is a Pure NMN powder that users take under the tongue (Sublingually) where it is quickly absorbed directly into the bloodstream, avoiding the digestive system entirely.

Soon you will also be able to purchase a fast dissolve tablet designed for sublingual administration, providing the same benefits as the pure powder, in a more convenient form.

THE PROBLEM with CAPSULES – DIGESTED IN STOMACH

It has also long been suspected that most NR is digested to NAM in the Gastro-Intestinal tract intact (r).

More recently, this research published in 2018 confirms that most oral supplements of NMN and NR are digested to NAM in the GI tract or the liver.

Future pharmacological and nutraceutical efforts to boost NAD will need to take into account the minimal oral bioavailability of NR and NMN (R)

We also showed that intravenous, but not oral administration of NR or NMN delivered intact molecules to multiple tissues (R)

Unlike in cell culture where NR and NMN are readily incorporated into NAD, oral administration fails to deliver NR or NMN to tissues (R)

Interestingly, we found that neither compound was able to enter the circulation intact in substantial quantities when delivered orally (R)

The most recent studies showing tremendous health benefits with NMN were accomplished by feeding mice very large dosages of NMN in water (r). However the dosage of 300-400 mg per kg of bodyweight used in many of these studies would equate to approximately 2,000 Mg per day for a 70 kg human. A more effective delivery method is needed !

SUBLINGUAL VS CAPSULES

Sublingual (under the tongue) delivery can provide rapid absorption via the blood vessels under the tongue rather than via the digestive tract. (r,r)

The absorption of the different molecules delivered through the sublingual route can be 3 to 10 times greater than oral route and is only surpassed by direct IV injection (r).

SUBLINGUAL CAN BE MORE BIOAVAILABLE THAN INJECTION !

With intraperitoneal injection, the primary route of absorption is via the mesenteric vessels, which drain into the portal vein and pass through the liver before reaching the bloodstream.

This means, IP avoids the GI tract, but is still sent directly to the Liver, where much of it is converted to NAD+. Elevated NAD+ in the liver is good, but its far better to reach the bloodstream with intact NMN.

Sublingual delivery is not filtered by the Liver and can reach systemic circulation intact, so can actually result in greater bioavailability that direct injection! Some examples are:

  • A sublingual formulation of zol… exhibited a faster rate of absorption and higher drug exposure as compared to subcutaneous injection (r)
  • sublingually administered epin… results in more rapid absorption and a higher peak plasma concentration compared to injected epin… .(r)
  • 40mg of sublingually administered pir.. was found to be as effective as a 75 mg intramuscular injection of dicl… (r)

NMN PERFECT FOR SUBLINGUAL

Depending on the molecule, Sublingual delivery can substantially improve the speed and bioavailability. Smaller molecules that are hydrophilic such as NMN are well-suited.

a drug which has been formulated for sublingual should ideally have a molecular weight of less than 500 (r)

NMN is very hydrophilic, with a molecular weight of 324, making it a perfect fit for sublingual delivery.

New research shows that NMN and NR are mostly digested to Nicotinamide when taken as oral supplements (r). Sublingual delivery of small, hydrophilic molecules such as NMN bypass the digestive system and can be quickly absorbed to the bloodstream making it far more bioavailable than capsules.

CONCLUSION

Elysium Health produces a top quality product, and is a very reputable company.

However, they did not develop Nicotinamide Riboside and there is no evidence the addition of Pterostilbene makes their Basis product any more effective.

The distinguished scientists on their advisory board lend great credibility to the reputation of the company and are a great advantage for marketing purposes.

REFERENCES:

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