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Is Basis by Elysium Health a Hoax?

The main ingredient in Elysium Health’s Basis is Nicotinamide Riboside.

Elysium Health is only one several companies selling Nicotinamide Riboside. Their main selling point is the 6 Nobel Prize winning scientists they have signed up as advisors to their company.

However, these scientists have had no significant role in researching or creating the Nicotinamide Riboside or the Pterostilbene they combine to form their Basis product.

WHY BASIS – IS IT BETTER THAN OTHER BRANDS OF NICOTINAMIDE RIBOSIDE?

You won’t find any mention of Niagen in the sales and marketing literature about Basis.

Elysium would like you to think that Basis is some exclusive formula created by their founders.

In fact, until recently, they purchased Nicotinamide Riboside AND Pterostilbene from Chromadex like several other brands.

In mid 2017, a nasty lawsuit between Chromadex and Elysium Health resulted in a new formulation for Basis that uses Nicotinamide Riboside they manufacture themselves.

Conclusion: There is no reason to believe Basis is any more effective than any other Nicotinamide Riboside.

NMN A MORE EFFECTIVE NAD+ BOOSTER?


Elysium Health and Chromadex are spending MILLIONS of dollars a month battling over the patent rights of Nicotinamide Riboside (NR).

Meanwhile, NMN (Nicotinamide Mononucleotide) is a NON PATENTED supplement that is now becoming available at an affordable price that is very likely to prove more effective for health and Anti-Aging.

Two things to keep in mind:

  • NR MUST convert to NMN in the body BEFORE it can become NAD+
  • NMN is found freely circulating in the bloodstream
  • NR is normally NOT FOUND in the bloodstream, even after massive dosages

So, why is Basis and Nicotinamide Riboside more well known than NMN? The fact it is patented, so the price and supply can be controlled allows for huge profit margins that can be plowed into advertising is surely a major factor.

Read more about NMN here

NAD+ is the key for Healthy Aging

As we age, our levels of the Co-enzyme Nicotinamide Adenine Dinucleotide NAD+ drop significantly in multiple organs in mice and humans (5, 8, 10).

NAD+ is a key Co-enzyme used by our mitochondria for energy production in all our cells. Higher NAD+ levels are needed for our cells to function at their best.

NAD+ decrease is described as a trigger in age-associated decline(23), and perhaps even the key factor in why we age (5).

Elevating NAD+ with Supplements

In 2013, research published by Dr David Sinclair demonstrated that short term supplementation with Nicotinamide MonoNucleotide (NMN) replenished NAD+ and reversed many aspects of aging, making the cells of old mice resemble those of much younger mice, and greatly improving their health (8).

NMN was able to mitigate most age-associated physiological declines in mice.

Treatment of old mice with NMN reversed all of these biochemical aspects of aging.

HUMAN NAD+ METABOLISM

NAD+ is constantly being consumed and replenished through the Salvage Pathway, with approximately 3g of NAM metabolized to NMN and then to NAD+ 2-4 times per day (14).

  • The salvage pathway sustains 85% or more of our NAD+ (14)
  • Nampt is the rate-limiting step in the salvage process (97).
  • As we age, Nampt enzyme activity is lower, resulting in less NAM recycling, less NAD+, more disease and aging (97, 101).

NR AND NMN BYPASS THE NAMPT BOTTLENECK

NMN is the immediate precursor to NAD+, and is after Nampt in the salvage process, so NMN bypasses the Nampt bottleck

In 2004 Dr Charles Brenner published a paper showing that the enzyme Nrk1 can catalyze NR directly to NMN (100), which means that any NR that makes it’s way into the bloodstream can theoretically bypass the NAMPT bottleneck.

Although NR is unstable by itself, Dartmouth University has patented production methods that combine it with Chloride which makes it stable outside the body

Chromadex has licensed this technology and has been selling NR commercially since 2014 under the brand name “Niagen”.

Tru Niagen is the brand name used by Dr Brenner’™s company ProHealthSpan to market their Niagen product.

Digested to NAM

When taken orally as a supplement, most NR does not make it through the digestive system intact, but is broken down to NAM. This quote below is from the most recent review of Therapeutic Potential of NMN and NR.

Substantial fraction of orally administered NR is likely converted into nicotinamide by first-pass metabolism in the liver or by hydrolysis in the blood circulation before its uptake into other tissues (102)

For more info on how NR is converted to NAM in the body.

Not found in bloodstream

In both mice and humans, studies repeatedly failed to find any NR in the bloodstream at any time, even after very high dosages of NR (97, 98, 99).

The following quote from this Dr Brenner study also did not find NR in bloodstream after oral supplements, but was found in trace amounts after Injection

NR varied and displayed no response to NR administration… but was detected after IP of double labeled NR

A small fraction makes it intact to muscle
and other tissues outside Liver

A small fraction makes it intact to muscle and other tissues outside Liver The charts at left are from this 2016 study which used mice that have had the gene for Nampt ‘knocked out’ in quadricep muscle, so are unable to process NAM. As a result, the NAD+ levels drop to 15% of normal.

These mice were fed double labelled NR to track the movement of the NR through the body.

Any NR that makes it through digestion intact would be incorporated as double labelled NAD (M+2). NR that has been metabolized to NAM loses 1 heavy tracking molecule and would be found as M+1.

Chart D shows both single and double labelled NAD+ (green and red) are abundant in roughly equal amounts in the liver.

Chart C shows quite a lot of single labelled NAD+ in the muscle which is from NR that has been metabolized to NAM and then NMN.

We know this NAD+ was metabolized as NAM and then NMN because these mice lacked Nampt in muscle, so can not process NAM.

At the same time, there is only a tiny fraction of double labelled NAD+ in the muscle.

This demonstrates that NMN, but not NR was readily available for use in the Salvage Pathway inside the muscle.

Very Fast to Liver and muscle tissue

After oral NMN supplementation, levels of NMN in the bloodstream are quickly elevated and remain high longer than NAM, NA, or NR (18, 22, 97, 98, 99)

The chart at left shows levels of a double labeled NAD+ (C13-d-nad+) in liver and soleus muscle at 10 and 30 minutes after oral administration of double labeled NMN.

This clearly shows that NMN makes it way through the liver intact, through the bloodstream, into muscle, and is metabolized to NAD+ in 30 minutes (22).

Orally administered NMN is quickly absorbed, efficiently transported into blood circulation, and immediately converted to NAD+in major metabolic tissues (22).

Elevates NAD+ quickly throughout the body

In this 2016 study, mice were given a single dose of NMN in water.

NMN levels in blood showed it is quickly absorbed from the gut into blood circulation within 2’“3 min and then cleared from blood circulation into tissues within 15 min

Increases NAD+ and Sirt1 Dramatically in organs

The charts at left from 2017 study, NMN supplementation for 4 days significantly elevated NAD+ and SIRT1, which protected the mice from Kidney damage.

NAD+ and SIRT1 levels were HIGHER in OLD Mice than in YOUNG Mice that did not receive NMN.

NMN Bioavailability Summary

  • Make their way intact thru the digestive system (22)
  • Quickly elevates levels of NMN in the bloodstream for use throughout the body (22)
  • Quickly elevates levels of NMN in tissues throughout the body (22)
  • Quickly raises levels of NAD+ in blood, liver and tissues through the body (22, 23)
  • Remain elevated longer than NAM, NA, or NR (18)

NAD+ levels decrease throughout the body as we age, contributing to disease and aging. Restoring NAD+ levels can ameliorate many age released health issues.

A large percentage of NR is first digested to NAM, so it cannot bypass the Nampt bottleneck in many tissues. NR is effective at elevating NAD+ in the Liver, but is not stable in the body and not normally found in the bloodstream, which limits it’s effectiveness.

NMN is the only precursor that is stable and available to cells through the bloodstream, and can bypass the Nampt bottleneck to quickly restore NAD+ throughout the body.

REFERENCES:

  1. Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo (Formentini, 2009)
  2. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity (Cato, 2009)
  3. A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis (Imai, 2010)
  4. NAD blocks high glucose induced mesangial hypertrophy via activation of the sirtuins-AMPK-mTOR pathway (Zhuo, 2011)
  5. Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice (Yoshino, 2011)
  6. The NAD (+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity(Canto, 2012 )
  7. NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. (Zhang, 2016)
  8. Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging (Gomes, Sinclair,2013)
  9. Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and repercussion (Yamamoto, 2014)
  10. NAD+ and sirtuins in aging and disease (Imai, 2014)
  11. Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3 (Khan, 2014)
  12. Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer’s disease-relevant murine model (Long, 2015)
  13. NAD+ metabolism and the control of energy homeostasis – a balancing act between mitochondria and the nucleus (Canto, 2015)
  14. NAD+ metabolism: Bioenergetics, signaling and manipulation for therapy (Yang, 2016)
  15. NAD+ replenishment improves lifespan and healthspan in ataxia telangiectasia models via mitophagy and DNA repair( Fang, 2016 )
  16. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans(Trammell, 2016a )
  17. Nicotinamide riboside opposes type 2 diabetes and neuropathy in mice(Trammell, 2016b )
  18. β-Nicotinamide Mononucleotide, an Anti-Aging Candidate Compound, Is Retained in the Body for Longer than Nicotinamide in Rats (Kawamura, 2016)
  19. The first human clinical study for NMN has started in Japan (Tsubota, 2016)
  20. Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death (Wang, 2016)
  21. Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice (Uddin, 2016)
  22. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice (Mills, 2016)
  23. Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice (de Picciotto, 2016)
  24. Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease (Yao, 2017)
  25. Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich’s ataxia cardiomyopathy model (Martin, 2017)
  26. Nicotinamide Mononucleotide, an NAD+ Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1-Dependent Manner (Guan, 2017)
  27. Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway (Wei, 2017)
  28. Short-term administration of Nicotinamide Mononucleotide preserves cardiac mitochondrial homeostasis and prevents heart failure (Zhang, 2017)
  29. Modulating NAD+ metabolism, from bench to bedside (Auwerx, 2017)
  30. Aspects of Tryptophan and Nicotinamide Adenine Dinucleotide in Immunity: A New Twist in an Old Tale. (Rodriguez, 2017)
  31. Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice (Williams, 2017)
  32. NAMPT-mediated NAD biosynthesis as the internal timing mechanism: In NAD+ World, time is running in its own way (Poljsak, 2017)
  33. Effect of “Nicotinamide Mononucleotide” (NMN) on Cardiometabolic Function (NMN)
  34. The dynamic regulation of NAD metabolism in mitochondria (Stein, 2012)
  35. Novel NAD+ metabolomic technologies and their applications to Nicotinamide Riboside interventions (Trammel, 2016)
  36. Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans (Meydayni, 2016)
  37. A high-fat, ketogenic diet induces a unique metabolic state in mice. (Kennedy, 2007)
  38. Ketone body metabolism and cardiovascular disease.(Cotter, 2013)
  39. Ketone bodies as signaling metabolites(Newman, 2014)
  40. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease(Youm, 2015)
  41. The effect of the Spanish Ketogenic Mediterranean Diet on nonalcoholic fatty liver disease: a pilot study.(Guisado, 2011)
  42. β-Hydroxybutyrate: A Signaling Metabolite in starvation response(Morales, 2016)
  43. Physiological roles of ketone bodies as substrates and signals in mammalian tissues(Robinson, 1980)
  44. Ketone bodies mimic the life span extending properties of caloric restriction (Veech, 2017)
  45. Novel ketone diet enhances physical and cognitive performance(Murray, 2016)
  46. Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet.
  47. Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes(Cox, 2013)
  48. Neuroendocrine Factors in the Regulation of Inflammation: Excessive Adiposity and Calorie Restriction (Fontana, 2009)
  49. Beta-adrenergic receptors are critical for weight loss but not for other metabolic adaptations to the consumption of a ketogenic diet in male mice(August, 2017)
  50. A randomized trial of a low-carbohydrate diet for obesity(Foster, 2003)
  51. β-Hydroxybutyrate suppresses inflammasome formation by ameliorating endoplasmic reticulum stress via AMPK activation(Bae, 2016)
  52. The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. (Maalouf, 2009)
  53. AMPK activation protects cells from oxidative stress‐induced senescence via autophagic flux restoration and intracellular NAD + elevation (Han, 2016)
  54. Regulation of AMP-activated protein kinase by natural and synthetic activators (Hardie, 2015)
  55. Effects of Exhaustive Aerobic Exercise on Tryptophan-Kynurenine Metabolism in Trained Athletes (Strasser, 2016)
  56. PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation(Bai, 2011)
  57. Carbohydrate restriction regulates the adaptive response to fasting (Klein, 1992)
  58. Interventions to Slow Aging in Humans: Are We Ready? (longo, 2015)
  59. Extending healthy life span–from yeast to humans (longo, 2010)
  60. Dietary restriction with and without caloric restriction for healthy aging (Lee, 2016)
  61. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan (Longo, 2015)
  62. Diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms (Longo, 2016
  63. Resistance Exercise Training Alters Mitochondrial Function in Human Skeletal Muscle (Porter, 2015)
  64. Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice (Newman, 2017)
  65. The NAD(+)/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling.  (Mouchiroud, 2013)
  66. NAMPT- mediated NAD(+) biosynthesis is essential for vision in mice  (Lin, 2016)
  67. NAD+ replenishment improves lifespan and healthspan in ataxia telangiectasia models via mitophagy and DNA repair( Fang, 2016 )
  68. Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease (Gariani, 2017 )
  69. Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle(Canto, 2010)
  70. The NAD (+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity(Canto, 2012 )
  71. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans(Trammell, 2016a )
  72. Nicotinamide riboside opposes type 2 diabetes and neuropathy in mice(Trammell, 2016b )
  73. Dietary leucine stimulates SIRT1 signaling through activation of AMPK (Hongliang, 2012)
  74. Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3 (Khan, 2014)
  75. NAD blocks high glucose induced mesangial hypertrophy via activation of the sirtuins-AMPK-mTOR pathway (Zhuo, 2011)
  76. The effect of different exercise regimens on mitochondrial biogenesis and performance (Philander, 2014)
  77. Dietary proanthocyanidins boost hepatic NAD+ metabolism and SIRT1 expression and activity in a dose-dependent manner in healthy rats (Aragon’s, 2016)
  78. NAD+ Deficits in Age-Related Diseases and Cancer (Garrido, 2017)
  79. Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation (Ong, 2013)
  80. Chlorogenic Acid Improves Late Diabetes through Adiponectin Receptor Signaling Pathways in db/db Mice (Chang, 2015)
  81. Adenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical Compounds (Marin-Aguilar, 2017)
  82. The Effects of Ramadan Fasting on Body Composition, Blood Pressure, Glucose Metabolism, and Markers of Inflammation in NAFLD Patients: An Observational Trial (Mazidi, 2014)
  83. Comparative effects of carbohydrate versus fat restriction on metabolic profiles, biomarkers of inflammation and oxidative stress in overweight patients with Type 2 diabetic and coronary heart disease: A randomized clinical trial. (Raygan, 2016)
  84. Normal fasting plasma glucose and risk of type 2 diabetes diagnosis (Nichols, 2008)
  85. Are We All Pre-Diabetic? (Stokel,2016)
  86. Hepatic NAD+ deficiency as a therapeutic target for non-alcoholic fatty liver disease in aging (Zhou, 2016)
  87. Effect of exercise intensity on post-exercise oxygen consumption and heart rate recovery (Mann,2014)
  88. A 45-minute vigorous exercise bout increases metabolic rate for 14 hours (Knab,2011)
  89. Effects of high-intensity resistance training on untrained older men. II. Muscle fiber characteristics and nuclei-cytoplasmic relationships (Gerontol, 2000)
  90. Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice (Newman, 2017)
  91. A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice (Roberts, 2017)
  92. NK cells link obesity-induced adipose stress to inflammation (Wensveen, 2015)
  93. The “Big Bang” in obese fat: Events initiating obesity-induced adipose tissue inflammation (Wensveen, 2015)
  94. The impact of the Standard American Diet in rats: Effects on behavior, physiology and recovery from inflammatory injury(Totsch, 2017)
  95. Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP (Shen, 2017)
  96. The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders (Stafstrom, 2012)
  97. Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle (Fredrick 2016)
  98. Digestion and absorption of NAD by the small intestine of the rat (Henderson, 1983)
  99. Effects of a wide range of dietary nicotinamide riboside (NR) concentrations on metabolic flexibility and white adipose tissue (WAT) of mice fed a mildly obesogenic diet(Shi, 2017)
  100. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans (Brenner, 2004)
  101. Nampt Expression Decreases Age-Related Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Sirt1 (Ma, 2017)
  102. NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR (Yoshino, 2017)

 

29 thoughts on “Is Basis by Elysium Health a Hoax?

  1. Chuck says:

    Since I’m not in the clinical studies business, I’ll just have to go with my own experience?

    Extremely positive. I feel it when I’m taking it, and I miss it when I’m not. It’s like batteries: when they’re in, better things happen.

    In addition to all the reported benefits, I’d like to add cognitive function. I’m as sharp, or sharper, then I’ve ever been. And it feels natural an unforced vs. taking a pill. As others have mentioned, I can exercise harder (and recover faster) than before. Helps with weight loss and general health. My mood is elevated and normalized, no more mood swings. Cuts and scrapes heal faster. I almost never get the flu these days (immune system?) and if I do catch cold, it’s a minor short affair at worst.

    I stop taking it for a few days, and all the bad stuff comes back.

    I have three friends that I’ve introduced to it. All have reported positive benefits, all have decided to subscribe.

  2. Lindsay says:

    I will be 55 years old in 3 months. I’m a woman and have been taking Basis for almost six months. I take twice the recommended dosage (4 pills per day), sometimes more. I have noticed the following effects:
    -improved eye sight – I was wearing glasses for about 5 years for reading and felt as though I needed a higher prescription lens. I have not felt I needed or worn glasses for about the past month. My eyes also look clearer and brighter.
    -higher libido – I can’t attribute this to anything else. My libido is stronger than it has ever been in my life.
    -more energy – I wake up from (often crazy, vivid dreams) feeling as though I’ve slept incredibly deeply. Within minutes my energy blossoms into a calm, focused, lovely drive to seize the day. When I need to sleep, I need to sleep though. It’s almost as though my bodily communications have improved to achieve maximum functioning. We detoxify and refresh our brains and bodies in sleep and I feel that recognizing the need for sleep is key.
    -weight loss – I have lost about seven pounds that seems like a reset to the ideal weight (or very close to it) that my body functions optimally at. I’ve gone under a weight that I was constantly hopeful to achieve, without trying.
    -skin – it’s tough to tell, but for the past couple of years, I was feeling as though the quality of my skin was deteriorating rapidly. Lately, it seems a bit brighter, a bit more elastic. Discoloration and sun damage seem to be fading.
    I feel and look better and won’t stop taking Basis.

  3. Tracy Yucikas says:

    I had been curious as to determining weight-loss causation, slow and gradual, over the last 3(?) months or so. I had wanted to believe it was my conscious decision to eat less. However, honesty compels me to maybe attribute the 10 or 15 pounds lost to my usage of Basis, first at 2 pills/day and then 4/day over the past few months.
    The other reported effects are harder to see, but I will probably continue using Basis, even if it *does* seem a bit pricey.
    At age 68, it also made me run the thought-experiment “how long would I have to take Vitamin C to come to the conclusion that it was good for me?” (or would I just sort of accept that Linus Pauling knew what he was talking about?)
    There are many unknowns in life. This “Basis” question may be another one. That being said, I will continue to take it. There is only “one time around” in life.

  4. jim riley says:

    My wife has horrendous thin skin challenges which just with slight scratching turn in to purple bruising — she is 61 and she has tried everything on the planet but so far nothing has worked to thicken the skin — do you think Basis may help this ailment ?

    • Craig says:

      I have been taking 250mg/day of CromoDex nicotinamide riboside chloride for over a year. I am 68 years old. I noticed several years ago that my skin was “thinning” and small wounds caused bleeding that spread under the skin. It looked bad and healed slowly. After about 1 year taking 250mg/day of NR the problem has stopped and the general appearance of my skin has improved. I can’t think of any other diet or medicine change that would account for this improvement.

  5. Anonymous says:

    I have been taking Basis for well over a year. I had rotator cuff surgery last April. When I saw the doctor the next day, he said people rarely look as good as I did after surgery. I healed up within a month, I did PT (the PT was shocked at how I improved so fast) and I can move my arm well over my head. My incisions healed immediately and my pain was almost none after 3-4 days. Hardly took pain pills. All of the busing from surgery went away within a week. I am in good health but at 63, lets face it, not a spring chicken. I read that one of the founders had a serious biking accident and his entire face was cut and bruised. He healed in four days. This is my experience. Haven’t lost weight but I think I am counter balancing that.

  6. Day Brown says:

    The FDA says aging is not a disease, so it wont fund studies. However, post polio is, and the rate of functional decline can be episodic and rapid, ending up totally paralyzed in a respirator (modern iron lung). If the FDA or whoever, would do outreach to post polio, since we are motivated and acutely aware of our condition, our reports on NAD+ or whatever, would be informative.

  7. David says:

    As a soldier exposed to possible sarin gas and possible oil well fires that I saw right in front of me, the entire Army 3rd Armour Division was positioned in the middle of the burning Kuwait oil fields for over two months. 605 burning oil wells in an area of 2,200 square meters and many soldiers have never received any help from the VA because they can not prove a service-connection by way of the Pentagon to verify the soldiers involvement. I am one such soldier that has been sick as a dog with afirmities from every system in my body. Once out of the Army I used my GI Benefits to go to community college and take major biology course prerequisites for nursing like Anatomy and Physiology so I could understand what is happening. Since taking Basis and all the supplements that support each cell individually……cellular respiration increased dramatically. My health improved quickly as I continued to add more of the proper supplements that supports homeostasis. I also take everything from Steven Gundry less the lectin blocker. Specific nutrition from food is just as beneficial as any supplements, pressed dates, ghee, manuka honey, not eating processed sugar of any kind, not eating any meat with antibiotics and the best vitamin Supplement is made in Hawaii from kelp and sea algae….this is not a advertisement HAWAIIAN SPIRULINA !

  8. Humberto Sandoval says:

    41 yo male here…,
    I’ve been taking Basis for about 4 months, personally the product makes wonders,
    I have not experienced any weight loss, or improvement in my skin face or hands,
    One day I took 10 capsules just to experiment, next day I experienced light muscle soreness as though I had worked out,

  9. JS says:

    I don’t understand the numbers on this page. Every time I look at it I see the same number of same doses for $60 whether you go with Basis or with the niagen and pterostilbene supplements suggested here. Where do you get the half the cost claim? I looked around on the web and found similar pricing and then went with Basis because I could get it for only $40 by getting a year’s supply.

    What am I missing?

  10. Jazzman-Boston says:

    Has anyone treated successfully peripheral neuropathy with Basis? Or with supplements with the same ingredients? I did read on a Facebook post that it did “cure” peripheral neuropathy from one person but this of course was anecdotal, still it seems like it could help based on the mitochodrial healing which is claimed (or proven in studies, I need to check). Thanks.

    • Anonymous says:

      Contact me and I can put you in touch with Psychologist friend who has found a way to alleviate a significant number of his symptoms of Familial Periphial Neuropathy.
      michael 954 205 4996

  11. Dan Walsh says:

    It’s very important to remember that the more Basis one orders the lower the cost — it’s not $60 a month but $50 a month if you subscribe to the monthly order rate and as of this writing it can be as low as $40. I’ve been taking it for a number of months now and I’m very happy with the product. If you go to their website you’ll see a wealth of information and can decide for yourself.

  12. Brent says:

    I have been looking for a real supplement for literally years, have tried many, none work. Thinking of trying GenF20 until I stumbled upon this. Can anyone tell me if GenF20 works or should I just go straight for Niagen? I’m using myself as a guinea pig to see it anything works in order to help my father who really needs it. Thank you very much

    • Anonymous says:

      Really funny, but I read the label on Basis. I was already taking Resvervatrol and Pterostilbene. There are several companies that offer both. Same with Niagen. My advice is buy something of the strength you want that comes without fillers. For the Pterostilbene, since it’s from berries, go for non-GMO organic.

  13. Nina says:

    I have not taken Basis, but I have taken Naigen for the last 1.5 years.

    I have no doubts at all as to its effectiveness. From my experience and comparing it to the experience of others, I have come to the conclusion that to see a real, immediate benefit in energy levels, the more impaired one is in producing ATP ADP, the greater and more immediate result one will see. The less impaired, the smaller and less immediate result in changes to ones level of energy, if any, will be seen.

    I come to that conclusion given I have a methylating defect that impairs my ability to produce ADP ATP. I had, for 10 years without knowinig what was causing this, tried to describe how it feels like this: imagine you are a tall office building, with all the lights on, the copiers and other machines humming, the ventilation system running, coffee makers perculating, etc. Now imagine the power went out and the back up generator kicked in. How well can this tall office building run now? Not very well. I had hardy been able to walk or engage in a normal level of activites of daily living for many years. Doctors didn’t seem to understand what I was trying to communicate. Then I discovered my methylating defects. Then I discovered Niagen shortly afterwards.

    I decided to try it.

    People may have a hard time believing this, but within 10-15 minutes of taking my first capsule, I felt like I had been plugged into a nuclear power plant. Energy at levels I had not experienced for years suddenly surged through me. Where I had been mostly confined to a recliner, I was now able to walk freely and go pretty much anywhere I wanted to. 2 months later, I was walking up hills. I found that as long as I continued to take it when I noticed symptoms returning, I was fine and could do much I could not do for the past many years. I found if I didn’t take it, many of my symptoms would return quickly.

    Through trial and error I found I maintain fairly well on 1000 mg a day, needing to take more when demands on my activity levels increase.

    What I did not see was any rejuvenating effects in my skin. At first. For the previous few years I had noticed that my skin was aging fairly fast. I had lost the elasticity in my face. Trying to pinch my cheeks was like trying to pinch a taught fabric covering a chair. Couldn’t be done. The backs of my hands had been taking on the look of an elderly woman’s hands, more translucent, papery, shiny, thin. About 4 months after I started taking Niagen, I was at my daughter’s wedding and I was very sad that nothing had changed in this regards.

    A month later, I happened to rub my cheek absentmindedly, and suddenly realized elasticity had returned to my face – it had become soft and pliable and I was easily able to pinch my cheek. I looked at the back of my hands, and they now looked much, much younger. Gone was the translucent, papery, shiny look. They looked years and years younger. I was amazed and obviously very happy.

    A year later this is still true. I expect that I probably need to take larger doses, given my situation, to experience other benefits reported sooner than later, but right now I am just happy to have a good deal of my life back and am incredibly grateful for the discovery of Niagen and advances being in this area of science.

    They say those with an experience are never at the mercy of those with an argument. I know Niagen works beyond a shadow of a doubt. I’m living it.

    • Anonymous says:

      I read your post because I desperately trying to find some help, I also have the same as u did, and living in pain all the time. I don’t know what brand to buy, I am so happy for you and I hope and pray for the good to continue helping you.

  14. Arthur Reber, Ph.D. says:

    Personal testimony is always interesting but rarely clinically significant. The research to date on humans only hints at effective dosage levels which seem to be somewhere between 300mg and 500mg a day. This shows the drug is safe and effective in raising NAD+ levels in the blood.

    The only evidence for slowing or reversing aging is in other species and at different dosages. The mouse data used dosage levels in excess of what’s recommended here.

    And, importantly, we all need to keep in mind that this is a very complex issue. For starters, we don’t really know what aging is. We also don’t much about how to measure it — counting moments on this earth is just a starting point. There are dozens of different elements involved. We don’t know which, if any, are impacted by NAD+ (with or without) other compounds like resveratrol. We don’t know about various interactions with life-style, diet, exercise, stress levels and a host of other factors. There’s little understanding of individual differences in response to the compounds or to susceptibility to placebo effects.

    And, yes, despite all these known unknowns, I’m taking nicotinamide riboside at the recommended 250mg/day — I regard it as a secular version of Pascal’s wager.

    • Jerry Bruton says:

      Thanks for your comment. I’m 68 years old and I have been on a ketogenic diet for the last two years. Since the mitochondria is a key organelle when in ketosis I thought would give it a try for enhancing the level of NAD.

    • John Flynn says:

      Your comment regarding not knowing what causes aging is poignant. I always think about this when the global warming discussion arises. We really have no idea what causes temperature trends – are we in a trend or normal fluctuations? – and are just trying something to alleviate a fear.

      • Jack says:

        Uh…see also the rest of his comment about Pascal’s Wager. How is it not the safest bet we can make to assume it’s important to sigNIFicantly prioritize taking care of your environment? We really DO have an idea of what causes temperature trends.

  15. Lauten says:

    I have been taking Basis for almost a year. I subscribe yearly so only pay $40 per bottle and take two per day as suggested. I lost weight (about 10 lbs) with zero effort after taking Basis for about 3 months and have kept it off. This was an unexpected development.

  16. Manuel Ariza says:

    What if one combines NIAGEN with other products like PQQ (pirroloquinolin quinone) + UBIQUINOL +PRODUCT B (ISAGENIX) to obtain TELOMERE support, and maybe other molecules that have proven to be effective againts celular malfunctioning like AMBROTOSE from MANNATECH that as you know by supplying GLYCANS to cells drastically improve their interaction according to thier propietary investigation.
    I´m very interested in beginning to try NIAGEN.
    Thanks in advance for your kind reply.
    Manuel

  17. Anonymous says:

    Is there anectodal reporting of weight loss with Basis or other Nicotinamide Rriboside brands? I am experiencing unwanted weight loss while taking Basis but don’t know if that is coincidental. Also, thank you for your report since I did not know of the production of the compounds in Basis.
    RZ

    • admin says:

      Anecdotal reports in the forums here and here, note (roughly in order of occurrence):

      • increased energy
      • smoother/clearer skin
      • improved vision
      • hair regrowth
      • better sleep
      • weight loss
      • improved performance in the gym

      Of course, there is no way to tell if those are due to placebo effect (wishful thinking)

      2 different studies that are already completed and will hopefully publish soon DO monitor weight, which implies the researchers think it’s possible they will see some weight loss.

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