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Sublingual NMN The Best NAD+ booster?

The results achieved by Professor David Andrew Sinclair in his quest for reversing aging have moved from the exceptional to the phenomenal. This brief essay lists the evidence and suggests what may be the best value for money route to implementing an effective lowest-cost protocol for delivering similar or the same results.

This brief Answer/Essay suggests a probable best available delivery method of implementing a protocol for achieving the highest NMN dosage (perhaps well beyond Sinclair’s 500mg/day for 90 days) at the least cost.

 The background to Professor David Andrew Sinclair’s recent results

Some of these are listed at the quite readable 2 April 2017 article of the “Daily Mail online” at Is this pink pill the elixir of youth?

You should note that:

“In the body, NMN is converted into a related chemical called nicotinamide adenine dinucleotide (NAD), which is found in every cell of living organisms and is essential for life. NAD is crucial in fuelling the seven different genes in our body that govern ageing.

However, our NAD levels decline by about 50 per cent as we age, turning off the body’s defences against ageing and age-related diseases such as cancer, diabetes, heart disease and Alzheimer’s.”

And

“Professor Sinclair is so convinced of his pill’s safety that not only has he been taking it himself, so has his 77-year-old father.

The results certainly sound encouraging. Before he started taking a 500mg NMN pill every morning, 47-year-old Professor Sinclair had his blood tested and was told his body had a biological age of 58.

After consuming NMN for three months, he was tested again and his biological age was 32.

As for his father, he’s recently been out-pacing the professor’s younger brother on mountaineering expeditions in their native Australia.

‘He’s as vigorous as he was in his 20s and 30s, and he seems to be getting more energetic,’ says Professor Sinclair.

The manufacturing process of the NMN pill is complicated and expensive, and it currently costs Professor Sinclair more than $1,000 (£797) a month to buy it just for himself.”

I think I may know know how to get the same dose result (of over 500mg of NMN a day) at a much lower cost as outlined below.

“For a start, what his NMN pill cannot do is rejuvenate our exterior appearance — especially if we’re already old.

The fact that Professor Sinclair, a father of three young children, still has no grey hairs and very few wrinkles seems a miracle in itself, but he suggests it isn’t because of his pills.

Hair loss, grey hair and wrinkled skin are not yet reversible, he says, although if you start taking NMN young, it may delay visible ageing, as it’s much easier to prevent hair loss and grey hair than reverse it.”

Key points:

NMN restores the numbers of mitichondria in the nigrostratial “black brain” to youthful levels (ie to age-25 similars) within three months.

Summary of what Sinclair has done with NMN

The results so far are

  • When Sinclair’s mother had her left lung removed, he was told by her doctors that her remaining life expectancy was about a year. Sinclair was not accepting that and he prescribed his mother NMN and she lived for 20 years.
  • Sinclair has taken 500mg of NMN a day for 90 days, with the result his blood-assessed biological age of 58 fell to 32 when his actual age was 47
  • Sinclair’s 77 year old father has taken NMN which has reduced his apparent age by about two or three decades and he has successfully taken up mountaineering
  • Sinclair’s younger brother was so affected by being outpaced by his 77 year old father that he too is now taking NMN.

The Most Effective Delivery System For NMN

Buccal (in the cheeks) and sublingual (under the tongue) delivery is probably the best available method for getting NMN into the bloodstream and onward into the cells of the 200 tissues which need it. See the quoted-below entry about pharmacokinetics on the Wikipedia site about the absorption of Resveratrol, which notes that buccal or sublingual delivery may be up to 250 times more effective than oral delivery for resveratrol.

The molecular weight of NMN is 324 — very low compared to insulin which is about 6,500. Nicotinamide riboside (NIAGEN) for comparison has a molecular weight of 255. Resveratrol has a similar molar mass of 228. NMN also partially dissolves in water. That makes NMN a potentially good candidate for sublingual delivery. See

Sublingual administration — Wikipedia

If you take these tablets sublingually, the absorption could be up to 250 times greater than swallowed tablets.

Many assessments of the solubility and persistence of resveratrol and other AMPK stimulaters or Sirts activators may be mistaken, because these small molecules mainly use the blood as a transport system to get to the brain, muscle and other cells which are their target area of activity. The general measure of the blood content of (say) resveratrol immediately after dosage or after four hours does not necessarily indicate that these molecules have been cleared from the body by the actions of the kidneys or the liver, because these substances may have migrated into their target cells.

Alcohol seems to improve the effectiveness of some sublingual delivery as the Pharmacokinetic extract above implies. Perhaps the best and quickest method of sublingual delivery is to add about a gram of Xylitol under the tongue, which makes the NMN disappear quickly. Xylitol is not only a sugar but also an alcohol — see the Wikipedia entry at Xylitol — Wikipedia

This makes Xylitol perhaps an ideal catalyst for the sublingual delivery of NMN.

Incidentally, one of the best discussions of the bioavailability of NAD can be read at https://www.nature.com/articles/…

That article summarises the current state of knowledge about where Sirtuins 1–7 reside and what they do. Just to provide a brief taste, the overview states

Another excellent article about Mitochondrial Metabolism, Sirtuins, and Agingby Michael N. Sack and Toren Finkel is at

http://cshperspectives.cshlp.org…

The vital importance of NMN in activating all of the seven Sirtuins is a key explanation of the wide-ranging activity of this supplement. The Sirtuins do not simply increase the numbers of mitochondria within the cell, they stimulate the death and destruction of damaged mitochondria and improve intercellular communication, and they almost seem to act as a kind of team of proteins, restoring cellular functions to a much higher level of youthful effectiveness.

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