All supplements in a capsule must first pass thru the stomach and liver
SUBLINGUAL DELIVERY IS THE SOLUTION
This PURE NMN powder can be used sublingually (under the tongue) so it is absorbed directly to the bloodstream and is readily available to cells throughout the body.
PURE NMN is the only NAD+ Precursor available with no fillers, binder, or other ingredients.
THE PROBLEM with CAPSULES – DIGESTED IN STOMACH
More recently, this research published in 2018 confirms that most oral supplements of NMN and NR are digested to NAM in the GI tract or the liver.
Future pharmacological and nutraceutical efforts to boost NAD will need to take into account the minimal oral bioavailability of NR and NMN (R)
We also showed that intravenous, but not oral administration of NR or NMN delivered intact molecules to multiple tissues (R)
Unlike in cell culture where NR and NMN are readily incorporated into NAD, oral administration fails to deliver NR or NMN to tissues (R)
Interestingly, we found that neither compound was able to enter the circulation intact in substantial quantities when delivered orally (R)
The most recent studies showing tremendous health benefits with NMN were accomplished by feeding mice very large dosages of NMN in water (r). However the dosage of 300-400 mg per kg of bodyweight used in many of these studies would equate to approximately 2,000 Mg per day for a 70 kg human. A more effective delivery method is needed !
SUBLINGUAL VS CAPSULES
The absorption of the different molecules delivered through the sublingual route can be 3 to 10 times greater than oral route and is only surpassed by direct IV injection (r).
SUBLINGUAL CAN BE MORE BIOAVAILABLE THAN INJECTION !
With intraperitoneal injection, the primary route of absorption is via the mesenteric vessels, which drain into the portal vein and pass through the liver before reaching the bloodstream.
This means, IP avoids the GI tract, but is still sent directly to the Liver, where much of it is converted to NAD+. Elevated NAD+ in the liver is good, but its far better to reach the bloodstream with intact NMN.
Sublingual delivery is not filtered by the Liver and can reach systemic circulation intact, so can actually result in greater bioavailability that direct injection! Some examples are:
- A sublingual formulation of zol… exhibited a faster rate of absorption and higher drug exposure as compared to subcutaneous injection (r)
- sublingually administered epin… results in more rapid absorption and a higher peak plasma concentration compared to injected epin… .(r)
- 40mg of sublingually administered pir.. was found to be as effective as a 75 mg intramuscular injection of dicl… (r)
NMN PERFECT FOR SUBLINGUAL
Depending on the molecule, Sublingual delivery can substantially improve the speed and bioavailability. Smaller molecules that are hydrophilic such as NMN are well-suited.
a drug which has been formulated for sublingual should ideally have a molecular weight of less than 500 (r)
NAD+ IV clinics have been treating patients for decades.
IV Injections avoid the digestion problem that limits the effectiveness of NAD+ Booster capsules.
They have found that an IV drip which provides a slow, constant supply of NAD+ directly to the bloodstream over a long period of time is the most effective delivery method.
Treatment plans are often 8-14 days, cost $1,000-$1,300 a day, and require the patient to sit for 8 hours or more hooked up to an IV drip.
In the last ten years, NAD+ has been more widely used to help detoxify from other types of chemical dependencies, including benzodiazepines, methadone, suboxone, methamphetamines and stimulants.
Below are some of the most well known clinics:
BR+ NAD Minimizes the Cravings and Withdrawal Symptoms of Addiction Detox through Brain Restoration
Our proprietary BR+ NAD IV treatment restores brain function while minimizing withdrawal symptoms and reducing or eliminating cravings. It further enhances brain function by improving clarity, well-being, and impulse control: your life is your own again.
Improves Brain Function
We are the leading provider of this breakthrough treatment in the US. We provide treatment for a growing list of conditions, beginning with addiction recovery and extending to Parkinson’s, Alzheimer’s & other degenerative diseases.
NAD Treatment Center™ is a provider of Brain Restoration Therapy, using intravenous NAD+. The therapy assists in alleviating brain-destroying diseases of alcoholism, addiction, chronic stress, depression and anxiety. Combining innovation and compassion, our medical team provides healing and hope for people who are affected by substance abuse and addiction. NAD+ supports the detoxification process and brain function to help your ongoing treatment and aftercare
Researchers investigating brain health and longevity have found NAD+ is an essential coenzyme that promotes cellular regeneration. Studies have found replenishing cellular levels of NAD+ can repair DNA, protect brain cells from damage, reduce inflammation and turn on enzymes that help prevent aging.
Intravenous NAD+ has been used since the 1960s to help individuals detoxify from alcohol and opioid dependencies. In the last ten years, NAD+ has been more widely used to help detoxify from other types of chemical dependencies, including benzodiazepines, methadone, suboxone, methamphetamines and stimulants.
Many chronic conditions, including chronic fatigue syndrome, neurodegenerative disease and mental health disorders have been linked to cellular dysfunction and dysregulation. NAD+ therapy may help reduce the symptoms of many chronic conditions, and may help individuals suffering from chronic conditions regain their vitality and strength.
What if there was a compound that could turn back time, restore energy, improve athletic performance, bring back clarity of thought, reverse depression and help cure cravings for alcohol and drugs even in the most addicted individuals?
There is such a substance. It is called NAD+, and it occurs naturally in every cell in your body.
Compelling research has shown that supplementing with NAD+ may help you withdraw from addictive substances safely, overcome anxiety and depression, handle acute and chronic stress more effectively, and cope better with PTSD.
In fact, clinics across the US are starting to use IV infusions of NAD+ to help people withdraw from drug and alcohol addiction with minimal symptoms in as little as 7-14 days of treatment. These individuals report feeling calm and content and say they lost their “cravings” after a full course of treatment.
And NAD+ may actually prolong life, protect DNA, slow down aging and help restore function in neurodegenerative illness due to its effects on the genes that govern aging.
Dr. Starr prescribes Nicotinamide Adenine Dinucleotide (NAD+) for intravenous administration under the supervision of our trained registered nurses. NAD+ treatments are performed in our outpatient infusion rooms. While each infusion session typically takes a full 6-8 hours, the duration of NAD+ treatment typically requires 10 (or more) sessions to ensure complete results. For treatment for a non-addiction disorder, such as stress or anxiety, your treatment course may be shorter, and is ultimately determined during your medical assessment with Dr. Starr.
NAD+ Therapy involves a high dose intravenous infusion of NAD+ that goes straight into the bloodstream. IV therapy allows NAD+ to bypass the digestive system for better absorption. NAD+ works rapidly to repair cells throughout the body and neurons in the brain. When your NAD+ levels are increased, your cells produce more energy, your good genes are “turned on”, DNA is repaired, and many other functions are optimized. Since NAD+ is such a powerful and prolific molecule in the body, high dose IV therapy can be helpful for many different conditions.
CONDITIONS SUCCESSFULLY TREATED WITH NAD OR BRAIN RESTORATION THERAPY BR+
Reflex Sympathetic Dystrophy
Chronic Migraine Headaches
Depression / Anxiety
NAD is short for Nicotinamide Adenine Dinucleotide. NAD is a coenzyme of Niacin, which is vitamin B3. Niacin produces energy in the body which is needed for its proper function and well-being. However, people that are involved in drug and alcohol abuse are deficient in NAD making it hard for them to get over their addictions. It is no wonder high-end drug rehabs used it to detox heavily addicted patients from tranquilizers, alcohol and stimulants among others.
NAD IV Drips Brain Restoration Therapy
A majority of people that are addicted to alcohol and other harmful drugs usually suffer from a severe form of neurotransmitter imbalance. This imbalance results in them experiencing insomnia, depression and anxiety among others. Apart from this imbalance, their bodies also absorb nutrients poorly leading to other mineral imbalances and their capability in forming neurotransmitters is also negatively affected. However, when amino acids are introduced into the body along other vitamins and coenzymes the proper levels are re-established and neurotransmitters begin to be properly circulated in the body, thus eliminating or at least reducing the withdrawal effects a drug addict would have otherwise experienced.
NAD IV Drips Brain Restoration Therapy is based on the supplementing of amino acids in the body so that it can be able to produce its own neurotransmitters and utilize them properly as well. When the production and utilization are done well through exercise and proper nutrition, the drug addict begins to get closer to being completely cured other than the suppression of symptoms as other conventional therapies have been known to do.
In general, the use of NAD amino acid IV drips to repair the brain of drug addicts has been quite successful. For those considering signing up for the treatment in any of the drug rehab centers run by professionals, it is important to note that:
The treatment only works when followed as described by a health worker at an accredited facility. Also, the length of treatment varies from one person to another thus making it important to exercise patient while seeking this kind of treatment for addiction. For example, alcohol addiction can be overcome much faster when compared to other hard drugs. Patients interested in NAD amino acid IV Drips should expect to be discouraged by medical experts on the use of this addiction treatment but with the proper administration, the results are likely to be successful. Finally, NAD IV Drips for Addiction Treatment can be a bit costly but the benefits are worth it in the long run.
How is NAD Therapy Used?
NAD Therapy Requires The Use Of An IV DripIn NAD Therapy, the co-enzyme is placed in an IV and slowly dripped into the blood stream. This allows the substance to bypass the stomach (where analgesic medication breaks down) and travel directly to the brain. This provides the individual with a boost of energy, providing enhanced mood and awareness, as the energy they get is now from their natural sources, not other substances. It has also been claimed to slow the aging process. These benefits have opened the door for clinics to use it as a luxury, like a spa treatment.
Advertising it as an all-natural, mood-elevating, no-crash, anti-aging energy booster, clinics are selling to people who have not suffered an addiction of any kind. It is advertised as a therapeutic treatment to give them more energy and reverse aging. This procedure isn’t as lengthy as someone looking for rehabilitation and can be sold as a regular treatment appointment, receiving a “top off” every 6 to 8 weeks.
Why Use NAD Therapy to Treat Addiction?
It has been determined that the excessive use of drugs and alcohol will deplete the body’s natural stores of NAD. Because of this, the brain cannot receive the same energy it usually would from breaking down food. NAD Therapy floods the brain with the co-enzyme to replenish its stores, providing three key effects.
It flushes out all of the drugs that are still in the user’s system.
It curbs the cravings for alcohol and Opioids and lessens the pain of withdrawal, making recovery easier physically and mentally.
It allows the body to produce energy more naturally, without a crash or jitters like caffeine and sugar or the negative effects that come with other substances.
Length of sessions vary depending on severity of the addiction and what the clinic recommends. After the initial session, follow ups will be scheduled 1 to 2 months later. These sessions can continue at the discretion of the prescribing clinic.
It is imperative there is no doubt the finished product is free from harmful impurities and includes the quantity of NMN specified on the label. The 3 step quality certification process we use entails:
1. ACCEPTANCE TESTING:
Our initial acceptance testing ensures the raw ingredient does not include harmful amounts of heavy metals, alcohol (solvent) or microbials and is > 99% purity.
2. PRODUCT ASSURANCE TESTING:
After bottling, we send a random bottle to a second lab for product assurance testing that verifies the finished product has at least the quantity of Mg per capsule specifed on the label.
3. QUALITY CERTIFICATION:
Lastly, we ship a random sealed bottle to a third laboratory to verify the finished product meets the standards for strength and purity specified on the label.
We use 3 DIFFERENT LABS to certify the strength and quality of every batch of our NMN products.
SHORT WINDOW FOR MAXIMUM AVAILABILITY
The chart at right is from the 2016 Mills study with mice given 300 mg/kg of bodyweight by oral gavage.
It clearly shows NMN is found in blood plasma within minutes, peaking at around 15 minutes. After that, NMN drops rapidly in blood, and appears as increased NAD+ in the liver.
Of course this is in Mice, and humans have a slower response, but we believe it is during the short time period when NMN is available in the bloodstream and can reach tissues throughout the body that the real benefits occur.
FREQUENCY – HOW OFTEN TO TAKE
Nearly all research on mice and humans using NR and NMN is focused on measuring NAD+ and the various metabolites in the Liver as it is the primary supplier of NAD+ throughout the body (r).
If elevating NAD+ in the liver is the goal, 1-2 larger dosages per day seem to be sufficient to achieve the maximum increase in liver NAD+ (r).
OUTSIDE THE LIVER
However, we believe supplying NMN directly to the bloodstream is more effective at increasing NAD+ not just in the Liver, but throughout the body.
Smaller, More Frequent dosages
Based on the short window that exogenous NMN is available in the bloodstream before being filtered out by the Liver, we believe smaller, more frequent dosages are likely more effective than 1-2 larger dosages.
Using this philosophy, many of our customers have been reporting more perceived benefit from more frequent intake, with many taking 6-12 times per day. We recommend taking 4-8 times per day, with at least 1 hour between dosages.
NOT EVERY DAY
We recommend taking 2-3 days off per week, ideally on days when you will be getting the least exercise. If you relax more on the weekend that is a good time to not take NMN.
CONCLUSION – WHAT WE RECOMMEND
Dr Sinclair takes 500 Mg of NMN CAPSULES per day and prescribes the same for his father, which is in line with dosages used in current and recently completed research on humans.
There is likely an upper limit on the effective dosage of NMN and NR capsules, which seems to be between 500 and 1,000 Mg per day.
We believe that sublingual delivery allows a much greater percentage of NMN to bypass the liver and reach other tissues.
When split between multiple smaller dosages, we believe 1,000-1,500 Mg a day can be taken before reaching the limit on maximum effectiveness.
We recommend taking 1 tablet, 4 to 8 times per day. Ideally, 1 upon waking, 1 immediately before and after exercise, and 1 before bed, with any others spread throughout the day.
This product is not intended to diagnose, treat, cure, or prevent any disease.