Younger, Beautiful Skin with Life Extension Phytoceramides (with Lipowheat)

beautiful-skinLife Extension Phytoceramides with Lipowheat is being called the new Botox alternative. Phytoceramides, recently approved by the FDA as a dietary supplement, is shocking dermatologists all around the world and for good reason. The studies on this supplement done at Osaka City University, which requires no prescription, have shown how easily you can turn back time in regards to aging skin.

The beauty and anti-aging industry is huge and is bound to take a blow. Over $1 billion dollars is spent each year on Botox alone thanks to the nearly 3 million people who use it regularly. Botox comes with a hefty price tag and possible health risks. So the introduction of a natural supplement that’s FDA approved, much cheaper than Botox or plastic surgery and can provide the same results is certainly going to make waves in the industry.
Ellen DeGeneres, Cindy Crawford and Jennifer Aniston are just a few of the celebrities who have admitted to using Phytoceramides to get the beautiful smooth skin they require. You don’t have to be a superstar to reap the benefits of this supplement, though. So forget paying thousands of dollars for plastic surgery or Botox injections!

“What Phytoceramides does is get rid of all the old, dead layers of skin and help your skin generate fresh new ones. They move up from the younger skin, to the older skin from the inside out. They bind the skin together and make your skin more plump. The water doesn’t escape as much, youg et less cracking, and the wrinkles go away! Even the dryness is less obvious!
– Dr. Oz

The clinical Studies on Phytoceramides

The 6-week study at Osaka City University consisted of 33 men and women with dry, rough skin. They used Phytoceramides in the form of soft gel capsules. The powerful combination of ingredients appeared to almost start taking action immediately. It appears that, when you take this supplement daily, your skin’s ability to moisturize itself. It also increases the production of collagen and decreases the production of elsastase. This naturally leads to younger looking skin.

But that’s not all. It can also help protect your skin from harsh elements like pollution and the sun, as well as decrease the effects of stress on your skin. No side effects were noted during the study.

What are Phytoceramides?

Ceramides are a natural substance found in your skin. But over time, the amount of ceramides dwindle away. This leads to dryer skin and you start noticing that skin sort of sags. Phytoceramides are an extremely powerful antioxidant found in rare plants. They replenish your ceramides, recreate a protective skin layer that’s been lost and helps your skin to hydrate itself from the inside out.

Dr. Leif Rogers and Dr. Shirley Madhere, both highly acclaimed plastic surgeons, vouch for Phytoceramiedes’ ability to reduce wrinkles and fine lines. They hydrate and plump your skin so you naturally have smoother, tighter skin.

Life Extension with Lipowheat2Other powerful ingredients and benefits you get from Phytoceramides:
Peptides – Increases skin elasticity and boosts collagen production
Ceramosides – Protects your skin pollution, the sun and UV rays and stress
Antioxidants – Reduces and protects from free radical damage

Taking oral supplements of it releases Phytoceramides directly into your bloodstream. This means that it affects all of your skin, not just the skin on your face like other products. This is a game changer. Dr. Oz recently coined this supplement as “the secret to cheat your age”, “Drop a decade from your face” and “Faking a facelift”.

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So in a nutshell, here’s what you can expect when you take Life Extension Phytoceramides with Lipowheat:

  • Get rid of wrinkles and fine lines
  • Disappearing age and sun spots
  • Disappearing under-eye bags
  • Firmer, smoother skin overall

The most recent research proving the effectiveness of Phytoceramides is published here, and partially shown below:

Results Thirty-one subjects completed the twelve-week study; no adverse events were recorded during the study. Statistically significant improvements from baseline mean hydration score were observed in active groups at weeks 2, 6, and 8. A statistically significant difference was observed between mean differences from baseline scores for total wrinkle count at week 4 for the combination active groups compared to placebo. A statistically significant difference from baseline scores for fine lines count was also observed at the week 4 visit compared to placebo for both active groups. Statistically significant differences from baseline scores for average wrinkles severity were seen for week 12 visit for both active groups compared to placebo.

Background
Aging is an unavoidable, biological phenomenon affecting all multicellular organisms.1A growing number of studies confirm an important effect of diet, lifestyle, and physical activity on health status, the aging process, and many metabolic disorders. Many dermatologic conditions are chronic with no definitive cure. For some conditions, the etiology is not completely understood, with limited effective options for treatment. Dietary modification, through supplementation and elimination diets, has become an area of interest to help prevent onset, reduce symptom severity or prevent reoccurrence of the condition.2

Various hypotheses have been put forward to explain the molecular reasons for aging, a prominent role among them being played by the free radical theory of aging.3,4 Free radical components (reactive oxygen species or ROS) or lipid peroxide (LPO) is involved in the pathogenesis and progression of accelerated skin aging and chronic skin conditions such as acne vulgaris. Under normal physiological conditions, ROS production is tightly regulated, and ROS participate in both pathogen defense and cellular signaling.
However, insufficient ROS detoxification or ROS overproduction generates oxidative stress, resulting in cellular damage. Either underor overactive ROS has been linked to various inflammatory skin conditions. The cellular redox balance must be tightly regulated by several (enzymatic) antioxidants and dietary antioxidants; however, in case of chronic inflammation, the antioxidant system may be depleted and prolonged oxidative stress occurs. Due to the central role of ROS in inflammatory pathologies, restoring the redox balance forms an innovative therapeutic target in the development of new strategies for managing inflammatory skin conditions. The use of antioxidant-related therapies such as nutraceuticals is of particular interest in restoring skin homeostasis and health.5,6

Numerous studies have been conducted on the effects of supplementation with antioxidant vitamins,
other natural and synthetic antioxidants, and antioxidant-containing preparations on the aging process. Results of these studies provide inconsistent data on the anti-aging or even the life-prolonging effects of supplementation with oral antioxidant therapy.7,8

Zeaxanthin is one of the most common carotenoid alcohols found in nature. Animals derive zeaxanthin from a plant diet.9 Zeaxanthin is one of the two primary xanthophyll carotenoids contained within the retina of the eye. Within the central macula, zeaxanthin is the dominant component, whereas in the peripheral retina, lutein predominates.10

Zeaxanthin supplements are typically taken on the supposition of supporting eye health. In the macula of the eye, lutein and zeaxanthin function as filters of the damaging blue wavelengths of light and act as antioxidants to prevent free radical damage. These carotenoids are also found in significant quantities in human skin. Following oral administration, lutein and zeaxanthin may help decrease the formation of ROS associated with UV light exposure. One study confirmed that lutein and zeaxanthin may improve cell viability, reduce elastin deposition, and inhibit Matrix metalloproteinases (MMPs). The latter finding suggests a mechanism by which these carotenoids may maintain healthy skin.11

The inconsistent data in the literature on oral antioxidant therapy alone have raised the question of if the combination of oral antioxidant therapy plus topical skin therapy would provide more consistent outcomes in the anti-aging realm.

With zeaxanthin, an oral and topical test product(s) have been developed to improve the appearance and condition of skin when used as directed. This clinical trial was developed to begin to collect data on the utility of these products in subjects with signs of photodamaged skin.
Methods

Conclusion
We have shown that the combination of zeaxanthin-based dietary supplement plus a topical formulation produces superior hydration to that of placebo. Additionally, we have shown that the combination of oral and topical combination vs. oral alone has superior abilities to improve parameters associated with facial lines and wrinkles compared to placebo, although the dietary supplement alone proved most effective in reducing wrinkle count and severity.

Multispectral lighting (diffuse white light, crosspolarized, blue and parallel polarized) reveals skin conditions on the skin’s surface layer. The system uses skin feature recognition to apply automated skin segmentation and zone mapping to allow for subsequent skin analysis (proprietary algorithms).
This study was reviewed and approved by the institutional review board (IRB, Allendale IRB, CT).
Key inclusion criteria were as follows: females, in good general health, and between the ages of thirtyfive to sixty-five years, inclusive, at time of enrollment, Caucasian or Hispanic origin and baseline Crows’ feet lines and wrinkles grade of ≥2 centimeters (cm) on a ten cm Visual Analogue Scale (VAS) at baseline.

Key exclusion criteria were as follows: pregnant, breastfeeding, or planning a pregnancy at time of study enrollment, participating in any other clinical studies, known allergies to any ingredients in study products, subjects who routinely engage in sun exposure either recreationally or through daily employment and/or other activities and recent (within 30 days) use of nutritional supplementation.
Statistical analysis was performed using SPSS software (IBM). Difference between each time point and baseline values for each group compared between groups utilizing an unpaired t-test. Significance was set atp<0.05. Results
Demographic data are presented in Table 2. Thirtyfour subjects were enrolled into this study, three subjects were discontinued for noncompliance of study product (<80%) and thirty-one subjects completed the twelve-week study, no adverse events were recorded during the study. Hydration
Statistically significant improvements from baseline mean hydration score were observed in the ZO-2 at weeks 2, 6, and 8. When data from the different product groups were compared, statistically significant differences were observed between the mean difference from baseline scores for hydration for ZO-2 + ZT vs. PL at week 2 and week 4. In all instances, results from ZO-2 showed a significantly greater mean improvement than those from other groups. No further statistically significant differences between group results were observed.

Oral Placebo
Subjects were divided into three groups: two tests (ZO1 and ZO-2 + ZT) and one placebo control (PL). The study consisted of a washout visit, baseline (randomization), week two (2), week four (4), week six (6), week eight (8), and week twelve (12). Instrumental assessments, MoistureMeter SC (Delfin Technologies, Finland), and ClarityTM 2D Research System Ti (BrighTex Bio-Photonics (BTBP), San Jose CA, USA) image analysis were measured at baseline and each subsequent visit (image analysis not performed at week 6 per protocol). Key parameters measured were as follows: fine lines, deep lines, total wrinkles, wrinkle severity, radiance/skin color (L, a*, b*), discolorations, and skin pigment homogeneity.

The MoistureMeter SC is a laboratory grade instrument that measures skin hydration sensitively and accurately. The MoistureMeter SC measures the capacitance of the layered structure composed of the probe, stratum corneum, and the underlying skin layers. The measured capacitance is directly proportional to the water content of stratum corneum. The measurement frequency is 1.25 MHz. The effective measurement depth of the MoistureMeter SC depends on the thickness of the dry layer and is thus dependent on the individual subject’s skin condition.
The ClarityTM 2D Research System Ti (BrighTex BioPhotonics (BTBP), San Jose CA, USA) captures highquality full face frontal, left, and right lateral images. Three cameras within the system allow for 18 megapixel SLR image capture in 16-bit simultaneously using Clarity image analysis Lines/Wrinkles have been shown to have significant effects on melanoma–fibroblasts interaction suggesting antitumor activity.13

Furthermore, lutein and zeaxanthin have been shown to protect keratinocytes against UV light irradiation.14 Palombo et al.11 showed that both zeaxanthin and lutein administered as a topical, oral or administered as both bolstered antioxidant activity in the skin as measured by lipid peroxidation, and the combination of oral and topical was shown to be superior to either alone in its photoprotective activity against UV irradiation.
In this clinical evaluation, we have shown that the combination of zeaxanthin-based oral formulation plus topical formulation produces superior hydration to that of placebo. Palombo also showed the combination of oral and topical zeaxanthin to have superior hydration properties to zeaxanthin alone although both provided improved hydration compared to placebo.11 Guillou et al.15 reported a significant increase in skin hydration in women who were supplemented with phytoceramide capsules for 3 months.

Yang et al. showed oral supplementation with sea buckthorn (Hippophae rhamnoides) for 12 weeks improved skin hydration and reduced skin roughness in subjects with dry skin.16 By promoting healthy epidermal bilayer, Yang et al. revealed sea buckthorn (Hippophae rhamnoides) may offer a beneficial effect and treatment option for atopic skin conditions.17

Within these clinical results, it is proposed the combination of zeaxanthin, phytoceramides, and sea buckthorn (Hippophae rhamnoides) oils is the contributing factors for the superior hydration results found in groups ZO-1 and ZO-2 + ZT over Placebo (Table 3).11,15–17

When data from the different product groups were compared, a statistically significant difference was observed between mean differences from baseline scores for total wrinkle count at week 4, ZO-1 showed statistically greater mean improvement over ZO-2 + ZT.
A statistically significant difference from baseline scores for fine lines count was also observed for ZO-1 vs. PL and ZO-2 + ZTvs.PLattheweek4visit.ZO-1andZO-2 + ZT showed a significantly greater mean improvement than that of PL for the remainder of the study.
Statistically significant differences from baseline scores for average wrinkles severity were seen for ZO-1 vs. PL at the week 12 visit. Results from ZO-1 showed a significantly greater mean improvement than those from other groups.

Statistically significant differences from baseline scores for emerging lines were observed for group ZO-1 vs. ZO-2 and for ZO-1 vs. PL at the week 12 visit.
Clarity image analysis – Spots/Skin Color
No differences were observed between any parameters from baseline in terms of skin color, spots, and skin homogeneity. Table 3–7.

Discussion
In addition to their role in eye disease that has been well documented,12 zeaxanthin and its isomer, lutein, Additionally, we have shown that the oral and topical combination (ZO-2 + ZT) and dietary supplement alone (ZO-1) have superior abilities to improve parameters associated with facial lines and wrinkles compared to placebo (Tables 4, 5, 6, 7). Superior hydration has been shown to improve the appearance of facial lines and wrinkles.18,19

Therefore,combined dietary supplement and topical serum (ZO2 + ZT) had significant improvements in both fine lines and emerging lines supported by hydrating effect and the skin being plumped with the topical serum resulting in smoother less textured (rough) skin.19 However, the dietary supplement alone (ZO-1) improved wrinkle count and severity, a composite measure of deep lines, wrinkle length, and wrinkle width; this may be due to it is not surprising that the the protective effects of the dietary supplement compound, as the actual numbers improved slightly and the difference became apparent in the worsening of the placebo group.

These results for the dietary supplement group (ZO-1) is intriguing as it may reflect the positive effect of nutraceutical-based antioxidants, omega fatty acids, phytoceramides, and botanical extracts on skin shown by several authors.3,4,8,13–17
Although this study was somewhat underpowered to show differences between the combination of oral supplementation with topical treatments and oral supplementation alone, several parameters were shown to be superior to placebo. Future studies should emphasize proper power analysis to differentiate oral use alone from combination therapy, although the antioxidant hypothesis is further supported by these data.