NAD+ levels fall as we age.
Restoring NAD+ may restore youthful health and vitality
NAD+ levels fall as we age.
MORE NAD+ MEANS MORE LIFE
NAD+ is the basic currency that all cells in your body use to function.
Chronic inflammation consumes increasing amounts of NAD+ as we age. Restoring NAD+ helps your cells perform more like they did when young
Why Sublingual - the problem with capsules
Recent research shows NAD+ and precursors such as NR and NMN are almost completed digested in the GI tract and LiverRead now
NMN, NR, or NAD+ ?
Researchers are intently focused on how to increase NAD+ levels in tissues throughout the body, so what's the case for taking NMN or NR instead of NAD+ supplements?Read now
What is NAD+ and how to restore it ?
NAD+ supplements and precursors help replenish depleted NAD+ levels.Understanding how exercise and nutritioninfluence NAD+ helps you make the right choices more often.Read now
Slc12a8 does not solve the bioavailability problem for NMN Capsules Research published in January 2019 that found an enzyme named Slc12a8 that can transport a small quantity of Nicotinamide Mononucleotide (NMN) directly into some cells.
However, this enzyme is only prevalent in the small intestine of older, sicker animals and humans.
The Slc12a8 enzyme was just discovered because it plays a very minor role, and does not transport a large enough quantity of NMN to have been noticed earlier. - more about Slc12a8.
Yes, Increasing NAD+ in the blood IS a good thingDr Masterjohn says he believes supplying the liver with NAD+ precursors and letting it “drip feed” NAM into the bloodstream is the safer, more natural method to help restore NAD levels and that supplying NAD+ directly to the bloodstream may be unsafe. Dr Brenner’s latest research with nursing mice were he asserts that the sole mechanism for the greatly improved health of babies whose mothers received NR was the increased NAD+ in blood of the mothers.
Dr Brenner on Nataile Marie PodcastDr Brenner says he doesn't recommend NAD+ clinics as he thinks anything with needles is unnecessary, while NR is proven safe and is more convenient. We were happy to hear Dr Brenner say that it is increased NAD+ in the bloodstream clearly has the great benefit, as that provides further justification for using a sublingual NAD+ tablet or powder to bypass the digestive system and deliver NAD+ direct to the bloodstream in a very convenient manner.
Dr Chris Masterjohnon Peter Attia Podcast
I like the way Chris explains things – much more understandable than most PHD’s. It helped me understand better about methylation, where clearly he is an expert and he believes is a potential roadblock to getting the most from a NAD+ booster. Peter says he thinks sublingual NMN is likely most effective. Chris doesn’t disagree, but says “if you didn’t have that choice “(sublingual or IV) then …Chris doesn’t seem aware of the research on slc12a8 transporter- maybe this was recorded months ago?
David Sinclair on Joe Rogan Podcast
Joe Rogan interviewed Dr Sinclair for 2 1/2 hours last week, and aired on his popular podcast on Jan 29th. We were looking forward to this for weeks, as Dr Sinclair is always a great interview and probably the most knowledgable person on the planet regarding the current state of research on NAD+. In case you’re not that familiar, research with NAD+, and compounds to boost it like NMN and NR, are showing incredible results for health and longevity.
This research published Jan 7 2019 solves a mystery that has been the focus of intense speculation by scientists in this field for several years – how NMN enters the cell in order to become NAD+ and that it does not need to convert into NR (Nicotinamide Riboside) to do so.
Scientists at Washington University School of Medicine in St. Louis led by Shin-ichiro Imai, MD, PhD, have found the protein Slc12a8 rapidly transports NMN directly into cells.
NAD+ increases metabolism, decreases hunger and blood glucose
This study published Sept 26 2018 gave obese mice 1 mg/kg of NAD+ by inter peritoneal injection for 4 weeks, which restored NAD+ levels in the hypothalamus to normal levels.
The hypothalamus is the master regulator of metabolism. Decreased levels of NAD+ are found in hypothalamus with obesity, disease, and the normal aging process.
Is NMN more effective than NR
Mice that received NMN had nearly 100% increased endurance vs the control mice, and actually grew NEW blood vessels. This was after 60 days, in 20 month old mice (equivalent to 90 year old humans).
Along with the impressive increased endurance, the study shows NAD+ increase is over 500% at 60 days
The Life Extension pathways with NAD+
NAD+ levels markedly decline with age, creating an energy deficit that decreases the body’s ability to retain youthful function.To give you an idea how impactful NAD+ can be, by age 50 a typical person may have only half the NAD+ they did in youth. By age 80, NAD+ levels drop to only 1% to 10% expressed in youth. Deficiency of NAD+ predisposes us to accelerated aging and impedes our ability to fully benefit from resveratrol.
This study fed lactating mice Nicotinamide Riboside (NR) in chow for 21 days after birth of offspring to measure the effect on the health of their pups who did not receive any NR. After 21 days, the pups were removed from the mothers and fed normal chow. Surprisingly, the offspring whose mothers received NR exhibited: