NMN Featured Products

NMN's - 30 ct
Sublingual Tablets

New Citrus Burst - flavor
Fast dissolve.  Non-GMO
Gluten-free.  Vegan friendly.
30 tablets / 125 mg each
$24.95

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PURE NMN
Sublingual Powder

100% Natural, Non-GMO
Gluten-free.  Vegan friendly
12 grams pure powder
125 mg per scoop
$69.95

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NMN's - 240 ct
Sublingual Tablets

New Citrus Burst - flavor
Fast dissolve.  Non-GMO
Gluten-free.  Vegan friendly.
240 tablets / 125 mg each
$149.95

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NMN's - in Tins
Sublingual Tablets

New Citrus Burst - flavor
Fast dissolve.  Non-GMO
Gluten-free.  Vegan friendly.
60 tablets / 125 mg each
$49.95

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About NMN
NMN has shown the most dramatic effects in long and short term experiments in mice.  Research studies  with humans have been successfully completed showing safety and increased NAD+ levels, with Phase 2 testing for treatment of specific disease conditions planned to start in mid 2019.

BIOAVAILABILITY ISSUE
It has long been known that when swallowed, NAD+, NMN and NR are mostly hydrolyzed to NAM in the stomach.
This study showed supplementation with NAM increases NAD+ levels just as much as NR and NMN, and it is not known how much more effective an oral supplement of NR, NMN or NAD+ is as compared to regular old NAM.
More surprising, was the Liu study published in Mar 2018 that clearly proved nearly all supplements of NR and NMN are digested to NAM in the stomach or liver, with very little reaching past the liver.
So while researchers have had success using oral supplementation with NAD+ precursors such as NR and NMN to increase NAD+ levels inside the body, they are all clearly degraded when passing through the stomach. 
SUBLINGUAL DELIVERY
Taken sublingually (under the tongue) NAD+, NMN and NR may be more effective as they can be rapidly absorbed directly to the bloodstream, bypassing the GI tract entirely.

NAD+ Supplements

PURE NAD+TM – in Tins

Sublingual Tablets

New Citrus Burst tm flavor

Fast dissolve.  Non-GMO

Gluten-free.  Vegan friendly.

60 tablets / 125 mg each

$44.95

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T

PURE NAD+TM 

Sublingual Powder

100% Natural. Non-GMO

Gluten-free.  Vegan friendly.

12 Grams pure powder

125 mg per scoop

$69.95

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LIQUID NAD+TM 

Sublingual Drops

Citrus Burst tm flavor

Non-GMO. Gluten-free.

Vegan friendly.

30 doses / 125 mg each

$34.95

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       LIQUID NAD+             NASAL SPRAYtm 

Citrus Burst tm flavor

Non-GMO. Gluten free.

Vegan friendly

120 Doses / 25 mg per mist

$35.95

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NAD+ has been shown to  directly increase metabolism and combat a wide range of disease  with IV and IP injections in mice. In humans, NAD+ clinics use slow drip injections to treat drug and alcohol addictions, depression, and neurological conditions.

BIOAVAILABILITY ISSUE

It has long been known that when swallowed, NAD+, NMN and NR are mostly hydrolyzed to NAM in the stomach.

This study showed supplementation with NAM increases NAD+ levels just as much as NR and NMN, and it is not known how much more effective an oral supplement of NR, NMN or NAD+ is as compared to regular old NAM.

More surprising, was the Liu study published in Mar 2018 that clearly proved nearly all supplements of NR and NMN are digested to NAM in the stomach or liver, with very little reaching past the liver.

So while researchers have had success using oral supplementation with NAD+ precursors such as NR and NMN to increase NAD+ levels inside the body, they are all clearly degraded when passing through the stomach. 

SUBLINGUAL DELIVERY
Taken sublingually (under the tongue) NAD+, NMN and NR may be more effective as they can be rapidly absorbed directly to the bloodstream, bypassing the GI tract entirely.

NAD+ Optimizer Products

NAD+ / AMPK ACTIVATORTM 

Activates intracellular NAD+ production 

Fisetin, EGCG, Pterostilbene

Astragaloside IV, Ellagic Acid

60 capsules / 700 mg serving

$27.95

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NAD+  DEFENDERTM 

Anti-inflammatory  protects intracellular NAD+ 

MSM, Curcumin, Boswellia

Berberine, Silibinin, Piperine

120 caps / 700 mg serving

$32..95

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NAD+  ENERGIZERTM 

Nitric Acid, H2s Amplifier 

Taurine, NAC, Allicin

Astaxanthin, Methyl Folate

60 caps / 700 mg serving

$24..95

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NAD+  OPTIMIZER SERIESTM 

Protect, Restore, and Energize NAD+ levels as part of our Total NAD+ Restoration Therapy

3 Bottle Package

$69.95

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Note:  The 4 products above do not contain NAD+ or NMN

They are designed to maximize NAD+ levels by stimulating internal AMPK production (NAD+/AMPD ACTIVATOR), minimize excessive NAD+ consumption from chronic inflammation (NAD+ DEFENDER), or increase H2S and Nitric Oxide levels in the bloodstream to increase angiogenesis (NAD+ ENERGIZER)

They can be taken by themselves, or in combination with NAD+ or NMN supplements for a Total NAD+ Rejuvenation Therapy that is more effective than NAD+ precursors alone.

Low NAD+ Leads to Disease and Aging

WHAT IS NAD+

NAD+ is a key co-enzyme that the mitochondria in every cell of our bodies depend on to fuel all basic functions. (3,4)NAD+ play a key role in communicating between our cells nucleus and the Mitochondria that power all activity in our cells (5,6,7)Scientists have now confirmed a direct link between falling NAD+ levels and aging in both animal and in human subjects.

NAD+ DECLINES WITH AGE

As we age, our bodies produce less NAD+ and the communication between the Mitochondria and cell nucleus is impaired. (5,8,10).Over time,  decreasing NAD+ impairs the cell's ability to make energy, which leads to aging and disease (8, 5) and perhaps even the key factor in why we age (5).

Restoring NAD+ levels with Supplements


There is no arguing that boosting NAD+ levels brings an array of health benefits like better focus and memory, better sleep, more energy, and a faster metabolism.

Restoring NAD+ levels has been shown in research with mice to be effective at combatting many age related disease such as Parkinson’s, Alzheimers, heart disease diabetes, cancer, and more.

This research published March 2018 gave NMN to old mice for 2 months and found their strength and endurance nearly doubled (r).

Examination of their muscles showed they were indistinguishable from those of young mice. They also grew new blood vessels and vastly increased capillary density.

Does it work as well in humans as in mice?

Dozens of clinical trials are going on now, but it takes years to get approval, conduct and publish research. The first studies with humans demonstrated that the precursors NR and NMN could safely elevate NAD+ levels, but we are waiting for publication of research showing treatment of specific disease.

Metro International Biotech (co-founded by Dr Sinclair) has completed multiple phase 1 studies in humans with their MIB626 (a patented derivative of NMN) but have been keeping the results quiet and are holding off publication for a while longer.

It appears they were successful as they are ready to begin phase 2 testing and file for an IND to treat Freidrichs Ataxia and Mitochondria Myopathy in Mid 2019

Metro International Biotech has conducted multiple IRB-approved human safety and bioavailability trials at a prominent Boston hospital, which demonstrated MIB-626 is well tolerated in healthy human volunteer subjects and raises blood levels of NAD+ and related metabolites.

Bioavailability issues

It has long been known that NAD+ is completely digested in the stomach, so has not been used in oral supplements.

Instead, NAD+ precursors such as Niagen and NMN have been used in research to boost NAD+ and have been available for purchase as a dietary supplement for a few years now.

In February 2018, this thesis by Ling Liu showed that oral supplements of NR and NMN are digested in the stomach and liver, with very little reaching the bloodstream (r).

the main circulating product of the administered NR or NMN was NAM

orally delivered NR and NMN are converted into NAM before reaching the systemic circulation

There is some conflicting research in this January 2019 study that found a dedicated transporter can convert NMN from the small intestine directly to NAD+.

This pathway is upregulated in older animals to compensate for decreased NAD+ levels.

the Slc12a8 NMN transporter becomes crucial in aged individuals compared with young ones. In response to significant decreases in NAD+ levels, the aged ileum upregulates Slc12a8 expression and tries to maintain its NAD+ levels

The Slc12a8 pathway is specific for NMN – NR cannot utilize this shortcut to NAD.

The Slc12a8 shortcut likely explains why research has found NMN can make its way to bloodstream and tissues throughout the body in minutes – far faster than NR.

But it is not yet known how prevalent this transporter is and how much NMN it can process – only that SOME oral supplements of NMN can avoid digestion.

(The Liu thesis research use younger animals, which may explain why they didn’t find any NMN escaped the liver to the bloodstream – Slc12a8 is not “turned on” in healthy, younger animals)

Bioavailability Summary:
  • NAD+ – totally digested in stomach and small intestine
  • NR – digested in GI tract and metabolized to NAM in liver
  • NMN – mostly digested in GI tract and metabolized to NAM in liver, although some can utilize the Slc12a8 shortcut

Sublingual delivery solves bioavailability issues

Sublingual delivery can bypass the digestive system and deliver NAD+ NR, or NMN directly to the bloodstream.

Improved endurance and muscle growth noted

Using our protocol of frequent doses of NMN taken sublingually, we have seen the same restoration of muscle strength and endurance as the mice in this research, in a very short time. My personal experience has been a return to the strength and fitness of my 20’s in just 3 months.

Alivebynature has been the dominant seller of NMN over the last year. From speaking with customers we have discovered that multiple sublingual dosages throughout the day dramatically increases the effectiveness.

 

SUMMARY:

    • Sublingual delivery is required for all NAD+ metabolites and precursors to avoid digestion in the stomach and liver.
    • NAD+ clinics use slow drip IV of NAD+ to avoid the stomach and liver. They are exploding in popularity, but the extreme cost and time required for treatment severely limit their application for the general public.
    • Sublingual NAD+ delivery solves the bioavailability problem and mimics the slow drip delivery used successfully by NAD+ IV clinics.
    • Sublingual NAD+ is not subject to the homeostasis that limits NAD+ increase with NR (and perhaps NMN), as it is supplied directly to the bloodstream.
    • We believe the ability of NAD+ to increase metabolism through the hypothalamus has a great impact on the entire body. This is accomplished directly from increased NAD+ circulating in blood plasma, and not from NMN or NR.
    • Other organs such as heart, liver, kidney, and lungs also clearly benefit from increased circulating NAD+, but there is evidence NR an NMN may have similar effectiveness.
    • Exogenous NR increases circulating NAD+ levels, but after several weeks, that increase is severely limited by homeostasis.
    • Exogenous NMN elevates NAD+ levels similar to NR, but seems to be less limited by homeostasis. Publication of recently completed research should shed more light on that question.


NMN demonstrates a remarkable ability to rapidly restore vascular growth that has not been shown with use of NR or NAD+.

 

Sublingual NAD+ will lead to a greater increase in circulating NAD+ than NR or NMN supplements.