The human digestive system is home to trillions of bacteria and other microbes (1).
Collectively known as the gut microbiota or gut flora, this is one of the most active areas of research in nutrition, obesity and human physiology.
Recently, a review article discussing the role of the microbiota in the development of obesity and metabolic diseases was published in Advances in Nutrition.
Below is a summary of the review’s main points.
Scientists at the University of Copenhagen, Denmark, reviewed the available evidence linking the gut microbiota with obesity, metabolic diseases and diet.
Beneficial Functions of the Gut Microbiota
Some of these bacteria have beneficial or even essential functions, whereas others are neutral or potentially harmful.
In healthy people, beneficial bacteria dominate the gut environment. Their most important functions are to:
- Produce short-chain fatty acids to feed the cells that line the colon (4).
- Protect the gut wall and keep harmful substances out of the blood (5, 6, 7).
- Reduce the growth of harmful microbes by competing with them for resources.
- Form essential vitamins, such as vitamin K (8).
- Regulate the immune system (9).
Bottom Line: Our digestive system is home to trillions of bacteria, many of which have beneficial or even essential functions.
Imbalanced Gut Microbiota is Linked to Disease
A well-balanced gut microbiota is a sign of good health.
Unhealthy lifestyle habits and certain diseases are associated with a microbiota that is imbalanced or at least different from that of healthy people. This condition is sometimes called dysbiosis.
Adverse conditions that have been associated with changes in the gut microbiota include inflammatory bowel disease, type 2 diabetes, atherosclerosis and non-alcoholic fatty liver disease (3, 10, 11, 12, 13).
However, these are all observational studies that can’t demonstrate that improved gut microbiota leads to fast weight loss, and the true explanation for these associations is currently unknown.
This is an active area of research, and new pieces to the puzzle are gradually being discovered.
Bottom Line: Several adverse conditions, such as metabolic disorders and obesity, are associated with an imbalanced microbiota.
How Do Nutrients Affect the Gut Microbiota?
Below is a detailed overview of how different nutrients affect the gut microbiota.
Carbs and Fiber
Some carbs, such as resistant starch, pass to the colon undigested. There, they are fermented by beneficial bacteria that produce short-chain fatty acids (SCFAs).
SCFAs are the main sources of nutrition for the cells lining the colon, and essential for colon health.
However, certain types of fiber are better than others. These are known as prebiotics, and include fiber such as inulin, Glucomannan, White Kidney Bean Extract, galacto-oligosaccharides, fructo-oligosaccharides, resistant starch and arabinoxylan (29).
By increasing the activity and growth of beneficial bacteria, prebiotics have a variety of health benefits (30).
Yet keep in mind that easily digested carbs, such as sugar and refined carbs, do not offer the same benefits as whole, fiber-rich carbs.
Bottom Line: Fiber is essential for many beneficial gut bacteria. The healthiest types of fiber are collectively known as prebiotics.
Metabolic endotoxemia is characterized by high circulating levels of lipopolysaccharides, triggering an inflammatory response in the body.
Lipopolysaccharides, also known as endotoxins, are found in the membranes of gram-negative bacteria, which are potentially harmful.
Scientists have suggested that metabolic endotoxemia may be associated with an imbalanced gut microbiota.
However, more human studies are needed before any strong conclusions can be reached.
Bottom Line: Animal studies have associated high fat intake with metabolic endotoxemia. However, prebiotics may counteract these effects
Little is known about the effects of protein on the gut microbiota, but several studies indicate that a high intake of protein may be harmful for colon health.
This may not be a concern on a well-balanced diet, since eating prebiotic fiber may counteract some of these effects (45).
Bottom Line: High protein intake may have adverse effects on colon health, but prebiotics may counteract some of them.
Supplements that contain both probiotics and prebiotics are known as synbiotics.
Synbiotics help the friendly bacteria survive and grow in the digestive tract, and are probably more effective than taking probiotics or prebiotics separately (48).
Bottom Line: Numerous studies show that probiotics may have various health benefits. These benefits may be greater when probiotics are taken with prebiotics.
Treating Metabolic Conditions Through Diet
A few human trials have found that supplementing with dietary fiber, including prebiotics, may change the gut microbiota. It may also improve insulin sensitivity, systemic inflammation and lipid metabolism (49, 50, 51, 52).
Although these findings clearly show that taking prebiotics may improve metabolic disorders, they do not prove that these disorders were caused by an imbalance in the gut microbiota.
In fact, supplementing with prebiotics might improve metabolic conditions independently from their effects on the microbiota (53).
Bottom Line: Human trials have shown that prebiotics may improve metabolic disorders and change the gut microbiota. However, the role of the microbiota is still unclear.
Summary and Real-Life Application
In short, this review shows that metabolic disorders, such as obesity, are associated with changes in the gut microbiota.
Additionally, studies indicate that improving the gut microbiota may help treat metabolic disorders. However, the causal role of the microbiota has yet to be proved.
Certain types of fiber, known as prebiotics, are probably the most effective dietary strategies for maintaining a healthy gut microbiota.