Frequently Asked Questions about Nicotinamide Adenine Dinucleotide (NAD⁺) and Nicotinamide Mononucleotide (NMN)

 

Common Questions

What is NAD⁺?

NAD⁺ is a coenzyme that is present in all living cells. Supplementing NAD⁺ levels leads to healthier cells. NAD⁺ levels decline naturally as we age. NAD⁺ works with the cell to bolster vital cellular processes leading to DNA optimization, sleep pattern regulation and energy formation.

What is NMN?

NMN is a precursor molecule to NAD+. NMN works synergistically at the cellular level to increase sirtuin activity, optimize mitochondrial function, and restore levels of NAD+ as they were in youth. 

Can NAD⁺ and NMN be taken together?

NMN and NAD⁺ have no known side effects or contraindications when taken together or separately.

Why sublingual delivery?

Humans only absorb 20% of nutrients we ingest through digestive system. Sublingual delivery is revolutionary – by avoiding first pass of the digestive system, NMN and NAD⁺ are absorbed directly into the bloodstream.

Are your products made in the USA?

Yes.

All of our raw ingredients are made and manufactured in the United States, and all of our products are manufactured in the United States under rigorous pharmaceutical and cGMP protocols.

All of our formulations are 100% natural and made by a patented, solvent-free based process.

Does the sublingual powder come with a scoop?

Yes.

To prevent contamination, we do not include the scoop in the jar itself.

It is best to keep the measuring scoop separate from the product.

We choose to follow pharmaceutical guidelines and offer scoops that are individually wrapped, which accompany the jar.

What is the role of the enzyme Slc12a8 in NMN transportation?

This research was published in January 2019 that found an enzyme named Slc12a8 that can transport a small quantity of Nicotinamide Mononucleotide (NMN) directly into some cells.

However, this enzyme is only prevalent in the small intestine of older, sicker animals and humans.

The Slc12a8 enzyme was just discovered because it plays a very minor role, and does not transport a large enough quantity of NMN to have been noticed earlier.

Does NAD⁺ increase incidences of cancer?
There are theories based on research in test tubes that increased NAD⁺ may provide tumors with energy for faster growth.
 
In reality, there have been no experiments in live animals showing this. In fact, all studies in mice and humans have found no increased incidence, severity, or decreased mortality due to cancer.
 
In response to this question, Dr. Sinclair states: “Johan Auwerx and I only see health benefits and lifespan extension in mice when we give NR or NMN to old mice. Fasting and exercise raise NAD⁺ and they don’t accelerate aging or cancer.
Do PURE NAD⁺ and NMN Powders have any effect on tooth enamel?

NAD⁺ and NMN need to be slightly acidic, both to maintain stability, and improve sublingual absorption.

Our products vary between 4.0 and 4.5 pH, which is similar to the acidity of tomatoes on the pH scale.

Prolonged exposure could in theory contribute to loss of enamel, but less so than more acidic foods such as lemons or oranges.

The sublingual powder should be placed under the tongue to dissolve. It should not come in contact with the teeth.

 

Nicotinamide Adenine Dinucleotide (NAD⁺)

 

PURE NAD⁺ Sublingual Tablets

What ingredients are in NAD⁺ Sublingual Tablets?

The only ingredients in NAD⁺ tablets are the NAD⁺ molecule itself and excipients essential to the formation of the tablet.

How much do I take?

Recommended daily dosages of sublingual NAD⁺ are at least 400 mg, which equates to 3-4 tablets per day at minimum.

 

PURE NAD⁺ Powder

What ingredients are in PURE NAD⁺ Powder?

The only ingredient in PURE NAD⁺ Powder is the NAD⁺ molecule itself.

How much do I take?

Recommended daily dosages of sublingual NAD⁺ are at least 400 mg, which equates to 3-4 scoops of PURE NAD⁺ Powder.

 

Liquid NAD⁺ Drops

What ingredients are in Liquid NAD⁺ Drops?

Liquid NAD⁺ contains the molecule itself and organic non – GMO pharmaceutical gradeexcipients that are a natural way to ensure self-life and potency.

How much do I take?

We chose to keep the glass pipette free of markings so the Liquid NAD⁺ does not come into contact with dye.

For the .5mL serving size, simply fill halfway and place under the tongue to dissolve.

Half full is .5mL, which delivers a 125 mg serving of NAD⁺.

We recommend 3-4 doses per day.

 

PURE NAD⁺ Nasal Spray

What ingredients are in PURE NAD⁺ Nasal Spray?

PURE NAD⁺ Nasal Spray contains the molecule itself and organic non – GMO pharmaceutical grade excipients that are a natural way to ensure self-life and potency. The Nasal Spray is safe and effecatious in the nasal cavity, subject to rigourous third party testing.

How much do I take?

Two sprays of NAD⁺ Micromist deliver 12.5 mg each directly to the blood brain barrier, constituting a serving of 25 mg.

We recommend 3-4 servings per day.

 

Nicotinamide Mononucleotide (NMN)

 

PURE NMN Powder

What ingredients are in PURE NMN Powder?

The only ingredient in PURE NMN Powder is the NMN molecule itself.

How much do I take?

Recommended daily dosages of sublingual NMN are at least 400 mg, which equates to 3-4 scoops of PURE NMN Powder.

 

PURE NMN Sublingual Tablets

What ingredients are in PURE NMN Sublingual Tablets?

The only ingredients in NMN tablets are the NMN molecule itself and an excipient essential to the formation of the tablet.

How much do I take?

Recommended daily dosages of sublingual NMN are at least 400 mg, which equates to 3-4 tablets per day at minimum.

 

NAD⁺ Optimizer Series

 

NAD⁺ Activator

 

NAD⁺ Energizer

 

NAD⁺ Defender

What ingredients are in NAD⁺ Defender?

MSM – Methylsulfonylmethane

Methylsulfonylmethane decreases inflammatory response to tumor necrosis factor-α in cardiac cells.

Micronized Curcumin

Curcumin aids in the management of oxidative and inflammatory conditions.

Boswellia Serrata

Boswellia Serratta contains acids responsible for inhibition of pro-inflammatory enzymes.

Berberine

Berberine regulates glucose and lipid metabolism.

Silibinin (from Milk Thistle)

Silibinin Restores NAD+ levels and induces the
SIRT1/AMPK pathway in non-alcoholic fatty liver, while also increasing the bioavailability of Berberine.

Piperine

Piperine is used to
increase bioavailability of Curcumin.

 

How much do I take?

It is recommended to take 2-4 capsules per day at 650 mg each to suppress chronic inflammation which research shows is the leading consumer of NAD⁺ as we age.