NAD+ Forums

In a new study in the scientific journal Nature Communications, an international team of researchers from, among others, the University of Copenhagen and the National Institutes of Health in the United States, has come closer to a new way of attacking the disease. The researchers have looked at a cl...

This prospective, randomized, placebo-controlled, exploratory study was conducted to test the hypothesis that a topical application of rapamycin (10 μM) would decrease the number of senescent cells in the skin and decrease markers of aging. Thirty-six participants were enrolled in the study, and nin...

In this article by Josh Mitteldorf, he claims there remain unanswered questions from Sinclair's recent Epigenetic mouse experiments and whether Sinclair has in fact told us everything. For example, in Sinclair's experiment to reset the mouse epigenome in the optic nerve, 3 of the 4 Yamanaka factors...

resTORbio Announces That the Phase 3 PROTECTOR 1 Trial of RTB101 in Clinically Symptomatic Respiratory Illness Did Not Meet the Primary Endpoint RTB101 were inhibiting mTORC1, to minimize side effects of whole TOR inhibition, and targeting respiratory illness. https://ir.restorbio.com/news-releases/...

Ergothioneine(ESH) Pyrroloquinoline quinone Queuine Lutein Zeaxanthin Lycopene α-carotene β-Carotene β-cryptoxanthin Astaxanthin "It is proposed that proteins/enzymes be classified into two classes according to their essentiality for immediate survival/reproduction and their function in long-term he...

Lautrup et al. link NAD+ to the ten hallmarks of brain aging, summarize the effects of NAD+ augmentation on brain disorders, and point to NAD+-based clinical trials and future perspectives. https://www.sciencedirect.com/science/article/abs/pii/S1550413119305029 NAD+ is a pivotal metabolite involved ...

Fisetin is also a senolytic drug, I don't think you should take it on a daily basis. Take it a few days each month instead, you can refer to joko's post for more information. viewtopic.php?t=699

There is a recent paper shows that hyperinsulinemia (high blood insulin level) can cause cell senescence in the brain, which offers a direct connection between peripheral hyperinsulinemia, as found in prediabetes, age-related neurodegeneration and cognitive decline. https://www.nature.com/articles/s...

Here, a group report results of a late-life DR-switch experiment using 800 mice. Female mice aged 24 months were switched from an ad libitum (AL) diet to dietary restriction (DR) or vice versa. Strikingly, the switch from DR to AL acutely increases mortality , whereas the switch from AL to DR causes...

These questions cannot be answered until large-scaled human trials have been done. But based on the current model of how NAD+ and sirtuin work, the answer to the first question is: unlikely. Based on the epigenetic theory of aging, aging is a result of the random events that happen after DNA damage...