NAD+ Forums

This human study shows that long-term treatment with dulaglutide might reduce cognitive impairment in people with type 2 diabetes. This is the first treatment proven efficacy in attenuating cognitive decline in people with diabetes. https://www.sciencedirect.com/science/article/abs/pii/S147444222030...

It is known that severe CR is detrimental in very old age. And metformin can block the beneficial effects of exercise. Recent research suggests it might also be the case for a high dose of NMN. All of this evidence suggests that we shouldn't blindly combine longevity regimes, especially for older pe...

New study shows that sucrose (table sugar), not fat, is the main driver of atherosclerosis in hyperlipidemic mice. We fed pro-atherogenic LDLr−/− ApoB100/100 mice either a low-fat/high-sucrose (LFHS) or a high-fat/low-sucrose (HFLS) diet for 24 weeks. HFLS feeding increased obesity, insulin resistan...

This study shows that NR corrects social deficits and fearful and anxiety-like behaviours in mouse model of autism spectrum disorder. These results suggest that elevating NAD levels with nicotinamide riboside may allow animals with cADPR- and OT-forming deficits to overcome these deficits and functi...

Here is the comment on the paper above.

https://blogs.sciencemag.org/pipeline/a ... ent-321890

"Overall, I still find such results hard to believe, but at the same time they seem to be showing up from multiple experiments. "

https://pubmed.ncbi.nlm.nih.gov/32467649/ This is a really good review paper that systemically reviewed known anti-aging drugs. In this review paper, the authors summarized recent efforts on identifying compounds with longevity properties. They then selected a few longevity compounds from animal stu...

This paper provides the mechanism of anti-cancer property of fisetin. https://pubmed.ncbi.nlm.nih.gov/32530958/ Fisetin was previously reported to induce the p53-mediated apoptotic pathway in human renal carcinoma cells [40]. Yet, the underlying mechanism and direct connection to SUMO1 has not been ...

Very low-carbohydrate, high-fat ketogenic diets (KDs) induce a pronounced shift in metabolic fuel utilization that elevates circulating ketone bodies; however, the consequences of these compounds for host-microbiome interactions remain unknown. Here, we show that KDs alter the human and mouse gut mi...

Hi jessicaP, welcome to the forum. There were some reports said long-term fasting is more difficult for female than male, probably due to sex difference. It would be interesting if NAD precursor plays a role in helping fasting, great to hear!

/quote] Actually, it makes a lot of sense. If you look at the expression level of Slc12a8 (the transport of NMN on the cell membrane) across different tissue, the pancreas is one of the top three organs with the highest expression level of l. https://i.postimg.cc/d7bqq5dJ/Screen-Shot-2020-06-04-at-...