Search found 141 matches

by AlbertY
Mon Jun 29, 2020 9:15 pm
Forum: Healthy Aging News and Research
Topic: REWIND trial: dulaglutide on cognitive impairment in T2D
Replies: 0
Views: 54

REWIND trial: dulaglutide on cognitive impairment in T2D

This human study shows that long-term treatment with dulaglutide might reduce cognitive impairment in people with type 2 diabetes. This is the first treatment proven efficacy in attenuating cognitive decline in people with diabetes. https://www.sciencedirect.com/science/article/abs/pii/S147444222030...
by AlbertY
Mon Jun 29, 2020 8:51 pm
Forum: NAD+ Optimizers
Topic: High dose of metformin with the SIRT1 activator reduces lifespan
Replies: 1
Views: 95

High dose of metformin with the SIRT1 activator reduces lifespan

It is known that severe CR is detrimental in very old age. And metformin can block the beneficial effects of exercise. Recent research suggests it might also be the case for a high dose of NMN. All of this evidence suggests that we shouldn't blindly combine longevity regimes, especially for older pe...
by AlbertY
Mon Jun 22, 2020 2:23 pm
Forum: Nutrition
Topic: One more reason to avoid surgar!
Replies: 10
Views: 366

One more reason to avoid surgar!

New study shows that sucrose (table sugar), not fat, is the main driver of atherosclerosis in hyperlipidemic mice. We fed pro-atherogenic LDLr−/− ApoB100/100 mice either a low-fat/high-sucrose (LFHS) or a high-fat/low-sucrose (HFLS) diet for 24 weeks. HFLS feeding increased obesity, insulin resistan...
by AlbertY
Mon Jun 22, 2020 2:16 pm
Forum: NR
Topic: NR supplementation improves autism spectrum disorder
Replies: 0
Views: 150

NR supplementation improves autism spectrum disorder

This study shows that NR corrects social deficits and fearful and anxiety-like behaviours in mouse model of autism spectrum disorder. These results suggest that elevating NAD levels with nicotinamide riboside may allow animals with cADPR- and OT-forming deficits to overcome these deficits and functi...
by AlbertY
Wed Jun 17, 2020 5:38 pm
Forum: Healthy Aging News and Research
Topic: Young blood plasma fraction reverse the epigenetic age of rats by 54%
Replies: 7
Views: 2958

Re: Young blood plasma fraction reverse the epigenetic age of rats by 54%

Here is the comment on the paper above.

https://blogs.sciencemag.org/pipeline/a ... ent-321890

"Overall, I still find such results hard to believe, but at the same time they seem to be showing up from multiple experiments. "
by AlbertY
Wed Jun 17, 2020 4:49 pm
Forum: Longevity
Topic: The quest to slow ageing through drug discovery
Replies: 4
Views: 1370

The quest to slow ageing through drug discovery

https://pubmed.ncbi.nlm.nih.gov/32467649/ This is a really good review paper that systemically reviewed known anti-aging drugs. In this review paper, the authors summarized recent efforts on identifying compounds with longevity properties. They then selected a few longevity compounds from animal stu...
by AlbertY
Sat Jun 13, 2020 3:55 pm
Forum: Senolytics
Topic: Fisetin blocks sumoylation of tumor suppressor p53 and promote its activity
Replies: 0
Views: 1327

Fisetin blocks sumoylation of tumor suppressor p53 and promote its activity

This paper provides the mechanism of anti-cancer property of fisetin. https://pubmed.ncbi.nlm.nih.gov/32530958/ Fisetin was previously reported to induce the p53-mediated apoptotic pathway in human renal carcinoma cells [40]. Yet, the underlying mechanism and direct connection to SUMO1 has not been ...
by AlbertY
Thu Jun 11, 2020 2:14 pm
Forum: Nutrition
Topic: Keto diet reduces the levels of intestinal pro-inflammatory cells.
Replies: 6
Views: 2004

Keto diet reduces the levels of intestinal pro-inflammatory cells.

Very low-carbohydrate, high-fat ketogenic diets (KDs) induce a pronounced shift in metabolic fuel utilization that elevates circulating ketone bodies; however, the consequences of these compounds for host-microbiome interactions remain unknown. Here, we show that KDs alter the human and mouse gut mi...
by AlbertY
Thu Jun 11, 2020 1:49 pm
Forum: Fasting
Topic: Fasting and Ellyptical
Replies: 6
Views: 1933

Re: Fasting and Ellyptical

Hi jessicaP, welcome to the forum. There were some reports said long-term fasting is more difficult for female than male, probably due to sex difference. It would be interesting if NAD precursor plays a role in helping fasting, great to hear!
by AlbertY
Fri Jun 05, 2020 3:03 pm
Forum: NMN
Topic: One pill a day could cure Type II Diabetes
Replies: 14
Views: 2835

Re: One pill a day could cure Type II Diabetes

/quote] Actually, it makes a lot of sense. If you look at the expression level of Slc12a8 (the transport of NMN on the cell membrane) across different tissue, the pancreas is one of the top three organs with the highest expression level of l. https://i.postimg.cc/d7bqq5dJ/Screen-Shot-2020-06-04-at-...