Search found 67 matches

by AlbertY
Sun Dec 08, 2019 1:27 pm
Forum: NAD+
Topic: New research shows that NAD+ supplementation can slow Wernersyndrome (a progeria disease) in mice
Replies: 1
Views: 26

New research shows that NAD+ supplementation can slow Wernersyndrome (a progeria disease) in mice

In a new study in the scientific journal Nature Communications, an international team of researchers from, among others, the University of Copenhagen and the National Institutes of Health in the United States, has come closer to a new way of attacking the disease. The researchers have looked at a cl...
by AlbertY
Mon Nov 25, 2019 7:46 pm
Forum: Longevity
Topic: Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial
Replies: 6
Views: 196

Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial

This prospective, randomized, placebo-controlled, exploratory study was conducted to test the hypothesis that a topical application of rapamycin (10 μM) would decrease the number of senescent cells in the skin and decrease markers of aging. Thirty-six participants were enrolled in the study, and nin...
by AlbertY
Sun Nov 24, 2019 7:48 pm
Forum: Longevity
Topic: Unanswered Questions Remain from Sinclair's Recent Epigenetic Mouse Experiments
Replies: 10
Views: 706

Re: Unanswered Questions Remain from Sinclair's Recent Epigenetic Mouse Experiments

In this article by Josh Mitteldorf, he claims there remain unanswered questions from Sinclair's recent Epigenetic mouse experiments and whether Sinclair has in fact told us everything. For example, in Sinclair's experiment to reset the mouse epigenome in the optic nerve, 3 of the 4 Yamanaka factors...
by AlbertY
Sun Nov 24, 2019 11:34 am
Forum: Longevity
Topic: mTOR inhibition Phase 3 clinical trial fails.
Replies: 2
Views: 95

mTOR inhibition Phase 3 clinical trial fails.

resTORbio Announces That the Phase 3 PROTECTOR 1 Trial of RTB101 in Clinically Symptomatic Respiratory Illness Did Not Meet the Primary Endpoint RTB101 were inhibiting mTORC1, to minimize side effects of whole TOR inhibition, and targeting respiratory illness. https://ir.restorbio.com/news-releases/...
by AlbertY
Fri Nov 15, 2019 9:05 pm
Forum: Longevity
Topic: Ten Longevity vitamins by Bruce N. Ames
Replies: 11
Views: 415

Ten Longevity vitamins by Bruce N. Ames

Ergothioneine(ESH) Pyrroloquinoline quinone Queuine Lutein Zeaxanthin Lycopene α-carotene β-Carotene β-cryptoxanthin Astaxanthin "It is proposed that proteins/enzymes be classified into two classes according to their essentiality for immediate survival/reproduction and their function in long-term he...
by AlbertY
Sat Nov 09, 2019 11:13 am
Forum: NAD+
Topic: link NAD+ to the ten hallmarks of brain aging
Replies: 1
Views: 817

link NAD+ to the ten hallmarks of brain aging

Lautrup et al. link NAD+ to the ten hallmarks of brain aging, summarize the effects of NAD+ augmentation on brain disorders, and point to NAD+-based clinical trials and future perspectives. https://www.sciencedirect.com/science/article/abs/pii/S1550413119305029 NAD+ is a pivotal metabolite involved ...
by AlbertY
Sun Nov 03, 2019 5:21 pm
Forum: NMN
Topic: AMPK Activator
Replies: 7
Views: 1239

Re: AMPK Activator

Fisetin is also a senolytic drug, I don't think you should take it on a daily basis. Take it a few days each month instead, you can refer to joko's post for more information. viewtopic.php?t=699
by AlbertY
Thu Oct 31, 2019 7:02 pm
Forum: Healthy Aging News and Research
Topic: New insight into type 2 diabetes and hyperinsulinemia
Replies: 5
Views: 1958

New insight into type 2 diabetes and hyperinsulinemia

There is a recent paper shows that hyperinsulinemia (high blood insulin level) can cause cell senescence in the brain, which offers a direct connection between peripheral hyperinsulinemia, as found in prediabetes, age-related neurodegeneration and cognitive decline. https://www.nature.com/articles/s...
by AlbertY
Wed Oct 23, 2019 6:12 pm
Forum: Nutrition
Topic: A nutritional memory effect counteracts the benefits of dietary restriction in old age
Replies: 0
Views: 872

A nutritional memory effect counteracts the benefits of dietary restriction in old age

Here, a group report results of a late-life DR-switch experiment using 800 mice. Female mice aged 24 months were switched from an ad libitum (AL) diet to dietary restriction (DR) or vice versa. Strikingly, the switch from DR to AL acutely increases mortality , whereas the switch from AL to DR causes...
by AlbertY
Mon Oct 21, 2019 1:20 pm
Forum: NMN
Topic: Important question regarding extended use of NMN or NR
Replies: 22
Views: 4640

Re: Important question regarding extended use of NMN or NR

These questions cannot be answered until large-scaled human trials have been done. But based on the current model of how NAD+ and sirtuin work, the answer to the first question is: unlikely. Based on the epigenetic theory of aging, aging is a result of the random events that happen after DNA damage...