Search found 82 matches

by AlbertY
Thu Jan 16, 2020 8:37 pm
Forum: Longevity
Topic: Twice daily 500 mg resveratrol improves metabolic markers in T1D patients
Replies: 0
Views: 39

Twice daily 500 mg resveratrol improves metabolic markers in T1D patients

Twice daily 500 mg resveratrol for 60 days significantly decreased fasting blood sugar, hemoglobin A1c (HbA1c), and a marker for oxidative stress, malondialdehyde, in patients with type 1 diabetes. Resveratrol has been reported to be beneficial against diabetes complications. The objective of this s...
by AlbertY
Tue Jan 14, 2020 8:21 am
Forum: NAD+
Topic: novel therapeutic approach to increase tissue NAD+/NADH ratio
Replies: 1
Views: 62

novel therapeutic approach to increase tissue NAD+/NADH ratio

Here is a research published yesterday about rising the cellular NAD+ level by transforming lactate into pyruvate in the bloodstream. An elevated intracellular NADH:NAD+ ratio, or ‘reductive stress’, has been associated with multiple diseases, including disorders of the mitochondrial electron transp...
by AlbertY
Fri Jan 10, 2020 9:41 am
Forum: NAD+
Topic: Short-term NAD+ supplementation prevents hearing loss in mouse models of progeria
Replies: 3
Views: 770

Re: Short-term NAD+ supplementation prevents hearing loss in mouse models of progeria

This new study shows that 10 day NR treatment is sufficient to prevent hearing loss in mouse models of progeria. Age-related hearing loss (ARHL) is one of the most common disorders affecting elderly individuals. There is an urgent need for effective preventive measures for ARHL because none are cur...
by AlbertY
Tue Jan 07, 2020 9:29 am
Forum: NAD+
Topic: Short-term NAD+ supplementation prevents hearing loss in mouse models of progeria
Replies: 3
Views: 770

Short-term NAD+ supplementation prevents hearing loss in mouse models of progeria

This new study shows that 10 day NR treatment is sufficient to prevent hearing loss in mouse models of progeria. Age-related hearing loss (ARHL) is one of the most common disorders affecting elderly individuals. There is an urgent need for effective preventive measures for ARHL because none are curr...
by AlbertY
Thu Jan 02, 2020 6:24 am
Forum: Healthy Aging News and Research
Topic: When does aging begin? This research might give us anwser
Replies: 3
Views: 492

Re: When does aging begin? This research might give us anwser

And the methylation clock starts ticking when we were embryos
by AlbertY
Thu Jan 02, 2020 6:22 am
Forum: Healthy Aging News and Research
Topic: When does aging begin? This research might give us anwser
Replies: 3
Views: 492

When does aging begin? This research might give us anwser

An increase in the probability of death has been a defining feature of aging, yet human perinatal mortality starts high and decreases with age. Previous evolutionary models suggested that organismal aging begins after the onset of reproduction. However, we find that mortality and incidence of disea...
by AlbertY
Thu Jan 02, 2020 6:02 am
Forum: Healthy Aging News and Research
Topic: Dr. Ocampo: predictions on the aging field for the next 10 years
Replies: 1
Views: 386

Dr. Ocampo: predictions on the aging field for the next 10 years

1. TAME trial: metformin will not be the best anti-aging drug but will pave the regulatory way for future anti-aging trials with "real" anti-aging endpoints 2. Dog Aging Project: this clinical trial will demonstrate significant effects of rapamycin on lifespan and the onset of age-related diseases i...
by AlbertY
Thu Jan 02, 2020 5:58 am
Forum: Senolytics
Topic: Incredible New Mayo Clinic Study on Senolytics
Replies: 11
Views: 1311

Re: Incredible New Mayo Clinic Study on Senolytics

Thank you, Jocko. A few weeks ago, Dr. Kirkland (leader of senolytics study in Mayo) had a talk in my school about the translation of senolytic drugs. So excited to see the result of the clinical trials!
by AlbertY
Thu Jan 02, 2020 5:49 am
Forum: NAD+
Topic: NAD or NMN for mid 30's male
Replies: 5
Views: 617

Re: NAD or NMN for mid 30's male

There are evidences show that NMN can ameliorate imflamation and depression. Some people also claim that NMN can improve sleep quality. So, good news is you are at right place.

According to Professor David Sinclair, you should consider take 1 gram of NMN daliy.
by AlbertY
Tue Dec 31, 2019 8:13 am
Forum: Fasting
Topic: The Best intermittent fasting reviewing article
Replies: 3
Views: 1739

Re: The Best intermittent fasting reviewing article

Thank you AlbertY! Great paper. Reading it now with a hot mug of instant espresso (yes, instant coffee contains more beneficial polyphenols than fresh coffee. Instant is more concentrated in caffeic acid and chlorogenic acid for example). The neuroscientist Mark Mattsson, Dr Satchin Panda at the Sa...