NAD+ Forums

Hi all, recently there is not much interesting news about aging research and labs in Harvard med school will be closed for the next few months. Hope everyone stays safe! Recently I'm working on a project about the COVID19, data is unpublished so I can't talk too much here but we found that the ACE2,...

Yea makes sense. Exercises + good mood!

Thanks for sharing AlbertY! Anecdotally, do you know of any menopausal or post menopausal human females who have taken the molecules and had their fertility restored or any that may have actually gone on to fall pregnant and have a successful live birth? Heard Dr. David Sinclair mentioned that once.

I've always 'heard' that taking milk with tea cancels out a lot of the benefits of tea? Is anyone aware of studies showing evidence of this? My bladder cannot deal with milk-free tree. I don't think so, a very recent epi study shows drinking low-fat milk -- both nonfat and 1% milk -- is significant...

Here, we mined the data and performed a deep in silico analysis to identify drugs highly likely to induce cardiac regeneration. Fisetin was identified as the top candidate. We validated its effects in an in vitro model of MI/IRI in mammalian cardiac cells. Fisetin enhances viability of rat cardiomy...

Saw this paper during an aging lecture: Tissue-specific regulation of SIRT1 by calorie restriction https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492662/ Calorie restriction (CR) has been reported to increase SIRT1 protein levels in mice, rats, and humans, and elevated activity of SIRT1 orthologs ext...

jocko6889 wrote: ↑

Sun Feb 16, 2020 2:02 am

Interesting chart and makes sense. ABN will introduce liposomal Fisetin in March which will be 47x more bioavailable. Might be a great way to bring senescent levels down.

Wow that sounds promising, will ABN have a human trial (even a small one) for that maybe?

thanks albert- very interesting. I share your intuition that hypothalamus may be a key regulator of aging. You probably know about this study below. It shows very small dose of NAD+ enters hypothalamus intact and restores NAD+ levels. Hope to see more longer term studies on this soon. Exogenous nic...

htNSC regulates aging by secreting small vesicles (exosomes) containing RNAs, I believe the beneficial effect of young blood infusion at least partially come from here. Interested to see whether NAD+ can help maintain htNSC as well, since NAD+ generally maintain stemcells, maybe I should just sugges...

Most of you might never heard of hypothalamic stem cell. hypothalamic neuronal stem cell, aka htNSC, is a group of stem cells located in the hypothalamus. One paper published in 2017 first shows that the numbers of htNSCs decreased during aging and by replenishing htNSCs in mice, it is sufficient to...