Search found 409 matches

by Fred
Sat Feb 22, 2020 5:23 am
Forum: Longevity
Topic: Sinclair: oleic acid is 10 to 100 times more potent than resveratrol
Replies: 1
Views: 58

Sinclair: oleic acid is 10 to 100 times more potent than resveratrol

I like this recent interview with David Sinclair because it was very practical and detailed...he even showed the NMN capsules he swallows with coffee and the little jar and spoon he takes his homemade yogurt and resveratrol with. He says that oleic acid from olive oil, avocado and walnuts are 10 to ...
by Fred
Sun Feb 16, 2020 2:30 am
Forum: NMN
Topic: Small dose of NMN restores fertility in old mice, large dose does not – implications for dosage suggestions
Replies: 8
Views: 571

Re: Small dose of NMN restores fertility in old mice, large dose does not – implications for dosage suggestions

First I've heard that excessive NMN can inhibit sirtuins through increased NAM. I wonder if the increased bioavailability of liposomal NMN would mean we should use smaller doses? But we don't even know the bioavailability of regular NMN, right? There are no human data published on pharmacokinetics ...
by Fred
Sat Feb 15, 2020 9:09 am
Forum: NMN
Topic: NMN Supplementation Promotes Neurovascular Rejuvenation
Replies: 2
Views: 194

NMN Supplementation Promotes Neurovascular Rejuvenation

"Nicotinamide Mononucleotide (NMN) Supplementation Promotes Neurovascular Rejuvenation in Aged Mice: Transcriptional Footprint of SIRT1 Activation, Mitochondrial Protection, Anti-Inflammatory, and Anti-Apoptotic Effects" https://i.postimg.cc/WDqhSbGX/Image-from-10-1007-s11357-020-00165-5-page-13.png...
by Fred
Sat Feb 15, 2020 3:03 am
Forum: Longevity
Topic: NAD+, cancer and aging. New paper by Sinclair
Replies: 2
Views: 249

Re: NAD+, cancer and aging. New paper by Sinclair

"Clearly, more work is required to determine whether raising or decreasing NAD+ levels will be beneficial for the treatment of cancer in humans and which specific pools of NAD+ influence tumorigenesis." "Increasing NAD+ levels has been shown to protect mice from metabolic decline in mouse models of ...
by Fred
Sat Feb 15, 2020 1:26 am
Forum: NMN
Topic: Weight vs volume
Replies: 10
Views: 2407

Re: Weight vs volume

We take it with full fat milk, but since dairy isn't your thing, how about having it with a handful of nuts? Some good fats in nuts, I think? Are we talking about resveratrol now? Because NMN is water soluble and doesn't need to be taken with anything. And 1/2 a teaspoon of megaresveratrol.net is 1...
by Fred
Fri Feb 14, 2020 11:13 am
Forum: NMN
Topic: Weight vs volume
Replies: 10
Views: 2407

Re: Weight vs volume

1 g is 1 g, regardless of volume. It seems that 1 g have the volume of about 5 ml then, according to ABN. My scale doesn't have 0.1 g precision. I think the 1/4 tsp of NMN is just approximately 1 gram right? You don't need to be super accurate here. And yes, other kinds of fat just works the same. Y...
by Fred
Fri Feb 14, 2020 11:08 am
Forum: Longevity
Topic: Protandim
Replies: 4
Views: 149

Re: Protandim

Absolutely kris, I wasn't implying or thinking that you advertised it at all. You were just genuinly interested. The product may have benefits, but their business practices are not to my liking.
by Fred
Thu Feb 13, 2020 10:46 pm
Forum: Longevity
Topic: Control of Inflammation and autophagy by NAD+ precursors, metformin, spermidine, rapamycin, and resveratrol
Replies: 11
Views: 545

Re: Control of Inflammation and autophagy by NAD+ precursors, metformin, spermidine, rapamycin, and resveratrol

I've created a separate thread with information about Protandim (click link below) since it doesn't contain metformin, spermidine, rapamycin or resveratrol:

viewtopic.php?f=77&t=1585
by Fred
Thu Feb 13, 2020 10:45 pm
Forum: Longevity
Topic: Protandim
Replies: 4
Views: 149

Protandim

Kris69 asked for some feedback on the product Protandim in another thread so I started with some info here. The proprietary mix of botanicals called Protandim DID extend lifespan in NIA ongoing testing protocol. But it is also owned by a multi-level marketing company. From Wikipedia: "Protandim is a...
by Fred
Thu Feb 13, 2020 12:25 pm
Forum: Longevity
Topic: NAD+, cancer and aging. New paper by Sinclair
Replies: 2
Views: 249

NAD+, cancer and aging. New paper by Sinclair

"Why does cancer risk increase as we age? Frequently attributed to the multi-hit hypothesis and the time required to accumulate genomic mutations, this question is a matter of ongoing debate. Here, we propose that the normal decline in oxidative metabolism during aging constitutes an early and impor...