Search found 183 matches

by Fred
Fri Nov 15, 2019 7:18 am
Forum: NAD+
Topic: Beginning of a new journey
Replies: 114
Views: 19593

Re: Beginning of a new journey

Fred. You may want to “chime in” on this if you are familiar with the product. Your input for complimentary use in conjunction with NAD+ and NMN would be appreciated.. You asked for my input. If you only want your established view reaffirmed then don´t ask me, because I´m always going to give you m...
by Fred
Fri Nov 15, 2019 7:07 am
Forum: NMN
Topic: The Sinclair protocol
Replies: 2
Views: 30

Re: The Sinclair protocol

Thank you.
by Fred
Fri Nov 15, 2019 3:15 am
Forum: NAD+
Topic: Anyone else feeling less anxiety?
Replies: 21
Views: 3358

Re: Anyone else feeling less anxiety?

In this recent study NMN reduced anxiety/fear in aged genetically engineered mice: "Nampt knockdown recapitulates hippocampal cognitive phenotypes in old mice which nicotinamide mononucleotide improves" In our present study, we found that older mice developed a cognitive hypersensitivity following e...
by Fred
Fri Nov 15, 2019 3:07 am
Forum: NMN
Topic: The Sinclair protocol
Replies: 2
Views: 30

The Sinclair protocol

I know that at least one member here follows the Sinclair protocol: 1 g NMN 1 g metformin 1 g resveratrol For those taking these three molecules to target all three longevity and nutrient-sensing pathways: AMPK, sirtuin and mTOR...have you noticed any difference in your health since adding metformin...
by Fred
Thu Nov 14, 2019 6:00 am
Forum: NAD+
Topic: Beginning of a new journey
Replies: 114
Views: 19593

Re: Beginning of a new journey

Sure Newage, I can chime in. Instead of seaweed pills, I would do fasting for enhanced "stemness". Fasting is proven to regenerate large parts of the immune system by stem cell regeneration . It costs nothing, actually you save money on those 5-7 days of only eating vegetable soup/broth. Fasting als...
by Fred
Thu Nov 14, 2019 1:45 am
Forum: NMN
Topic: Post your weight and dosage thread
Replies: 26
Views: 814

Re: Post your weight and dosage thread

The 300 mg/kg of NMN in MICE is equivalent to 24 mg/kg of NMN in humans. Just to clarify, so no one will start taking 20+ grams of NMN a day ^^
by Fred
Thu Nov 14, 2019 1:36 am
Forum: NMN
Topic: The NMN transporter is found: how NMN gets into cells
Replies: 3
Views: 83

Re: The NMN transporter is found: how NMN gets into cells

Slowly increasing activity (pacing) produce more energy for chronic fatigue patients. It´s a good treatment, not a cure. Work with an MD specialised in this syndrome. I wish you the best. Exercise therapy for chronic fatigue syndrome. https://www.ncbi.nlm.nih.gov/pubmed/31577366 For the nutrition an...
by Fred
Wed Nov 13, 2019 6:18 am
Forum: NMN
Topic: The NMN transporter is found: how NMN gets into cells
Replies: 3
Views: 83

The NMN transporter is found: how NMN gets into cells

I haven´t seen this posted before so adding it for those who haven´t read it. The elusive NMN transporter is found Lindsay E. Wu & David A. Sinclair Nature Metabolism volume 1, pages8–9(2019) Strategies to restore levels of the enzyme cofactor nicotinamide adenine dinclueotide (NAD) late in life to ...
by Fred
Wed Nov 13, 2019 5:10 am
Forum: Longevity
Topic: How to get your daily dose of spermidine to extend life and health
Replies: 4
Views: 77

Re: How to get your daily dose of spermidine to extend life and health

Sounds perfect. And if you want to heat it, you can always reactivate the other beneficial fytonutrient sulphoraphane in cruciferous vegetables by adding some mustard powder (contains myrinase). Broccoli and edamame beans also contains small amounts of NMN. Wow, that's super interesting, thanks Fre...
by Fred
Mon Nov 11, 2019 4:42 pm
Forum: NMN
Topic: Table of the four ongoing NMN human clinical trials
Replies: 4
Views: 608

Re: Table of the four ongoing NMN human clinical trials

These are the hormones looked at in the unpublished 2017 24-week trial. The subjects were between 50-70 and the doses were 100 and 200 mg. According to a Japanese manufacturer, the trial revealed increased melatonin levels. I´m curious of the SIRT1 and 2 gene expression in leucocytes. "Effect of lon...