Search found 10 matches

by Youvion
Fri Sep 13, 2019 4:06 am
Forum: Longevity
Topic: NEW (10 sep) Two hour in-depth interview with professor David Sinclair on treating aging, NMN and cellular reprogramming
Replies: 7
Views: 1933

Re: NEW (10 sep) Two hour in-depth interview with professor David Sinclair on treating aging, NMN and cellular reprogram

There is a more informative/technical interview with David Sinclair by Peter Attia https://peterattiamd.com/davidsinclair2/ SIR genes and cellular identity [8:45]; Sirtuins regulate gene expression [14:30]; DNA is methylated at the deepest layer of the epigenome [17:45]; Methylation pattern and dete...
by Youvion
Thu Sep 12, 2019 1:30 am
Forum: Longevity
Topic: David Sinclair's New Book is OUT!!!
Replies: 7
Views: 1957

Re: David Sinclair's New Book is OUT!!!

Even better than the Joe Rogan podcast which is pretty high level, check out The Peter Attia Drive podcast #70 which does a much more deep dive into the methylation clock, the reprograming of cells back to more youthful methylation profiles and of course NAD's role in longevity. For those who want a...
by Youvion
Mon Sep 09, 2019 11:50 pm
Forum: Nutrition
Topic: Super aging mostly fraudulent? Time to re-evaluate "longevity diet"?
Replies: 12
Views: 4017

Re: Super aging mostly fraudulent? Time to re-evaluate "longevity diet"?

There was an interesting account of the twin astronauts, one who was on the space station for a year, and one that remained on earth. They found that the astronaut in space had significantly lengthened telomers upon return compared to his earth bound brother. BUT after a short time his telomers shru...
by Youvion
Mon Sep 09, 2019 11:36 pm
Forum: Longevity
Topic: Besides Dr. Sinclair - who else is leading the charge with anti-aging molecules?
Replies: 8
Views: 2669

Re: Besides Dr. Sinclair - who else is leading the charge with anti-aging molecules?

There are multitudes of other researchers looking at NAD+ elevation and its effects on aging. Below is just one recent review article written by authors from the Mayo Clinic College of Medicine entitled: NAD and the Aging Process: Role in Life, Death and Everything in Between https://www.ncbi.nlm.ni...
by Youvion
Tue Sep 03, 2019 7:51 am
Forum: Senolytics
Topic: How Genome Sequencing and Senolytics Can Help Us Live Healthier, Longer
Replies: 6
Views: 4322

Re: How Genome Sequencing and Senolytics Can Help Us Live Healthier, Longer

I think the general link between NAD+ increase through NMN precursors is that with higher NAD+ levels at the cellular level, the incidence of senescent cells will be less because the cells are functionally "younger" in their operation since NAD+ is such a fundamental chemical for many cell functions...
by Youvion
Tue Sep 03, 2019 7:28 am
Forum: NMN
Topic: Why do you take NMN?
Replies: 33
Views: 7430

Re: Why do you take NMN?

I started taking NR about 5 years ago after meeting David Sinclair and listening to him explain his research results. At that time, NMN was not commercially available (or if it was it was $1000+ per bottle) but switched over to NMN once AlivebyNature made the switch. I would say that the reason I am...
by Youvion
Tue Sep 03, 2019 7:13 am
Forum: Fasting
Topic: When Fasting Gets Tough, the Tough Immune Cells Get Going—or Die
Replies: 23
Views: 7405

Re: When Fasting Gets Tough, the Tough Immune Cells Get Going—or Die

Another approach, also pioneered by Longo is the Fasting Mimicing Diet (FMD). His research found that following a diet for 5 days that basically consists of 809 calories/day with Fat 46%, Carbohydrates 46% and Protein 9% produced significant upregulation of REgeneration markers. https://www.ncbi.nlm...
by Youvion
Tue Sep 03, 2019 6:58 am
Forum: Healthy Aging News and Research
Topic: Anyone is taking rapamycin or metformin?
Replies: 23
Views: 6488

Re: Anyone is taking rapamycin or metformin?

In Thailand you can buy Metformin over the counter, no questions asked. You can also buy a lot of other prescription drugs including antibiotics which some Thais pop like aspirin whenever they don't feel well leading to antibiotic resistance.
by Youvion
Tue Aug 27, 2019 4:22 am
Forum: NMN
Topic: NMN is apparently good for the liver
Replies: 3
Views: 2566

Re: NMN is apparently good for the liver

Here is some additional research on how NAD+ supplementation is good for the liver, specifically fatty liver disease. https://www.ncbi.nlm.nih.gov/pubmed/28254760 In this paper they describe a supplementation regiment that consists of NR (before the days of NMN being readily available) to up regulat...