Search found 72 matches

by p75213
Mon Mar 16, 2020 8:29 pm
Forum: Healthy Aging News and Research
Topic: The AMPK Sirt1 Cycle
Replies: 2
Views: 3902

Re: The AMPK Sirt1 Cycle

"AMPK can activate SIRT1 by increasing the NAD/NADH ratio or the expression/activity of NAMPT "

AMPK by itself will increase NAD+ levels. I wonder how much more? As much as a NAD+ precursor? Enough to reach a more youthful level?
by p75213
Fri Mar 13, 2020 2:16 pm
Forum: Miscellaneous Topics
Topic: Sirtuins Are Evolutionarily Conserved Viral Restriction Factors
Replies: 3
Views: 2902

Re: Sirtuins Are Evolutionarily Conserved Viral Restriction Factors

Are they're supplements available that activate all the sirtuins? Personally I'd like to employ all the help I can against cov-19.
by p75213
Thu Mar 12, 2020 6:27 pm
Forum: Healthy Aging News and Research
Topic: The AMPK Sirt1 Cycle
Replies: 2
Views: 3902

The AMPK Sirt1 Cycle

The takeaway: AMPK activates sirt1 and vice versa. Therefore if you take a supplement to activate one you are also indirectly activating the other. That's 2 for the price of one. Jiaogulan is one of the better researched AMPK activators and EVOO a powerfull activator of sirt1. Sirtuins are a group o...
by p75213
Tue Mar 10, 2020 5:50 pm
Forum: Senolytics
Topic: Mayo Clinic Human Trial using Fisetin
Replies: 45
Views: 29496

Re: Mayo Clinic Human Trial using Fisetin

The mayo protocol calls for 20mg per kg of fisetin over 2 days followed by the same dosage 1 month later. I'm wondering how long it takes for senescent cells to increase in numbers to where they need to be knocked out once again.
by p75213
Sat Mar 07, 2020 4:13 pm
Forum: Fasting
Topic: Effect of Fasting on Laryngopharyngeal Reflux Disease in Male Subjects
Replies: 8
Views: 6749

Re: Effect of Fasting on Laryngopharyngeal Reflux Disease in Male Subjects

My stomach has issues with both green and black tea. Also coffee.
by p75213
Fri Mar 06, 2020 7:33 pm
Forum: Longevity
Topic: Taurine Activates Sirt1 and increases NAD+/NADH Ratio
Replies: 2
Views: 3887

Re: Taurine Activates Sirt1 and increases NAD+/NADH Ratio

As we age the amount of taurine produced by the body declimes.
by p75213
Fri Mar 06, 2020 5:14 am
Forum: Longevity
Topic: Taurine Activates Sirt1 and increases NAD+/NADH Ratio
Replies: 2
Views: 3887

Taurine Activates Sirt1 and increases NAD+/NADH Ratio

Less expensive than both resveritrol and olive oil (and easier on the stomach). Not sure on the comparative effectiveness though. "Meanwhile, taurine increased NAD+/NADH ratio,promoted the expression of SIRT1 and suppressed p53 acetylation." https://pubmed.ncbi.nlm.nih.gov/32017914-taurine-protects-...
by p75213
Wed Feb 19, 2020 12:47 am
Forum: Longevity
Topic: Potential of Theaflavin 3-Gallate in black tea in anti-aging!
Replies: 10
Views: 2143

Re: Potential of Theaflavin 3-Gallate in black tea in anti-aging!

Seems theaflavin 3-gallate is not available as a standalone supplement.
by p75213
Wed Feb 12, 2020 5:45 pm
Forum: Fasting
Topic: Effect of Fasting on Laryngopharyngeal Reflux Disease in Male Subjects
Replies: 8
Views: 6749

Re: Effect of Fasting on Laryngopharyngeal Reflux Disease in Male Subjects

As somebody who suffers with gerd, my anecdotal experience with fasting is it made it worse. In particular an increase in having to swallow due to a lump in my throat. Not too much of a problem during the day. However it interferes with sleep during the night.
by p75213
Tue Feb 11, 2020 4:58 pm
Forum: Fasting
Topic: Effect of Fasting on Laryngopharyngeal Reflux Disease in Male Subjects
Replies: 8
Views: 6749

Effect of Fasting on Laryngopharyngeal Reflux Disease in Male Subjects

Abstract To address the effect of fasting on laryngopharyngeal reflux disease (LPRD). A total of 22 male subjects have been recruited for this study. Subjects with vocal fold pathologies, recent history of upper respiratory tract infection or laryngeal manipulation were excluded. Demographic data in...