Search found 108 matches

by rhett
Mon Feb 17, 2020 3:18 pm
Forum: NMN
Topic: Small dose of NMN restores fertility in old mice, large dose does not – implications for dosage suggestions
Replies: 8
Views: 571

Re: Small dose of NMN restores fertility in old mice, large dose does not – implications for dosage suggestions

Actually... I think I got that wrong with the 2g/L conversion. It should be closer to 1500mg.

So 350mg is the lower dose and 1500mg is the higher dose
by rhett
Mon Feb 17, 2020 12:38 pm
Forum: NAD+
Topic: NAD+ Too Big to Enter Cell?
Replies: 24
Views: 517

Re: NAD+ Too Big to Enter Cell?

Thanks 🙏 that makes a lot of sense. It’s very cool to see this field developing so quickly.
by rhett
Sun Feb 16, 2020 4:43 pm
Forum: NAD+
Topic: NAD+ Too Big to Enter Cell?
Replies: 24
Views: 517

Re: NAD+ Too Big to Enter Cell?

I will just admit that I'm completely confused. Why did the precursors even get developed if straight NAD+ worked all along?
by rhett
Sun Feb 16, 2020 11:39 am
Forum: NMN
Topic: Small dose of NMN restores fertility in old mice, large dose does not – implications for dosage suggestions
Replies: 8
Views: 571

Re: Small dose of NMN restores fertility in old mice, large dose does not – implications for dosage suggestions

If you do an allometric conversion of the doses in the study. The dose that increased fertility would be around 350mg for a human. And the dose that seemed to be too high would be around 1800mg for a human.
by rhett
Thu Feb 13, 2020 12:16 pm
Forum: NMN
Topic: fertility can be restored by NMN treatment in aged mice
Replies: 3
Views: 194

Re: fertility can be restored by NMN treatment in aged mice

Super interesting is that in the study, the lower dose (.5g/L) worked while the higher dose (1g/L) did nothing, maybe even hindered a little. They mention that maybe there is a point where too much NMN is metabolizing into regular nicotinamide which is a SIRT inhibitor. Worth taking into considerati...
by rhett
Sat Feb 08, 2020 5:39 pm
Forum: Miscellaneous Topics
Topic: Researchers Find Cell-Free Mitochondria Floating in Human Blood
Replies: 3
Views: 186

Re: Researchers Find Cell-Free Mitochondria Floating in Human Blood

Of all the fascinating things about the human body, mitochondria just blow my mind. The idea that entirely separate organisms with their own DNA that somehow got incorporated into larger organisms and are now an integral part of our existence. And now we find that they don't just power cells, but so...
by rhett
Sat Feb 08, 2020 5:34 pm
Forum: Nutrition
Topic: Quality Resveratrol
Replies: 5
Views: 203

Re: Quality Resveratrol

Thank you Fred, that looks like a great source. I might give them a try.
by rhett
Sat Feb 08, 2020 5:30 pm
Forum: Senolytics
Topic: Interesting chart of sensescent cells by age
Replies: 14
Views: 444

Interesting chart of sensescent cells by age

Came across this chart on twitter showing accumulation of senescent cells by age: https://twitter.com/Mangan150/status/1226139912145010690 The black line is human mortality, the red line is senescent cell accumulation. A few super interesting things: 1. They match almost exactly 2. From data start a...
by rhett
Fri Feb 07, 2020 7:30 pm
Forum: Nutrition
Topic: Quality Resveratrol
Replies: 5
Views: 203

Re: Quality Resveratrol

Same question here. I'm taking Jarrow Pterostilbene at the moment but I'm thinking about just going full on 100% David Sinclair protocol and not try to make up my own combos.
by rhett
Thu Feb 06, 2020 1:09 am
Forum: NMN
Topic: Stop NMN before surgery?
Replies: 7
Views: 270

Re: Stop NMN before surgery?

I'm curious if others will have more detailed information, but if they say stop all supplements for 2 weeks, then I'd include NMN in that. We are still early days with NMN and I'm not sure anyone can say with certainty that it's ok. Maybe one day we'll know enough to have a confident answer to that ...