Search found 31 matches

by nettlesbe
Fri Nov 15, 2019 8:27 am
Forum: FAQs
Topic: Testing
Replies: 2
Views: 3855

Re: Testing

Each product page has the test certificate posted just below the product image and short description.
by nettlesbe
Thu Nov 14, 2019 7:45 pm
Forum: NMN
Topic: The magic 500mg threshold :)
Replies: 50
Views: 8832

Re: The magic 500mg threshold :)

I have also found NAD+ before bed helps me sleep better. In particular, I get more deep sleep, according to my oura ring. Dr Matthew Walker shares fascinating info on sleep - how important it is for health, and how to improve it. As important as exercise and diet. Really spurred me to focus on that....
by nettlesbe
Thu Sep 26, 2019 12:50 pm
Forum: NAD+
Topic: NAD+ Nasal Spray Dosage
Replies: 28
Views: 5312

Re: NAD+ Nasal Spray Dosage

A couple of studies that demostrate high bioavailability of intranasal NAD+. Even better than IV for reaching brain... Prevention of Traumatic Brain Injury-Induced Neuron Death by Intranasal Delivery of Nicotinamide Adenine Dinucleotide (won, 2012) The present study demonstrates that intranasally-ad...
by nettlesbe
Thu Sep 19, 2019 8:56 pm
Forum: NAD+
Topic: Nuchida Claim
Replies: 2
Views: 1307

Re: Nuchida Claim

You're right, NAD+ has been proven to enter some cells directly by Connexin43. Also some other routes. https://alivebynature.com/exogenous-nad-enters-hypothalamus-intact-decreases-hunger-and-increases-energy-expenditure/ The enzymes to metabolize it to NMN, NR, NAM and other products like very benef...
by nettlesbe
Sat Sep 14, 2019 7:52 pm
Forum: Longevity
Topic: Exactly Where is Sinclair on Rolling Back Age?
Replies: 13
Views: 4698

Re: Exactly Where is Sinclair on Rolling Back Age?

It is amazing. Reading the book gave me some background I didn't have before that makes it more believable. I used to think Dr Sinclair kind of "lucked" into his role with Resveratrol, somewhat like Dr Brenner did in discovering NR pathway to NAD+. But he actually had a major Eureka breakthrough at ...
by nettlesbe
Sat Sep 14, 2019 4:56 pm
Forum: NR
Topic: NAD+ precursor increases aerobic performance.
Replies: 3
Views: 979

Re: NAD+ precursor increases aerobic performance.

Thanks, but I'm not sure what you are referring to. They feed the mice 400mg/kg a day of NR for 5 weeks, which would be something like 2000 mg a day for a 70 kg human. Dr Brenners study gave humans 1000 mg a day NR for 3 weeks. Do you mean the different dosage, delivery method, or time length might ...
by nettlesbe
Sat Sep 14, 2019 1:58 pm
Forum: NR
Topic: NAD+ precursor increases aerobic performance.
Replies: 3
Views: 979

Re: NAD+ precursor increases aerobic performance.

These were YOUNG mice, which is likely why NR by itself did not help. Would really like to see if NR by itself increases endurance in older mice, like NMN does. Another thing that stands out to me is, NR increased NAD+ levels in the muscle. In the recent study by Dr Brenner , NR did NOT increase NAD...
by nettlesbe
Thu Sep 12, 2019 7:06 pm
Forum: NMN
Topic: Podcast by Dr Sinclair and Dr Mark Harmon - Sept 11, 2019
Replies: 0
Views: 942

Podcast by Dr Sinclair and Dr Mark Harmon - Sept 11, 2019

New podcast by Dr Sinclair and Dr Mark Harmon. Mostly rehash but a few interesting things I noticed: 33:30 Sinclair - there is a spike in 2-3 hours, then it goes back down (NAD+ levels from taking NMN) 34:30 Sinclair - Lenny just had a paper that came out yesterday that show parkinsons patient do b...
by nettlesbe
Thu Sep 12, 2019 6:22 pm
Forum: NAD+
Topic: NAD+ IV increases NAD+ levels in blood plasma 400% in humans
Replies: 12
Views: 3361

Re: NAD+ IV increases NAD+ levels in blood plasma 400% in humans

Sinclair has suggested that the microbiome in blood removes a lot of the nicotinamide from NMN and NR before it's taken up by the gut, so maybe some of this is true of NAD+ as well. The exact method is multi-pronged and "messy" according to him but maybe we're getting closer to finding the truth. Y...
by nettlesbe
Thu Sep 12, 2019 2:54 pm
Forum: NAD+
Topic: NAD+ IV increases NAD+ levels in blood plasma 400% in humans
Replies: 12
Views: 3361

Re: NAD+ IV increases NAD+ levels in blood plasma 400% in humans

Interesting. But how do we know the NAD+ isn't simply metabolized to something else in the first 2 hours? The authors propose 2 possibilities: Either NAD+ and/or the primary metabolites tested are being efficiently sequestered during this first 2–6 h period or secondary metabolites are also being f...