Search found 83 matches

by AlbertY
Tue Dec 31, 2019 8:13 am
Forum: Fasting
Topic: The Best intermittent fasting reviewing article
Replies: 3
Views: 1895

Re: The Best intermittent fasting reviewing article

Thank you AlbertY! Great paper. Reading it now with a hot mug of instant espresso (yes, instant coffee contains more beneficial polyphenols than fresh coffee. Instant is more concentrated in caffeic acid and chlorogenic acid for example). The neuroscientist Mark Mattsson, Dr Satchin Panda at the Sa...
by AlbertY
Fri Dec 27, 2019 12:44 am
Forum: Fasting
Topic: The Best intermittent fasting reviewing article
Replies: 3
Views: 1895

The Best intermittent fasting reviewing article

Hi everyone, I just want to share a recent review paper: Effects of Intermittent Fasting on Health, Aging, and Disease. I heard of this review from an aging conference at Harvard months ago, and it is finally online recently. I'm really excited to finally be able to read it and I have to say it is t...
by AlbertY
Wed Dec 25, 2019 4:34 pm
Forum: Fasting
Topic: Daily fasts:Best time of day
Replies: 13
Views: 2997

Re: Daily fasts:Best time of day

I am guessing that supper or later is the best time to fast - mostly as I imagine our metabolism is busiest in the evening. Is there data on this? Yes Similarly, metabolic markers were improved in a group of people eating an isocaloric diet with a bigger breakfast and a smaller dinner (52, 53), and...
by AlbertY
Fri Dec 20, 2019 4:47 pm
Forum: Healthy Aging News and Research
Topic: Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells.
Replies: 0
Views: 1538

Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells.

In this landmark study, the Robin Franklin group has addressed possible reasons for this failure to remyelinate. In contrast to the bulk of studies within the field that utilize OPCs isolated from young rodents, this study optimized protocols to isolate OPCs from either young adults (2-3 months) or ...
by AlbertY
Fri Dec 20, 2019 4:34 pm
Forum: NMN
Topic: Weight vs volume
Replies: 6
Views: 1933

Re: Weight vs volume

I think the 1/4 tsp of NMN is just approximately 1 gram right? You don't need to be super accurate here. And yes, other kinds of fat just works the same.
by AlbertY
Fri Dec 13, 2019 3:17 pm
Forum: NMN
Topic: NAD and the precursor NMN are degraded to NR in growth media before embryonic kidney cells import them
Replies: 13
Views: 3021

NAD and the precursor NMN are degraded to NR in growth media before embryonic kidney cells import them

When cultivated in serum-free medium, HEK293 cells efficiently cleaved NAD+ and NAAD to NMN and NAMN. NMN exhibited rather high stability in cell culture, but was partially metabolized to NR. Using pharmacological inhibitors of plasma membrane transporters, we also showed that extracellular cleavage...
by AlbertY
Sun Dec 08, 2019 1:27 pm
Forum: NAD+
Topic: New research shows that NAD+ supplementation can slow Wernersyndrome (a progeria disease) in mice
Replies: 1
Views: 567

New research shows that NAD+ supplementation can slow Wernersyndrome (a progeria disease) in mice

In a new study in the scientific journal Nature Communications, an international team of researchers from, among others, the University of Copenhagen and the National Institutes of Health in the United States, has come closer to a new way of attacking the disease. The researchers have looked at a cl...
by AlbertY
Mon Nov 25, 2019 7:46 pm
Forum: Longevity
Topic: Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial
Replies: 7
Views: 1344

Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial

This prospective, randomized, placebo-controlled, exploratory study was conducted to test the hypothesis that a topical application of rapamycin (10 μM) would decrease the number of senescent cells in the skin and decrease markers of aging. Thirty-six participants were enrolled in the study, and nin...
by AlbertY
Sun Nov 24, 2019 7:48 pm
Forum: Longevity
Topic: Unanswered Questions Remain from Sinclair's Recent Epigenetic Mouse Experiments
Replies: 10
Views: 1835

Re: Unanswered Questions Remain from Sinclair's Recent Epigenetic Mouse Experiments

In this article by Josh Mitteldorf, he claims there remain unanswered questions from Sinclair's recent Epigenetic mouse experiments and whether Sinclair has in fact told us everything. For example, in Sinclair's experiment to reset the mouse epigenome in the optic nerve, 3 of the 4 Yamanaka factors...
by AlbertY
Sun Nov 24, 2019 11:34 am
Forum: Longevity
Topic: mTOR inhibition Phase 3 clinical trial fails.
Replies: 2
Views: 638

mTOR inhibition Phase 3 clinical trial fails.

resTORbio Announces That the Phase 3 PROTECTOR 1 Trial of RTB101 in Clinically Symptomatic Respiratory Illness Did Not Meet the Primary Endpoint RTB101 were inhibiting mTORC1, to minimize side effects of whole TOR inhibition, and targeting respiratory illness. https://ir.restorbio.com/news-releases/...