Search found 82 matches

by AlbertY
Sat Nov 09, 2019 11:13 am
Forum: NAD+
Topic: link NAD+ to the ten hallmarks of brain aging
Replies: 1
Views: 1332

link NAD+ to the ten hallmarks of brain aging

Lautrup et al. link NAD+ to the ten hallmarks of brain aging, summarize the effects of NAD+ augmentation on brain disorders, and point to NAD+-based clinical trials and future perspectives. https://www.sciencedirect.com/science/article/abs/pii/S1550413119305029 NAD+ is a pivotal metabolite involved ...
by AlbertY
Sun Nov 03, 2019 5:21 pm
Forum: NMN
Topic: AMPK Activator
Replies: 7
Views: 2167

Re: AMPK Activator

Fisetin is also a senolytic drug, I don't think you should take it on a daily basis. Take it a few days each month instead, you can refer to joko's post for more information. viewtopic.php?t=699
by AlbertY
Thu Oct 31, 2019 7:02 pm
Forum: Healthy Aging News and Research
Topic: New insight into type 2 diabetes and hyperinsulinemia
Replies: 5
Views: 2573

New insight into type 2 diabetes and hyperinsulinemia

There is a recent paper shows that hyperinsulinemia (high blood insulin level) can cause cell senescence in the brain, which offers a direct connection between peripheral hyperinsulinemia, as found in prediabetes, age-related neurodegeneration and cognitive decline. https://www.nature.com/articles/s...
by AlbertY
Wed Oct 23, 2019 6:12 pm
Forum: Nutrition
Topic: A nutritional memory effect counteracts the benefits of dietary restriction in old age
Replies: 0
Views: 1633

A nutritional memory effect counteracts the benefits of dietary restriction in old age

Here, a group report results of a late-life DR-switch experiment using 800 mice. Female mice aged 24 months were switched from an ad libitum (AL) diet to dietary restriction (DR) or vice versa. Strikingly, the switch from DR to AL acutely increases mortality , whereas the switch from AL to DR causes...
by AlbertY
Mon Oct 21, 2019 1:20 pm
Forum: NMN
Topic: Important question regarding extended use of NMN or NR
Replies: 22
Views: 6684

Re: Important question regarding extended use of NMN or NR

These questions cannot be answered until large-scaled human trials have been done. But based on the current model of how NAD+ and sirtuin work, the answer to the first question is: unlikely. Based on the epigenetic theory of aging, aging is a result of the random events that happen after DNA damage...
by AlbertY
Thu Oct 17, 2019 3:58 pm
Forum: Exercise
Topic: A new study shows it's never too late to begin strength building
Replies: 8
Views: 3511

A new study shows it's never too late to begin strength building

It's never too late to adopt healthy habits! New research from the University of Birmingham shows that older adults in their seventies and eighties new to strength training have the same ability to build muscle as those who have been exercising for years: https://bigthink.com/surprising-science/stre...
by AlbertY
Wed Oct 16, 2019 12:28 pm
Forum: NMN
Topic: Important question regarding extended use of NMN or NR
Replies: 22
Views: 6684

Re: Important question regarding extended use of NMN or NR

These questions cannot be answered until large-scaled human trials have been done. But based on the current model of how NAD+ and sirtuin work, the answer to the first question is: unlikely. Based on the epigenetic theory of aging, aging is a result of the random events that happen after DNA damage ...
by AlbertY
Tue Oct 15, 2019 11:06 pm
Forum: Nutrition
Topic: Omega-3 fish oil supplements lower the risk of heart attack and CVD
Replies: 1
Views: 1881

Omega-3 fish oil supplements lower the risk of heart attack and CVD

People who received omega-3 fish oil supplements in randomized clinical trials had lower risks of heart attack and other cardiovascular disease (CVD) events than those who were given placebo, according to a new meta-analysis from Harvard T.H. Chan School of Public Health and Brigham and Women’s Hosp...
by AlbertY
Sun Oct 13, 2019 5:21 pm
Forum: Nutrition
Topic: The Sprinting Challenge.
Replies: 31
Views: 12175

Re: The Sprinting Challenge.

This is amazing! I'm wondering were you super strong at your 20s? There was a study shows that exercise, when you are young, can stimulate the division of the muscle cell nucleus. During aging, the potential of nucleus division decreased and one might also experience amyotrophy. However, the extra n...
by AlbertY
Sat Oct 12, 2019 3:40 pm
Forum: Other NAD+ Boosters
Topic: Roadmap to boosting cellular NAD+ with natural supplements: apigenin, quercetin, leucine etc (NAMPT, PARP1))
Replies: 22
Views: 10590

Re: Roadmap to boosting cellular NAD+ with natural supplements: apigenin, quercetin, leucine etc (NAMPT, PARP1))

Any experimenters out there? Shouldn't be too difficult to make up some powder using Nuchido's ingredients. One serving: 10 mg ascorbic acid 250 mg nicotinamide 300 mg alpha lipoic acid 5 mg zinc 1.1 g Propietary Blend green tea leaf extract (~500) parsley leaf powder (~400) rutin extract (~150) bl...