Search found 82 matches

by AlbertY
Sat Sep 28, 2019 11:10 am
Forum: Exercise
Topic: Clinical trial: Metformin blunts muscle hypertrophy in response to PRT training in older adults
Replies: 5
Views: 2464

Re: Clinical trial: Metformin blunts muscle hypertrophy in response to PRT training in older adults

I see people theorizing about alternating workouts and metformin, but I’m curious how much separation there needs to be between a metformin dose and a workout. The short answer is we don't know yet. But I think you should consider metformin as a mimetic of exercising, it mimics the benefit of exerc...
by AlbertY
Fri Sep 27, 2019 12:17 pm
Forum: Exercise
Topic: Clinical trial: Metformin blunts muscle hypertrophy in response to PRT training in older adults
Replies: 5
Views: 2464

Clinical trial: Metformin blunts muscle hypertrophy in response to PRT training in older adults

https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13039 These results underscore the benefits of PRT in older adults, but metformin negatively impacts the hypertrophic response to resistance training in healthy older individuals. Kind of confirmed that it is bad to combine metformin and exercise
by AlbertY
Fri Sep 20, 2019 10:44 pm
Forum: Exercise
Topic: Exercising While Restricting Calories Could be Bad for Bone Health
Replies: 17
Views: 4635

Exercising While Restricting Calories Could be Bad for Bone Health

Exercise and caloricrestriction are both associated with + health outcomes in mice, but when added together seem to be negative for bone health http://news.unchealthcare.org/news/2019/september/exercising-while-restricting-calories-could-be-bad-for-bone-health Also, it is also bad taking metformin w...
by AlbertY
Wed Sep 18, 2019 5:14 pm
Forum: Senolytics
Topic: Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin
Replies: 1
Views: 1145

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin

Findings D + Q reduced adipose tissue senescent cell burden within 11 days, with decreases in p16INK4A-and p21CIP1-expressing cells, cells with senescence-associated β-galactosidase activity, and adipocyte progenitors with limited replicative potential. Adipose tissue macrophages, which are attracte...
by AlbertY
Tue Sep 17, 2019 3:52 pm
Forum: NAD+
Topic: NAD+ Regeneration Rescues Lifespan in a Mouse Model of Brain Mitochondrial Disease
Replies: 4
Views: 1963

NAD+ Regeneration Rescues Lifespan in a Mouse Model of Brain Mitochondrial Disease

Seems that boosting NAD+ is beneficial to mitochondrial function even in mitochondrial disease. Maybe NMN or NR will become FDA-approved for mitochondrial diseases in the future.

https://papers.ssrn.com/sol3/papers.cfm ... VY.twitter
by AlbertY
Sun Sep 15, 2019 10:43 pm
Forum: Longevity
Topic: Exactly Where is Sinclair on Rolling Back Age?
Replies: 13
Views: 5787

Re: Exactly Where is Sinclair on Rolling Back Age?

I agree. OSK reprogramming is probably the most exciting breakthrough in the field of aging up to now. But they haven't observed the lifespan extension yet. Next step would be doing reprogramming on an accelerated-aging mouse model, the ICE mouse, to see how reprogramming can extend their lifespan. ...
by AlbertY
Sun Sep 15, 2019 10:38 pm
Forum: Exercise
Topic: Voluntary running can counteract aging!
Replies: 14
Views: 4183

Voluntary running can counteract aging!

Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice
https://onlinelibrary.wiley.com/doi/10. ... 8k.twitter
by AlbertY
Wed Sep 11, 2019 9:19 am
Forum: Other NAD+ Boosters
Topic: EGCG reduces stress and anxiety in new study
Replies: 10
Views: 4297

Re: EGCG reduces stress and anxiety in new study

Very interesting research. I'm also a big fan of green tea. Half of the dry weight of green tea is EGCG, so you always get enough amount.
by AlbertY
Tue Sep 10, 2019 4:04 pm
Forum: Longevity
Topic: NEW (Peter Attia) interview with Dr David Sinclair about longevity, how he takes NMN, sirtuins, metformin and resv
Replies: 17
Views: 4327

Re: NEW interview with Dr David Sinclair about longevity, how he takes NMN, sirtuins, metformin and resveratrol and more

Regarding Oral vs Sublingual use of NMN, Sinclair says there is good in both. m1:55 - No good answers on sublingual or not. Microbiome removes a lot of the nicotinomide from NMN and NR before it's taken up by the gut but it makes sense not to put it all through the gut. Some NMN does get through th...