NRNR and NR Chloride

p75213
Posts: 72
Joined: Wed Sep 11, 2019 12:04 am

NR and NR Chloride

Post by p75213 » Wed Oct 09, 2019 6:33 pm

In addition to nicotinamide riboside there is also nicotinamide riboside chloride. Which one does everyone take and why? Does it really matter?


Fred

Re: NR and NR Chloride

Post by Fred » Wed Oct 09, 2019 6:41 pm

The chloride salt is bound to NR to stabilise it. The tradename "Niagen" is the chloride form and was first to market.
p75213
Posts: 72
Joined: Wed Sep 11, 2019 12:04 am

Re: NR and NR Chloride

Post by p75213 » Thu Oct 10, 2019 12:46 am

So all the NR that is sold as a supplement is in fact NR chloride? Some brands don't specifically say niagen or NR chloride. Just NR.
Fred

Re: NR and NR Chloride

Post by Fred » Thu Oct 10, 2019 1:27 am

Elysium used Niagen from the beginning. Now the source or form of NR in Elysium's Basis is unknown. True Niagen, Thorne and LEF use Niagen.
ChrisBON
Posts: 40
Joined: Mon Sep 16, 2019 6:09 pm

Re: NR and NR Chloride

Post by ChrisBON » Thu Oct 24, 2019 5:17 pm

Fred wrote:
Thu Oct 10, 2019 1:27 am
Elysium used Niagen from the beginning. Now the source or form of NR in Elysium's Basis is unknown. True Niagen, Thorne and LEF use Niagen.
So if i am taking NMN sl and NAD+ as well as Astaxanthin and Blueberry Concentrate, is NR really necessary?
Taking:
NMN since June, 2019 (started at 250mg, 500mg as of Oct 1st)
NAD+ nasal spray since July, 2019
Resveratrol since Sept 2019
Astaxanthin 10mg since October 20th
Blueberry concentrate 500 mg since October 20th
Berberine 250 mg since October 20th
Fred

Re: NR and NR Chloride

Post by Fred » Thu Oct 24, 2019 5:53 pm

The difference in pharmacokinetics and target tissues between NR and NMN in humans is currently unknown (we have to wait for human NMN data to be published).

They are similar molecules. NMN is NR with a phosphate group attached (which makes it more stable in solution). NR converts to NMN inside the cell and NMN can convert to NR outside the cell. Both have produced positive effects in animal trials.

There have been no published animal experiments using the two together so we don't know if there's any synergistic effect.
Last edited by Fred on Sat Oct 26, 2019 5:05 am, edited 2 times in total.
Vandevalk1
Posts: 268
Joined: Wed Aug 21, 2019 6:33 pm
Location: Port Elgin, ON, Canada

Re: NR and NR Chloride

Post by Vandevalk1 » Fri Oct 25, 2019 9:49 am

Thanks Fred. Very interesting!
ChrisBON
Posts: 40
Joined: Mon Sep 16, 2019 6:09 pm

Re: NR and NR Chloride

Post by ChrisBON » Sat Oct 26, 2019 3:49 pm

Thanks Fred
I appreciate it!
Taking:
NMN since June, 2019 (started at 250mg, 500mg as of Oct 1st)
NAD+ nasal spray since July, 2019
Resveratrol since Sept 2019
Astaxanthin 10mg since October 20th
Blueberry concentrate 500 mg since October 20th
Berberine 250 mg since October 20th
canadahealthy
Posts: 167
Joined: Tue Aug 20, 2019 5:31 pm

Re: NR and NR Chloride

Post by canadahealthy » Sun Oct 27, 2019 2:08 pm

ChrisBON wrote:
Thu Oct 24, 2019 5:17 pm
Fred wrote:
Thu Oct 10, 2019 1:27 am
Elysium used Niagen from the beginning. Now the source or form of NR in Elysium's Basis is unknown. True Niagen, Thorne and LEF use Niagen.
So if i am taking NMN sl and NAD+ as well as Astaxanthin and Blueberry Concentrate, is NR really necessary?
i think NR is another way of elevating NAD+ and there is some arguing as to whether it is as effective or even more effective than NMN. However, the leading researcher, Dr David Sinclair, insists NMN is the most reliable method.

I think with all you are taking that you do not need NR.
smokinjoe
Posts: 64
Joined: Sun Sep 01, 2019 9:24 am

Re: NR and NR Chloride

Post by smokinjoe » Thu Oct 31, 2019 4:42 pm

canadahealthy wrote:
Sun Oct 27, 2019 2:08 pm
ChrisBON wrote:
Thu Oct 24, 2019 5:17 pm
Fred wrote:
Thu Oct 10, 2019 1:27 am
Elysium used Niagen from the beginning. Now the source or form of NR in Elysium's Basis is unknown. True Niagen, Thorne and LEF use Niagen.
So if i am taking NMN sl and NAD+ as well as Astaxanthin and Blueberry Concentrate, is NR really necessary?
i think NR is another way of elevating NAD+ and there is some arguing as to whether it is as effective or even more effective than NMN. However, the leading researcher, Dr David Sinclair, insists NMN is the most reliable method.

I think with all you are taking that you do not need NR.
I think ChrisBON is taking the stuff I need to take.
Male, 41
no i don't smoke :)

taking:
NAD+ nasal since August 15, 2019
NMN powder, 125 mg per day; 625 per day since Oct 1, 2019
Resveratrol 600mg, since September 15, 2019
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