Page 1 of 2

organ scar tissue - general discussion

Posted: Wed Jan 29, 2020 9:31 pm
by canadahealthy
i am thinking of two organs that suffer scar tissue with grave results: kidneys and liver.

has scar tissue ever been a target of NAD+ studies? How about other Sirtuins?

Re: organ scar tissue - general discussion

Posted: Thu Jan 30, 2020 7:10 am
by Drdavid
Here is a couple of articles that I think you will find interesting regarding skin and scars.

Skin pharmacology and physiology
Sirtuins in Skin and Skin Cancers
Liz Mariely Garcia-Peterson, Melissa Jean Wilking-Busch, [...], and Nihal Ahmad
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568696/


Bai XZ, Liu JQ, Yang LL, et al. Identification of sirtuin 1 as a promising therapeutic target for hypertrophic scars. Br J Pharmacol. 2016;173(10):1589–1601. doi:10.1111/bph.13460
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842923/

Re: organ scar tissue - general discussion

Posted: Fri Jan 31, 2020 9:12 am
by AlbertY
By scaring you mean fibrosis? If so, the senolytic drugs are the thing you should look at (I'm not sure whether NAD+ precursor helps but senolytics are proved to be able to treat fibrosis.)

Re: organ scar tissue - general discussion

Posted: Fri Jan 31, 2020 2:51 pm
by canadahealthy
AlbertY wrote:
Fri Jan 31, 2020 9:12 am
By scaring you mean fibrosis? If so, the senolytic drugs are the thing you should look at (I'm not sure whether NAD+ precursor helps but senolytics are proved to be able to treat fibrosis.)
I admit i get them confused. Can you give me a list of proven senolytic drugs?

Re: organ scar tissue - general discussion

Posted: Fri Jan 31, 2020 3:50 pm
by AlbertY
canadahealthy wrote:
Fri Jan 31, 2020 2:51 pm
AlbertY wrote:
Fri Jan 31, 2020 9:12 am
By scaring you mean fibrosis? If so, the senolytic drugs are the thing you should look at (I'm not sure whether NAD+ precursor helps but senolytics are proved to be able to treat fibrosis.)
I admit i get them confused. Can you give me a list of proven senolytic drugs?
Fisetin is the most promising one among those commercially available senolytic drugs. You can refer to Joko's post for more information
viewtopic.php?f=45&t=699

Re: organ scar tissue - general discussion

Posted: Sun Feb 02, 2020 9:43 pm
by canadahealthy
AlbertY wrote:
Fri Jan 31, 2020 3:50 pm
canadahealthy wrote:
Fri Jan 31, 2020 2:51 pm
AlbertY wrote:
Fri Jan 31, 2020 9:12 am
By scaring you mean fibrosis? If so, the senolytic drugs are the thing you should look at (I'm not sure whether NAD+ precursor helps but senolytics are proved to be able to treat fibrosis.)
I admit i get them confused. Can you give me a list of proven senolytic drugs?
Fisetin is the most promising one among those commercially available senolytic drugs. You can refer to Joko's post for more information
viewtopic.php?f=45&t=699
Also, if one can do a 5 day fast... autophagy and stem cell generation are possibilities.

viewtopic.php?f=77&t=1120&p=2750&hilit=rapamycin#p2750

Re: organ scar tissue - general discussion

Posted: Mon Feb 03, 2020 7:08 am
by Drdavid
Excellent recommendation

Re: organ scar tissue - general discussion

Posted: Wed Feb 05, 2020 5:16 am
by Paulapea
Hello
I was given the book lifespan for Christmas and I'm fasinanated by all this.
Please bare with me I've never used s forum before.
Can I ask a Q
I hope it makes sense.
Does NMN increase NAD there for boosting ATP?
So there for do I need to just take NMN
Rather than both NMN and NAD?
Thank you

Re: organ scar tissue - general discussion

Posted: Wed Feb 05, 2020 5:43 pm
by Newage
Paulapea wrote:
Wed Feb 05, 2020 5:16 am
Hello
I was given the book lifespan for Christmas and I'm fasinanated by all this.
Please bare with me I've never used s forum before.
Can I ask a Q
I hope it makes sense.
Does NMN increase NAD there for boosting ATP?
So there for do I need to just take NMN
Rather than both NMN and NAD?
Thank you
Welcome to the forum Paulapea.
Some of the forum members take only NMN as the precursor to elevating NAD+ levels and there are some of us that take both molecules as they seem to work differently within the body.
You could start with NMN and the NAD+ Nasal Spray which is a good combination.
Remember to start with a lower dose and progressively build from there.
A low daily dosage would be seen as 250 mg NMN
( 2 tablets) and 50mg of NAD+ Nasal Spray.
The Nasal Spray seems to give you the near immediate effect of enhanced clarity..

Re: organ scar tissue - general discussion

Posted: Thu Feb 06, 2020 6:57 am
by Drdavid
Paulapea wrote:
Wed Feb 05, 2020 5:16 am
Hello
I was given the book lifespan for Christmas and I'm fasinanated by all this.
Please bare with me I've never used s forum before.
Can I ask a Q
I hope it makes sense.
Does NMN increase NAD there for boosting ATP?
So there for do I need to just take NMN
Rather than both NMN and NAD?
Thank you
Welcome to the forum. You are always welcome to ask and answer questions. Many of us take both NMN and NAD+ because they seem to provide different benefits in the short term.