Other NAD+ BoostersRoadmap to boosting cellular NAD+ with natural supplements: apigenin, quercetin, leucine etc (NAMPT, PARP1))

Fred
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Roadmap to boosting cellular NAD+ with natural supplements: apigenin, quercetin, leucine etc (NAMPT, PARP1))

Post by Fred » Thu Aug 15, 2019 8:59 am

My proposal of a theoretical natural supplement that boosts cellular NAD+ synthesis by NAMPT activation and PARP inhibition without NR, NAR, NMN, NAM, NA or l-tryptophan. What would you add?


1. Troxerutin
2. Grape-seed proanthocyanidins
3. Leucine
4. Apigenin
5. Quercetin

(and I would perhaps add 1 g resveratrol in the morning)


NAD+ biosynthesis augmentation by NAMPT activation and PARP inhibition


1. Troxerutin

A trihydroxyethylated derivative of the natural bioflavonoid rutin, markedly increased NAD+ levels and potentiated SIRT1 via NAMPT activation and PARP1 inhibition in HFD-treated mouse liver.

“Troxerutin improves hepatic lipid homeostasis by restoring NAD(+)-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice.”
https://www.ncbi.nlm.nih.gov/pubmed/25026599/


2. Grape-seed PACs (proanthocyanidins)
PACs significantly increased the hepatic NAD+ content by modulating the hepatic concentrations of the major NAD+ precursors as well as the mRNA levels of the genes that encode the enzymes involved in the cellular metabolism of NAD+. Sirtuin 1 (Sirt1) gene expression was also significantly up-regulated in a dose-response pattern.

“Dietary proanthocyanidins boost hepatic NAD(+) metabolism and SIRT1 expression and activity in a dose-dependent manner in healthy rats.”
https://www.nature.com/articles/srep24977

“Dietary proanthocyanidins modulate BMAL1 acetylation, Nampt expression and NAD levels in rat liver”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603780/



AMPK activators

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity.
https://www.ncbi.nlm.nih.gov/pubmed/19262508/


3. Leucine
Addition of leucine to high fat diet correlated with increased expression of SIRT1 and NAMPT (nicotinamide phosphoribosyltransferase) as well as higher intracellular NAD(+) levels.

"Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice."
https://www.ncbi.nlm.nih.gov/pubmed/22967499/



Decrease NAD+ catabolism

CD38 inhibition


4. Apigenin
“Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome.”
https://www.ncbi.nlm.nih.gov/pubmed/23172919/

“Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609577/


5. Quercetin
Blocking CD38 with quercetin could significantly relieve kidney dysfunction, kidney pathological changes as well as inflammatory cell accumulation.

“Blockade of CD38 diminishes lipopolysaccharide-induced macrophage classical activation and acute kidney injury involving NF-κB signaling suppression.”
https://www.ncbi.nlm.nih.gov/pubmed/29080804


PARP inhibition
Troxerutin and proanthocyanidins also inhibit PARPs in mice, thereby contributing to increased NAD+ in tissues.


p75213
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Re: Roadmap to boosting cellular NAD+ with natural supplements: apigenin, quercetin, leucine etc (NAMPT, PARP1))

Post by p75213 » Thu Sep 26, 2019 4:08 pm

It will be interesting to see what's in the Nuchido Time+ product when it's finally released.
Fred
Posts: 433
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Location: Sweden

Re: Roadmap to boosting cellular NAD+ with natural supplements: apigenin, quercetin, leucine etc (NAMPT, PARP1))

Post by Fred » Fri Sep 27, 2019 6:29 am

Nuchido stated that the product contains 3 mg of caffeine so a decaffeinated green tea extract with EGCG as a NAMPT up regulator is probable.

Nuchido´s patent lists a NAD+ precursor in the salvage pathway like nicotinamide or nicotinic acid in combination with a myriad of possible polyphenols like quercetin, curcumin, apigenin, resveratrol but also alpha-lipoic acid. We´ll see when they disclose the ingredients list.
Fred
Registered dietitian, Sweden.
Vandevalk1
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Location: Port Elgin, ON, Canada

Re: Roadmap to boosting cellular NAD+ with natural supplements: apigenin, quercetin, leucine etc (NAMPT, PARP1))

Post by Vandevalk1 » Fri Sep 27, 2019 12:08 pm

is this a new product the ABN is coming out with?
Fred
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Location: Sweden

Re: Roadmap to boosting cellular NAD+ with natural supplements: apigenin, quercetin, leucine etc (NAMPT, PARP1))

Post by Fred » Fri Sep 27, 2019 2:37 pm

Vandevalk1 wrote:
Fri Sep 27, 2019 12:08 pm
is this a new product the ABN is coming out with?
No.
Fred
Registered dietitian, Sweden.
p75213
Posts: 72
Joined: Wed Sep 11, 2019 12:04 am

Re: Roadmap to boosting cellular NAD+ with natural supplements: apigenin, quercetin, leucine etc (NAMPT, PARP1))

Post by p75213 » Tue Oct 08, 2019 3:27 pm

Fred wrote:
Fri Sep 27, 2019 6:29 am
Nuchido stated that the product contains 3 mg of caffeine so a decaffeinated green tea extract with EGCG as a NAMPT up regulator is probable.

Nuchido´s patent lists a NAD+ precursor in the salvage pathway like nicotinamide or nicotinic acid in combination with a myriad of possible polyphenols like quercetin, curcumin, apigenin, resveratrol but also alpha-lipoic acid. We´ll see when they disclose the ingredients list.
https://i.imgur.com/OuPzALd.jpg
Fred
Posts: 433
Joined: Tue Aug 13, 2019 3:17 pm
Location: Sweden

Re: Roadmap to boosting cellular NAD+ with natural supplements: apigenin, quercetin, leucine etc (NAMPT, PARP1))

Post by Fred » Tue Oct 08, 2019 3:53 pm

Thank you p75213 for providing the ingredients list.
Fred
Registered dietitian, Sweden.
p75213
Posts: 72
Joined: Wed Sep 11, 2019 12:04 am

Re: Roadmap to boosting cellular NAD+ with natural supplements: apigenin, quercetin, leucine etc (NAMPT, PARP1))

Post by p75213 » Fri Oct 11, 2019 3:19 pm

Any experimenters out there? Shouldn't be too difficult to make up some powder using Nuchido's ingredients.

One serving:

10 mg ascorbic acid
250 mg nicotinamide
300 mg alpha lipoic acid
5 mg zinc

1.1 g Propietary Blend
green tea leaf extract (~500)
parsley leaf powder (~400)
rutin extract (~150)
black pepper fruit extract (~50)
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AlbertY
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Re: Roadmap to boosting cellular NAD+ with natural supplements: apigenin, quercetin, leucine etc (NAMPT, PARP1))

Post by AlbertY » Sat Oct 12, 2019 3:40 pm

p75213 wrote:
Fri Oct 11, 2019 3:19 pm
Any experimenters out there? Shouldn't be too difficult to make up some powder using Nuchido's ingredients.

One serving:

10 mg ascorbic acid
250 mg nicotinamide
300 mg alpha lipoic acid
5 mg zinc

1.1 g Propietary Blend
green tea leaf extract (~500)
parsley leaf powder (~400)
rutin extract (~150)
black pepper fruit extract (~50)
On their website, they claimed "Trial results show that on average, this increase is 4 times more than precursor-based supplements such as NR and NMN." But I didn't find any trial result, anyone knows where did they publish it?
Ph.D. student at Harvard Medical School, doing research on aging
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