Other NAD+ Boostersorgan scar tissue - general discussion

canadahealthy
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organ scar tissue - general discussion

Post by canadahealthy » Wed Jan 29, 2020 9:31 pm

i am thinking of two organs that suffer scar tissue with grave results: kidneys and liver.

has scar tissue ever been a target of NAD+ studies? How about other Sirtuins?


Drdavid
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Re: organ scar tissue - general discussion

Post by Drdavid » Thu Jan 30, 2020 7:10 am

Here is a couple of articles that I think you will find interesting regarding skin and scars.

Skin pharmacology and physiology
Sirtuins in Skin and Skin Cancers
Liz Mariely Garcia-Peterson, Melissa Jean Wilking-Busch, [...], and Nihal Ahmad
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568696/


Bai XZ, Liu JQ, Yang LL, et al. Identification of sirtuin 1 as a promising therapeutic target for hypertrophic scars. Br J Pharmacol. 2016;173(10):1589–1601. doi:10.1111/bph.13460
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842923/
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AlbertY
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Location: Boston, MA

Re: organ scar tissue - general discussion

Post by AlbertY » Fri Jan 31, 2020 9:12 am

By scaring you mean fibrosis? If so, the senolytic drugs are the thing you should look at (I'm not sure whether NAD+ precursor helps but senolytics are proved to be able to treat fibrosis.)
Ph.D. student at Harvard Medical School, doing research on aging
canadahealthy
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Re: organ scar tissue - general discussion

Post by canadahealthy » Fri Jan 31, 2020 2:51 pm

AlbertY wrote:
Fri Jan 31, 2020 9:12 am
By scaring you mean fibrosis? If so, the senolytic drugs are the thing you should look at (I'm not sure whether NAD+ precursor helps but senolytics are proved to be able to treat fibrosis.)
I admit i get them confused. Can you give me a list of proven senolytic drugs?
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AlbertY
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Re: organ scar tissue - general discussion

Post by AlbertY » Fri Jan 31, 2020 3:50 pm

canadahealthy wrote:
Fri Jan 31, 2020 2:51 pm
AlbertY wrote:
Fri Jan 31, 2020 9:12 am
By scaring you mean fibrosis? If so, the senolytic drugs are the thing you should look at (I'm not sure whether NAD+ precursor helps but senolytics are proved to be able to treat fibrosis.)
I admit i get them confused. Can you give me a list of proven senolytic drugs?
Fisetin is the most promising one among those commercially available senolytic drugs. You can refer to Joko's post for more information
viewtopic.php?f=45&t=699
Ph.D. student at Harvard Medical School, doing research on aging
canadahealthy
Posts: 178
Joined: Tue Aug 20, 2019 5:31 pm

Re: organ scar tissue - general discussion

Post by canadahealthy » Sun Feb 02, 2020 9:43 pm

AlbertY wrote:
Fri Jan 31, 2020 3:50 pm
canadahealthy wrote:
Fri Jan 31, 2020 2:51 pm
AlbertY wrote:
Fri Jan 31, 2020 9:12 am
By scaring you mean fibrosis? If so, the senolytic drugs are the thing you should look at (I'm not sure whether NAD+ precursor helps but senolytics are proved to be able to treat fibrosis.)
I admit i get them confused. Can you give me a list of proven senolytic drugs?
Fisetin is the most promising one among those commercially available senolytic drugs. You can refer to Joko's post for more information
viewtopic.php?f=45&t=699
Also, if one can do a 5 day fast... autophagy and stem cell generation are possibilities.

viewtopic.php?f=77&t=1120&p=2750&hilit=rapamycin#p2750
Drdavid
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Re: organ scar tissue - general discussion

Post by Drdavid » Mon Feb 03, 2020 7:08 am

Excellent recommendation
Paulapea
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Re: organ scar tissue - general discussion

Post by Paulapea » Wed Feb 05, 2020 5:16 am

Hello
I was given the book lifespan for Christmas and I'm fasinanated by all this.
Please bare with me I've never used s forum before.
Can I ask a Q
I hope it makes sense.
Does NMN increase NAD there for boosting ATP?
So there for do I need to just take NMN
Rather than both NMN and NAD?
Thank you
Newage
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Joined: Thu Aug 22, 2019 10:22 pm

Re: organ scar tissue - general discussion

Post by Newage » Wed Feb 05, 2020 5:43 pm

Paulapea wrote:
Wed Feb 05, 2020 5:16 am
Hello
I was given the book lifespan for Christmas and I'm fasinanated by all this.
Please bare with me I've never used s forum before.
Can I ask a Q
I hope it makes sense.
Does NMN increase NAD there for boosting ATP?
So there for do I need to just take NMN
Rather than both NMN and NAD?
Thank you
Welcome to the forum Paulapea.
Some of the forum members take only NMN as the precursor to elevating NAD+ levels and there are some of us that take both molecules as they seem to work differently within the body.
You could start with NMN and the NAD+ Nasal Spray which is a good combination.
Remember to start with a lower dose and progressively build from there.
A low daily dosage would be seen as 250 mg NMN
( 2 tablets) and 50mg of NAD+ Nasal Spray.
The Nasal Spray seems to give you the near immediate effect of enhanced clarity..
Drdavid
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Joined: Thu Aug 15, 2019 9:59 am

Re: organ scar tissue - general discussion

Post by Drdavid » Thu Feb 06, 2020 6:57 am

Paulapea wrote:
Wed Feb 05, 2020 5:16 am
Hello
I was given the book lifespan for Christmas and I'm fasinanated by all this.
Please bare with me I've never used s forum before.
Can I ask a Q
I hope it makes sense.
Does NMN increase NAD there for boosting ATP?
So there for do I need to just take NMN
Rather than both NMN and NAD?
Thank you
Welcome to the forum. You are always welcome to ask and answer questions. Many of us take both NMN and NAD+ because they seem to provide different benefits in the short term.
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