NAD+NAD+ Nasal Spray Dosage

guest2701
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NAD+ Nasal Spray Dosage

Post by guest2701 » Tue Jul 23, 2019 11:06 pm

So for someone with no neurological issues age 55 what would be the recommended dosage of NAD nasal spray per day?


guest1576
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Re: NAD+ Nasal Spray Dosage

Post by guest1576 » Tue Jul 23, 2019 11:22 pm

Studies in mice show nasal spray is at least 10x more available than capsules. For a general rule, you can say 100 mg a day is a good target. That would be 2 sprays, 4 times a day. We have had several people try 500 mg a day for weeks, with no noticable problems, but can't recommend that high of dose. Best bet is to start at 100 mg a day and increase from there.
vandan
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Re: NAD+ Nasal Spray Dosage

Post by vandan » Mon Sep 16, 2019 11:33 pm

So does this make the NAD+ spray a more cost effective product?
canadahealthy
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Re: NAD+ Nasal Spray Dosage

Post by canadahealthy » Tue Sep 17, 2019 11:48 am

vandan wrote:
Mon Sep 16, 2019 11:33 pm
So does this make the NAD+ spray a more cost effective product?
I think it is a more immediate way of boosting NAD+ ; getting your levels up NOW, whereas NMN feeds the machine to keep them up on a day to day basis.
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jocko6889
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Re: NAD+ Nasal Spray Dosage

Post by jocko6889 » Tue Sep 17, 2019 11:54 am

I agree you get a more immediate boost from the NAD+ nasal spray. I take it right after my morning dose of NMN and the morning fog is lifted.
drkris69
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Re: NAD+ Nasal Spray Dosage

Post by drkris69 » Sat Sep 21, 2019 2:21 pm

Hey guys has anyone here tried the new product Cenergy yet? I just got a bottle and been on it now for 2 days. So far so good other than alittle discomfort if you do more than 2 sprays per nostril. I will keep you posted on results noted.
Drdavid
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Re: NAD+ Nasal Spray Dosage

Post by Drdavid » Sun Sep 22, 2019 8:50 pm

Dr. Kris, please keep us informed about the results.
vandan
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Re: NAD+ Nasal Spray Dosage

Post by vandan » Wed Sep 25, 2019 10:32 pm

guest1576 wrote:
Tue Jul 23, 2019 11:22 pm
Studies in mice show nasal spray is at least 10x more available than capsules. For a general rule, you can say 100 mg a day is a good target. That would be 2 sprays, 4 times a day. We have had several people try 500 mg a day for weeks, with no noticable problems, but can't recommend that high of dose. Best bet is to start at 100 mg a day and increase from there.
My wife who is an ENT surgeon tells me the steroidal nasal sprays have very low systemic conversion (i.e. 1%). Does anyone know why NMN would be any different? Is it the molecule size? Dr David?
Newage
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Re: NAD+ Nasal Spray Dosage

Post by Newage » Thu Sep 26, 2019 5:28 am

Vandan.
I am including NAD+ Nasal Spray into my regime in about 2 weeks so I will be posting very soon after that on what I believe will be significant increased benefits. I’m also looking forward to the instantaneous results after administering the spray.. in conjunction with the NMN..stay tuned
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nettlesbe
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Re: NAD+ Nasal Spray Dosage

Post by nettlesbe » Thu Sep 26, 2019 12:50 pm

A couple of studies that demostrate high bioavailability of intranasal NAD+. Even better than IV for reaching brain...



Prevention of Traumatic Brain Injury-Induced Neuron Death by Intranasal Delivery of Nicotinamide Adenine Dinucleotide (won, 2012)


The present study demonstrates that intranasally-administered NAD+ increases hippocampal NAD+ levels and reduces TBI-induced neuronal death in the hippocampus.

Intraperitoneal injection of the same NAD+ concentration that we used for intranasal administration showed no neuroprotective effects on TBI-induced neuronal death.

Compared with NAD+-treated rats, nicotinamide treatment showed no protective effects against TBI-induced neuronal death



Intranasal administration with NAD+ profoundly decreases brain injury in a rat model of transient focal ischemia (ying, 2007)

Increasing evidence has supported the hypothesis that PARP-1 induces cell death by depleting intracellular NAD+. We observed that intranasal NAD+ delivery significantly increased NAD+ contents in the brains. Intranasal delivery with 10 mg / kg NAD+ at 2 hours after ischemic onset profoundly decreased infarct formation when assessed either at 24 or 72 hours after ischemia. The NAD+ administration also significantly attenuated ischemia-induced neurological deficits. In contrast, intranasal administration with 10 mg / kg nicotinamide did not decrease ischemic brain damage. These results provide the first in vivo evidence that NAD+ metabolism is a new target for treating brain ischemia, and that NAD+ administration may be a novel strategy for decreasing brain damage in cerebral ischemia and possibly other PARP-1-associated neurological diseases.


Our results provide the first in vivo evidence that NAD+ administration can profoundly decrease brain damage under certain pathological conditions. It is noteworthy that NAD+ can reduce infarct formation by up to 86 % even when administered at 2 hrs after ischemic onset. Compared with other studies that apply drugs during post-ischemia phases in order for decreasing ischemic brain injury, the protective effect of NAD+ could be one of the most profound effects ever reported. In this study we also provided evidence that by the intranasal delivery approach NAD+ can be delivered into the brains.

Multiple studies have suggested that nicotinamide can decease ischemic brain injury, but at doses higher than 125 mg / kg (19). Our study shows that intranasal administration with nicotinamide at 10 mg / kg can not affect ischemic brain damage, in contrast to the profound protective effects of 10 mg / kg NAD+.
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