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link NAD+ to the ten hallmarks of brain aging

Posted: Sat Nov 09, 2019 11:13 am
by AlbertY
Lautrup et al. link NAD+ to the ten hallmarks of brain aging, summarize the effects of NAD+ augmentation on brain disorders, and point to NAD+-based clinical trials and future perspectives.

https://www.sciencedirect.com/science/a ... 3119305029

NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging findings that reveal key roles for NAD+ and related metabolites in the adaptation of neurons to a wide range of physiological stressors and in counteracting processes in neurodegenerative diseases, such as those occurring in Alzheimer’s, Parkinson’s, and Huntington diseases, and amyotrophic lateral sclerosis. Advances in understanding the molecular and cellular mechanisms of NAD+-based neuronal resilience will lead to novel approaches for facilitating healthy brain aging and for the treatment of a range of neurological disorders.

Re: link NAD+ to the ten hallmarks of brain aging

Posted: Tue Nov 26, 2019 7:24 am
by Drdavid
AlbertY wrote:
Sat Nov 09, 2019 11:13 am
Lautrup et al. link NAD+ to the ten hallmarks of brain aging, summarize the effects of NAD+ augmentation on brain disorders, and point to NAD+-based clinical trials and future perspectives.

https://www.sciencedirect.com/science/a ... 3119305029

NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging findings that reveal key roles for NAD+ and related metabolites in the adaptation of neurons to a wide range of physiological stressors and in counteracting processes in neurodegenerative diseases, such as those occurring in Alzheimer’s, Parkinson’s, and Huntington diseases, and amyotrophic lateral sclerosis. Advances in understanding the molecular and cellular mechanisms of NAD+-based neuronal resilience will lead to novel approaches for facilitating healthy brain aging and for the treatment of a range of neurological disorders.
Albert I always look forward to your posts. Thank you for your contributions.

Here is an article that I think you might like if you havent read it already
IUBMB Life. 2019 May; 71(5): 565–579.
Published online 2019 Jan 9. doi: 10.1002/iub.1997
PMCID: PMC6850382
PMID: 30624851
The “great” controlling nucleotide coenzymes
Richard L. Veech,corresponding author 1 Michael Todd King, 1 Robert Pawlosky, 1 Yoshihiro Kashiwaya, 2 Patrick C. Bradshaw, 3 and William Curtis 3
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850382/