NAD+Coronavirus infection dysregulate the NAD Metabolome

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AlbertY
Posts: 153
Joined: Mon Aug 12, 2019 4:01 pm
Location: Boston, MA

Coronavirus infection dysregulate the NAD Metabolome

Post by AlbertY » Sun Jul 12, 2020 2:31 pm

Here is a new study by Charles Brenner.

In short, Coronavirus infection will deplete cellular NAD, and NR supplementation ameliorate that.
Here we show that SARS-CoV-2 infection strikingly dysregulates the set of genes involved in consumption and biosynthesis of nicotinamide adenine dinucleotide (NAD). Highly induced genes include those encoding noncanonical poly(ADP-ribose) polymerase (PARP) family members known to function as mono ADP-ribosyltransferases but not known to deplete cellular NAD and genes encoding enzymes for salvage NAD synthesis from nicotinamide (NAM) and nicotinamide riboside (NR). We demonstrate that overexpression of PARP10 is sufficient to depress NAD levels and that the enzymatic activities of PARP10, PARP12 and PARP14 are limited by and can be enhanced by pharmacological activation of NAM salvage. We further showed that infection with the β-coronavirus murine hepatitis virus (MHV) induces a severe attack on host cell NAD+ and NADP+. Finally we show that NAMPT activation, NAM and NR dramatically decrease replication in a MHV infection model that is sensitive to PARP activity. The data show that the antiviral activities of noncanonical PARP isozyme activities are limited by their own consumption of cellular NAD and that nutritional and pharmacological interventions to enhance NAD-based defenses may boost innate immunity.
https://www.biorxiv.org/content/10.1101 ... 7.047480v5


Ph.D. student at Harvard Medical School, doing research on aging
Drdavid
Posts: 711
Joined: Thu Aug 15, 2019 9:59 am

Re: Coronavirus infection dysregulate the NAD Metabolome

Post by Drdavid » Sun Jul 12, 2020 6:20 pm

This is very interesting to see in print. We saw the effects of NAD+ on the front line workers and knew clinically that it worked. Now this shows some research behind it. I do find it interesting that PARP10 is involved.
NewLifeScience
Posts: 259
Joined: Thu Aug 22, 2019 4:17 pm

Re: Coronavirus infection dysregulate the NAD Metabolome

Post by NewLifeScience » Tue Jul 14, 2020 5:05 pm

I dunno...

If you get it. Of course you want to be at maximum levels of your health kit.

But we want either a vaccine or a plasma treatment.
Taking:
Resveratrol 400mg since June 2019; 600mg since October 1; 800mg since January 2020
NMN Sublingual 250mg since june 2019 500mg since September 2019
NAD+ Nasal, appx 100mg per day since September 2019; 200mg per day beginning mid November
Newage
Posts: 831
Joined: Thu Aug 22, 2019 10:22 pm

Re: Coronavirus infection dysregulate the NAD Metabolome

Post by Newage » Fri Jul 17, 2020 6:06 pm

Drdavid wrote:
Sun Jul 12, 2020 6:20 pm
This is very interesting to see in print. We saw the effects of NAD+ on the front line workers and knew clinically that it worked. Now this shows some research behind it. I do find it interesting that PARP10 is involved.
I will certainly be keeping my own levels of NAD+ at a premium level with heightened diligence during these unsettling times.
drkris69
Posts: 573
Joined: Tue Aug 20, 2019 2:41 pm

Re: Coronavirus infection dysregulate the NAD Metabolome

Post by drkris69 » Thu Jul 23, 2020 11:42 am

Great article and one that I will be showing patients why in these times they need to keep their NAD levels up. Thanks..
Newage
Posts: 831
Joined: Thu Aug 22, 2019 10:22 pm

Re: Coronavirus infection dysregulate the NAD Metabolome

Post by Newage » Thu Jul 23, 2020 3:10 pm

drkris69 wrote:
Thu Jul 23, 2020 11:42 am
Great article and one that I will be showing patients why in these times they need to keep their NAD levels up. Thanks..
It seems that NAD+ is becoming in its own right a form of an “adaptogen” that may help us deal with physical and mental stressors.
drkris69
Posts: 573
Joined: Tue Aug 20, 2019 2:41 pm

Re: Coronavirus infection dysregulate the NAD Metabolome

Post by drkris69 » Fri Jul 24, 2020 5:22 pm

Its certainly becoming the "go to" in the vitamin box when you're out of sorts.
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