NAD+NAD+ and Alzheimer’s Disease

Drdavid
Posts: 104
Joined: Thu Aug 15, 2019 9:59 am

NAD+ and Alzheimer’s Disease

Post by Drdavid » Fri Aug 23, 2019 9:49 am

NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency
Yujun Hou, Sofie Lautrup, Stephanie Cordonnier, Yue Wang, Deborah L. Croteau, Eduardo Zavala, Yongqing Zhang, Kanako Moritoh, Jennifer F. O’Connell, Beverly A. Baptiste, Tinna V. Stevnsner, Mark P. Mattson, and Vilhelm A. Bohr
PNAS February 20, 2018 115 (8) E1876-E1885; first published February 5, 2018 https://doi.org/10.1073/pnas.1718819115

Could mice with Alzheimer’s disease introduced DNA repair deficiency, signs of neuroinflammation, decreased synaptic transmission and phosphorylated Tau pathologies improve with supplementation of Nicotinamide Riboside? The researchers saw that by supplementing with Nicotinamide Riboside there was a decrease in neuroinflammation, improved synaptic transmission and normalized DNA damage. The mice that were supplemented with Nicotinamide Riboside also showed improved memory, learning and motor function. These findings led the researchers to believe that NAD+ supplementation has therapeutic implications for humans with Alzheimer’s disease.

This article can be seen herehttps://www.pnas.org/content/115/8/E1876.short


p75213
Posts: 1
Joined: Wed Sep 11, 2019 12:04 am

Re: NAD+ and Alzheimer’s Disease

Post by p75213 » Wed Sep 11, 2019 12:09 am

What would be the most effective NAD+ supplement for treating alzheimer's - sublingual powder/tablets or nasal spray?
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