Page 1 of 2

Interesting chart of sensescent cells by age

Posted: Sat Feb 08, 2020 5:30 pm
by rhett
Came across this chart on twitter showing accumulation of senescent cells by age:

https://twitter.com/Mangan150/status/12 ... 2145010690

The black line is human mortality, the red line is senescent cell accumulation. A few super interesting things:

1. They match almost exactly
2. From data start at 20 years to about 40 years, senescent cell levels seem relatively flat. Then levels begin a a fairly dramatic rise that continues until data end.

This suggests to me a good rationale for starting senolytics (and maybe even weekly rapamycin) around age 40.

Re: Interesting chart of sensescent cells by age

Posted: Wed Feb 12, 2020 6:54 am
by Drdavid
Thanks for the chart. I had not seen this before but you are correct that there seems to be a parallel. Senolytics may offer an answer

Re: Interesting chart of sensescent cells by age

Posted: Wed Feb 12, 2020 8:30 am
by drkris69
Yes very cool. :)

Re: Interesting chart of sensescent cells by age

Posted: Wed Feb 12, 2020 9:10 am
by drkris69
And for those that don't know what senolytics are here's an article.


https://www.lifespan.io/news/senolytics

Re: Interesting chart of sensescent cells by age

Posted: Wed Feb 12, 2020 12:38 pm
by Newage
drkris69 wrote:
Wed Feb 12, 2020 9:10 am
And for those that don't know what senolytics are here's an article.


https://www.lifespan.io/news/senolytics
Thanks drkris69
The more information, the better on this interesting subject..

Re: Interesting chart of sensescent cells by age

Posted: Wed Feb 12, 2020 1:42 pm
by drkris69
How you doing newage? Life back to normal??

Re: Interesting chart of sensescent cells by age

Posted: Wed Feb 12, 2020 5:26 pm
by NewLifeScience
rhett wrote:
Sat Feb 08, 2020 5:30 pm
Came across this chart on twitter showing accumulation of senescent cells by age:

https://twitter.com/Mangan150/status/12 ... 2145010690

The black line is human mortality, the red line is senescent cell accumulation. A few super interesting things:

1. They match almost exactly
2. From data start at 20 years to about 40 years, senescent cell levels seem relatively flat. Then levels begin a a fairly dramatic rise that continues until data end.

This suggests to me a good rationale for starting senolytics (and maybe even weekly rapamycin) around age 40.
So basically as soon as the average human stops having children.

I have known about extremely large families where the mother had children into her forties and lived into their late 90s

Re: Interesting chart of sensescent cells by age

Posted: Wed Feb 12, 2020 7:00 pm
by Newage
drkris69 wrote:
Wed Feb 12, 2020 1:42 pm
How you doing newage? Life back to normal??
Pretty much drkris69, thank you.
Still a way to go with summer and the fire season though..
“What doesn’t kill you toughens you up”
Can be a harsh country at times..

Re: Interesting chart of sensescent cells by age

Posted: Thu Feb 13, 2020 7:52 am
by drkris69
Yes sir I agree. Glad to hear that and keep on truckin on!

Re: Interesting chart of sensescent cells by age

Posted: Fri Feb 14, 2020 10:54 pm
by OzSport
Interesting graph, thanks rhett!