ExerciseClinical trial: Metformin blunts muscle hypertrophy in response to PRT training in older adults

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AlbertY
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Clinical trial: Metformin blunts muscle hypertrophy in response to PRT training in older adults

Post by AlbertY » Fri Sep 27, 2019 12:17 pm

https://onlinelibrary.wiley.com/doi/ful ... acel.13039

These results underscore the benefits of PRT in older adults, but metformin negatively impacts the hypertrophic response to resistance training in healthy older individuals.

Kind of confirmed that it is bad to combine metformin and exercise


Ph.D. student at Harvard Medical School, doing research on aging
Vandevalk1
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Re: Clinical trial: Metformin blunts muscle hypertrophy in response to PRT training in older adults

Post by Vandevalk1 » Fri Sep 27, 2019 12:37 pm

Very Interesting and a good read. I was proposing a pitch to my GP to prescribe me metformin but I am heavy into PRT and see this as a detriment now according to this study. I believe the best approach is keep my blood sugar levels low with diet for now.

thanks!
rhett
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Re: Clinical trial: Metformin blunts muscle hypertrophy in response to PRT training in older adults

Post by rhett » Fri Sep 27, 2019 11:22 pm

I see people theorizing about alternating workouts and metformin, but I’m curious how much separation there needs to be between a metformin dose and a workout.
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AlbertY
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Re: Clinical trial: Metformin blunts muscle hypertrophy in response to PRT training in older adults

Post by AlbertY » Sat Sep 28, 2019 11:10 am

rhett wrote:
Fri Sep 27, 2019 11:22 pm
I see people theorizing about alternating workouts and metformin, but I’m curious how much separation there needs to be between a metformin dose and a workout.
The short answer is we don't know yet. But I think you should consider metformin as a mimetic of exercising, it mimics the benefit of exercise through activating AMPK and cheating your body that you are short of energy. If you can exercise intensively every day, you can not benefit much from it and you don't actually need it. If you are obese and sedentary, you might need it and take it when you are not able to exercise.

But don't intentionally stop exercising just for taking metformin. Exercise is better, metformin is just a weaker mimetic with side effects.
Ph.D. student at Harvard Medical School, doing research on aging
Vandevalk1
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Re: Clinical trial: Metformin blunts muscle hypertrophy in response to PRT training in older adults

Post by Vandevalk1 » Mon Sep 30, 2019 6:05 pm

There is also a landslide of other benefits that come with PRT than just muscle hypertrophy.
PRT is clearly the the better choice of the two if possible.
CeeJayBee
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Re: Clinical trial: Metformin blunts muscle hypertrophy in response to PRT training in older adults

Post by CeeJayBee » Thu Oct 17, 2019 7:12 pm

AlbertY wrote:
Fri Sep 27, 2019 12:17 pm
https://onlinelibrary.wiley.com/doi/ful ... acel.13039

These results underscore the benefits of PRT in older adults, but metformin negatively impacts the hypertrophic response to resistance training in healthy older individuals.

Kind of confirmed that it is bad to combine metformin and exercise
I wonder how many of the participants have been adding B12 supplements to their diet
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