These approaches have in common the ability to downregulate evolutionarily conserved pathways implicated in growth and cell division, including the IGF1 and mTOR pathways, and modulate stem cell activation (Fontana et al., 2010)"
https://sci-hub.tw/https://www.scienced ... 7419308529
"Mammals evolved in the face of fluctuating food availability. How the immune system adapts to transient nutritional stress remains poorly understood. Here, we show that memory T cells collapsed in secondary lymphoid organs in the context of dietary restriction (DR) but dramatically accumulated within the bone marrow (BM), where they adopted a state associated with energy conservation.
This response was coordinated by glucocorticoids and associated with a profound remodeling of the BM compartment, which included an increase in T cell homing factors, erythropoiesis, and adipogenesis. Adipocytes, as well as CXCR4-CXCL12 and S1P-S1P1R interactions, contributed to enhanced T cell accumulation in BM during DR. Memory T cell homing to BM during DR was associated with enhanced protection against infections and tumors. Together, this work uncovers a fundamental host strategy to sustain and optimize immunological memory during nutritional challenges that involved a temporal and spatial reorganization of the memory pool within ‘‘safe haven’’ compartments.
I sleep like a rock with out waking up.
My body mass index went down even though I stayed the same weight; I've lost about 10 lbs of fat and gained muscle mass ( and I wasn't even trying to lose weight) This is obviously in conjunction with a steady workout plan.
my mental clarity is through the roof from where it was. (I'd be in a fog most days, especially in the morning and after work) This is likely related to the better sleep cycles I have now.
I also use to get heartburn and acid reflux where I do not anymore. Acid reflux is common in people who eat before bed. When your body is supposed to be resting during sleep so you can properly recharge, your body is working and breaking down foods using our stomach acid. gravity keeps acid down but when laying down during sleep, acid can creep into the esophagus. repeated exposure is linked to esophageal cancer.
My window is 16 hours fasting ( 7pm to 11am) leaving 8 hours available for eating. Restricted calorie intake in the 8 hours will further strip weight significantly.
You are spot on with the reflux issue.
The problem is solved by not eating after 7pm...or earlier if possible.
Also a teaspoon building up to a desert spoon of organic apple cider vinegar in water with your last meal of the day is also very beneficial to solving reflux and aiding sleep. I use Braggs Apple Cider Vinegar as a trusted brand..
My current fasting window is 6PM-8AM as I start craving food earlier and after my workout. and I have no urge to snack late. (lucky me)
It is also rumoured that breaking your fasting regiment one day a week is not the end of the world either. People have noted little to no adverse effects and still maintain all the benefits when the regiment is broken every now and again. (after all, we still need to enjoy ourselves)
Although it looks like a high Carbohydrate diet, but when we are only talking 809 calories (he does allow a bit more on day 1 - 1152 calories) you are not getting very much carbs anyway.
I find that if I go strict keto for a week, then transition to this diet for 5 days I can also easily transition into water fasting for a subsequent 3+ days. An approach for those who are a bit intimidated by the thought of no food at all.