NMNDoes the Sublingual NMN interrupt fasting?

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Re: Does the Sublingual NMN interrupt fasting?

Post by Vandevalk1 » Tue Nov 12, 2019 8:00 am

Telluride wrote:
Sat Nov 09, 2019 11:13 am
Vandevalk1 wrote:
Thu Nov 07, 2019 8:56 am
I try to stay away from all foods and drinks during my fasting. Regardless if it’s a pill or vitamin I swallow. Some say black coffee is ok but I am still a little sceptical as the verdict is out in that one.
I’ll just share my little anecdote with you. I’m 47 I’ve been intermittently fasting for about eight years now. I have lost about 40 pounds since I turn 40. I just used fasting a an easy “trick” to just skip breakfast without being as hungry. It was so simple and That worked perfectly for a lot of years. I recently realized I was “technically” breaking my fast by taking vitamins and some BCAA in the morning before my gym time. (I always thought that the “fast” was simply not being “hungry“!)

So I guess what I’m trying to say is it depends on what you’re trying to do. If you’re not hungry, and you’re using fasting as a way to diet, then I would say it’s OK if it doesn’t make you hungry after you have your coffee or whatever it is you’re taking during your fast. (I found that anything more than about 80 cal, I would get super hungry within the hour)

Now, If you’re trying for autophagy, then you shouldn’t eat anything other than coffee or green tea with no additives. Coffee and green tea Are actually shown to help with Autophagy. (if you’re interested, Dr. Rhonda Patrick has done several podcasts covering this exact topic where she discusses coffee actually helping To promote autophagy.)
super cool Telluride! I'd appreciate it if you could post these podcasts. I take most of what Dr. Rhonda Patrick says as gospel as she is extremely educated, articulate and well spoken. She often starts off with a crazy fact that is hard to belief but then always has the science to back it up.

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Re: Does the Sublingual NMN interrupt fasting?

Post by vandan » Tue Nov 12, 2019 7:38 pm

daviddean wrote:
Thu Nov 07, 2019 7:00 am
Its not only an issue about “food’s calories” but also about “sweetness of foods”, that,due to the vagal nerve stimulation, activate insulin and blocks the state of fasting…
Quote from my book on Intermittent Fasting:
https://www.amazon.com/80-20-Pareto-Die ... 361&sr=8-1
“Carbonated beverages, even a fruit, a fruit juice or a simple sugar-free candy can activate it (due to the vagal insulin stimulation given by the sweet taste). This is the main reason why during the fasting phase you should refrain completely from foods and caloric drinks, otherwise the organism's processes of lipolysis and detoxification will be obstructed.”

“NO to snacks”

No type of snack is allowed, as the stimulation of insulin, even with a candy or chewing gum, even if unsweetened, through the mechanism of vagal stimulation induced by the sensation of sweet, blocks the production of glucagon and the use of fats for energy purposes. This is why the advice to have snacks between meals is, from the point of view of intermittent fasting, only a nutritional invention that always maintains the body and the metabolism in the phase of overfeeding.

Don’t forget: stimulating insulin during the day does not allow the body to access its fat reserves. If you understand this well you will realize the importance of not having foods and drinks that are not allowed during the fasting window, and thus preventing its beneficial effects.

In my opinion, every tablet should be no only "sugar free", but alwso without any artificial sweeteners, so this will not interfere and block the fasting state for those who follow this diet regimen.
David De Angelis
That begs the question of how many years gained on average for these protocols? I am tempted to fast a little but not sure if its the recipe the fullest life. Perhaps we need another tablet for that...

Re: Does the Sublingual NMN interrupt fasting?

Post by Fred » Sat Nov 16, 2019 2:06 am

Sublingual NMN will not interrupt fasting.

You get autophagy turned on and IGF-1 plummets by keeping protein under 15 g a day and total kcal below 11 kcal per kg bw.

Since taking a high dose of NAD precursors signals energy intake (we get NR/NMN/NAD from food that is being partly broken down to nicotinamide and ribose etc and rebuilt into NAD within cells) I would take the NMN with refeeding and not during the fasting period.

I asked Dr David Sinclair exactly this during a Q&A and he said what I suspected, that we probably should take NMN with refeeding and not during the fasting days.

If science shows that NAD precursors are extra beneficial during a fast then that prescription may change of course.
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Re: Does the Sublingual NMN interrupt fasting?

Post by Asclepius » Mon Nov 25, 2019 7:51 pm

That's awesome information to have Fred.

Thanks all who took the time to post up info, much appreciated :)
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