NMNThe first NMN study in humans is published

Fred
Posts: 220
Joined: Tue Aug 13, 2019 3:17 pm
Location: Stockholm, Sweden

The first NMN study in humans is published

Post by Fred » Thu Nov 07, 2019 11:57 pm

The single oral administration of NMN capsules in the doses
100, 250 and 500 mg in 10 healthy Japanese men was shown to be safe.

"Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men"

The administration of nicotinamide mononucleotide (NMN) has been shown to mitigate aging-related dysfunctions. However, the safety of NMN in humans have remained unclear.

We, therefore, conducted a clinical trial to investigate the safety of single NMN administration in 10 healthy men. A single-arm non-randomized intervention was conducted by single oral administration of 100, 250, and 500 mg NMN.

Clinical findings and parameters, and the pharmacokinetics of NMN metabolites were investigated for 5 h after each intervention. Ophthalmic examination and sleep quality assessment were also conducted before and after the intervention.

The single oral administrations of NMN did not cause any significant clinical symptoms or changes in heart rate, blood pressure, oxygen saturation, and body temperature.

Laboratory analysis results did not show significant changes, except for increases in serum bilirubin levels and decreases in serum creatinine, chloride, and blood glucose levels within the normal ranges, independent of the dose of NMN.

Results of ophthalmic examination and sleep quality score showed no differences before and after the intervention. Plasma concentrations of N-methyl-2-pyridone-5- carboxamide and N-methyl-4-pyridone-5-carboxamide were significantly increased dose-dependently by NMN administration.

The single oral administration of NMN was safe and effectively metabolized in healthy men without causing any significant deleterious effects. Thus, the oral administration of NMN was found to be feasible, implicating a potential therapeutic strategy to mitigate aging-related disorders in humans.

https://www.jstage.jst.go.jp/article/en ... f/-char/en
Last edited by Fred on Fri Nov 08, 2019 7:06 am, edited 5 times in total.


Fred
Registered dietitian, Sweden.
Newage
Posts: 425
Joined: Thu Aug 22, 2019 10:22 pm

Re: The first NMN safety study in humans is published

Post by Newage » Fri Nov 08, 2019 12:39 am

Good post Fred.
“On the ball”
Along with you, I think everyone has been waiting in anticipation for a human trial to be published in some shape or form.
A positive step in the right direction..”Onward we march in the quest for longevity” ... :idea:
Fred
Posts: 220
Joined: Tue Aug 13, 2019 3:17 pm
Location: Stockholm, Sweden

Re: The first NMN study in humans is published

Post by Fred » Fri Nov 08, 2019 3:13 am

Now we need some long-term safety and efficacy studies on oral NMN in humans, which will probably be published in 2020 I believe Sinclair said recently.

Next, we will get more exciting PK studies to see how and wherein the body NMN and NAD+ will appear. From the paper, under DISCUSSION:
Our next clinical study to evaluate plasma NMN levels and NAD + levels in peripheral blood mononuclear cells is now in progress. If possible, biopsy samples from tissues such as the adipose tissue and skeletal muscle need to be analyzed for tissue NMN and NAD + levels.
Fred
Registered dietitian, Sweden.
AUKC
Posts: 80
Joined: Tue Aug 20, 2019 8:05 pm

Re: The first NMN study in humans is published

Post by AUKC » Fri Nov 08, 2019 6:07 am

Also some high dose clinical studies!

A good read to start with though.
Current Dosages:
200mg Resveratrol
750mg NMN
1000mg L-Arginine
drkris69
Posts: 210
Joined: Tue Aug 20, 2019 2:41 pm

Re: The first NMN study in humans is published

Post by drkris69 » Fri Nov 08, 2019 6:22 am

Interesting for sure.....
NewLifeScience
Posts: 105
Joined: Thu Aug 22, 2019 4:17 pm

Re: The first NMN study in humans is published

Post by NewLifeScience » Fri Nov 08, 2019 9:25 am

Good, so we are already given strong indication that it is being absorbed and boosting NAD, which we all pretty much knew in the first place.
Taking:
Resveratrol 400mg since June 2019; 600mg since October 1
NMN Sublingual 250mg since june 2019 500mg since September 2019
NAD+ Nasal, appx 100mg per day since September 2019; 200mg per day beginning mid November
Fred
Posts: 220
Joined: Tue Aug 13, 2019 3:17 pm
Location: Stockholm, Sweden

Re: The first NMN study in humans is published

Post by Fred » Fri Nov 08, 2019 10:05 am

NewLifeScience wrote:
Fri Nov 08, 2019 9:25 am
Good, so we are already given strong indication that it is being absorbed and boosting NAD, which we all pretty much knew in the first place.
What do you mean by "boosting NAD"? There´s no indication of that in this paper. They didn't even look at NAD-levels.
Fred
Registered dietitian, Sweden.
NewLifeScience
Posts: 105
Joined: Thu Aug 22, 2019 4:17 pm

Re: The first NMN study in humans is published

Post by NewLifeScience » Fri Nov 08, 2019 12:07 pm

Fred wrote:
Fri Nov 08, 2019 10:05 am
NewLifeScience wrote:
Fri Nov 08, 2019 9:25 am
Good, so we are already given strong indication that it is being absorbed and boosting NAD, which we all pretty much knew in the first place.
What do you mean by "boosting NAD"? There´s no indication of that in this paper. They didn't even look at NAD-levels.
maybe i misread this section...
We showed that 2Py and 4Py levels significantly
increased and their incremental areas above the baseline
were increased in a dose-dependent manner. A previous
study reported that the incremental changes in NAD+
level were correlated with those in MNA and 2Py levels
in peripheral blood mononuclear cells in healthy subject
after the administration of NR [19]. The finding supports
the speculation that the administration of NMN increased
tissue NAD+
Taking:
Resveratrol 400mg since June 2019; 600mg since October 1
NMN Sublingual 250mg since june 2019 500mg since September 2019
NAD+ Nasal, appx 100mg per day since September 2019; 200mg per day beginning mid November
Fred
Posts: 220
Joined: Tue Aug 13, 2019 3:17 pm
Location: Stockholm, Sweden

Re: The first NMN study in humans is published

Post by Fred » Fri Nov 08, 2019 12:12 pm

NewLifeScience wrote:
Fri Nov 08, 2019 12:07 pm
Fred wrote:
Fri Nov 08, 2019 10:05 am
NewLifeScience wrote:
Fri Nov 08, 2019 9:25 am
Good, so we are already given strong indication that it is being absorbed and boosting NAD, which we all pretty much knew in the first place.
What do you mean by "boosting NAD"? There´s no indication of that in this paper. They didn't even look at NAD-levels.
maybe i misread this section...
We showed that 2Py and 4Py levels significantly
increased and their incremental areas above the baseline
were increased in a dose-dependent manner. A previous
study reported that the incremental changes in NAD+
level were correlated with those in MNA and 2Py levels
in peripheral blood mononuclear cells in healthy subject
after the administration of NR [19]. The finding supports
the speculation that the administration of NMN increased
tissue NAD+
Yes. They, unfortunately, chose not to measure NAD+. What they speculate happened is irrelevant when they didn´t care to actually measure NAD+.
Fred
Registered dietitian, Sweden.
NewLifeScience
Posts: 105
Joined: Thu Aug 22, 2019 4:17 pm

Re: The first NMN study in humans is published

Post by NewLifeScience » Fri Nov 08, 2019 12:23 pm

Fred wrote:
Fri Nov 08, 2019 12:12 pm
NewLifeScience wrote:
Fri Nov 08, 2019 12:07 pm
Fred wrote:
Fri Nov 08, 2019 10:05 am


What do you mean by "boosting NAD"? There´s no indication of that in this paper. They didn't even look at NAD-levels.
maybe i misread this section...
We showed that 2Py and 4Py levels significantly
increased and their incremental areas above the baseline
were increased in a dose-dependent manner. A previous
study reported that the incremental changes in NAD+
level were correlated with those in MNA and 2Py levels
in peripheral blood mononuclear cells in healthy subject
after the administration of NR [19]. The finding supports
the speculation that the administration of NMN increased
tissue NAD+
Yes. They, unfortunately, chose not to measure NAD+. What they speculate happened is irrelevant when they didn´t care to actually measure NAD+.
well you are down playing it a little more than they do in their conclusion Fred :)

you are saying they are speculating. THEY are saying their findings support the speculation.

This may be about semantics, but they are saying something more than you are.

Still, i am left wondering WHY they wouldn't take the added step of measuring NAD+ levels. I am taking NMN as opposed to NR for the s[ecific reason that it is supposed to do a better job of boosting NAD+ along with many of us.
Taking:
Resveratrol 400mg since June 2019; 600mg since October 1
NMN Sublingual 250mg since june 2019 500mg since September 2019
NAD+ Nasal, appx 100mg per day since September 2019; 200mg per day beginning mid November
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