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Swallowing NMN raises NAD levels in the blood of humans, says Sinclair

Posted: Wed Jan 15, 2020 1:42 pm
by Fred
Från David Sinclairs AMA on Reddit:
Hi David, do you think there is a significant difference in sublingual vs oral administration of NMN?
Loved the book, amazing stuff!


davidasinclair:

I've not seen a head-to-head comparison. Don't know if there's an advantage to one or another. We all need to be data-driven. Someone should publish a study if they've done one. I can tell you that oral NMN can raise NAD levels in the bloodstream of mice and people.
https://www.reddit.com/r/IAmA/comments/ ... netics_at/


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Re: Swallowing NMN raises NAD levels in the blood of humans, says Sinclair

Posted: Wed Jan 15, 2020 3:27 pm
by rhett
From what I can tell, the concern about oral and the push for sublingual is mostly based on hypotheticals, reading between the lines of various other studies, rather than direct observation of oral nmn not working.

Re: Swallowing NMN raises NAD levels in the blood of humans, says Sinclair

Posted: Wed Jan 15, 2020 8:05 pm
by ALIVEBYNATURE
Nothing new afaik. Dr Sinclair has long said he knows oral NMN raises NAD+ levels in humans.

He is not saying some % that makes it intact through GI tract. It could be 100% degraded to NAM and would still raise NAD+. I don't think so, but we don't know.

Rabinowitz study showed bot NMN and NR are significantly degraded in mice. NR studies in humans show similar.

We need to know how much NMN makes it past the liver without being degraded to NAM. Hopefully, they will soon publish results from metrobiotech studies that were finished over a year ago.

Study comparing oral NMN and NR vs sublingual NMN in process now. Researchers hope to have some preliminary numbers in 2 months.

Re: Swallowing NMN raises NAD levels in the blood of humans, says Sinclair

Posted: Wed Jan 15, 2020 9:58 pm
by Fred
ALIVEBYNATURE wrote:
Wed Jan 15, 2020 8:05 pm
We need to know how much NMN makes it past the liver without being degraded to NAM. Hopefully, they will soon publish results from metrobiotech studies that were finished over a year ago.

Study comparing oral NMN and NR vs sublingual NMN in process now. Researchers hope to have some preliminary numbers in 2 months.
Some preliminary data in 2 months sounds great! Are you sponsoring this study?

Re: Swallowing NMN raises NAD levels in the blood of humans, says Sinclair

Posted: Wed Jan 15, 2020 10:07 pm
by FitandHealthyinAZ
Thanx ABN team for the news with respect to current studies in the coming months.

As for Sublingual vs. Oral; I read an interesting item in a published article awhile back titled: SUBLINGUAL MUCOSA AS A ROUTE FOR SYSTEMIC DRUG DELIVERY. The big takeaway's are: A, drug delivery via the oral mucous membrane is considered to be a promising alternative to the oral route. B, the sublingual route is a useful when rapid onset of action is desired with better patient compliance than orally ingested tablets and C, the portion of drug absorbed through the sublingual blood vessels bypasses the hepatic first‐pass metabolic processes giving acceptable bioavailability.

The bottom line is: Peak blood levels of most products administered sublingually are achieved within 10‐15 minutes, which is generally much faster than when the same drugs are ingested orally. Sublingual absorption is efficient. The percent of each dose absorbed is generally higher than that achieved by means of oral ingestion. Just sayin'

https://bit.ly/2Rjq1v2

Re: Swallowing NMN raises NAD levels in the blood of humans, says Sinclair

Posted: Thu Jan 16, 2020 2:54 pm
by drkris69
Wow this is good to know thank you ABN. Look forward to reading the future studies.

Re: Swallowing NMN raises NAD levels in the blood of humans, says Sinclair

Posted: Thu Jan 16, 2020 6:23 pm
by Newage
ALIVEBYNATURE wrote:
Wed Jan 15, 2020 8:05 pm
Nothing new afaik. Dr Sinclair has long said he knows oral NMN raises NAD+ levels in humans.

He is not saying some % that makes it intact through GI tract. It could be 100% degraded to NAM and would still raise NAD+. I don't think so, but we don't know.

Rabinowitz study showed bot NMN and NR are significantly degraded in mice. NR studies in humans show similar.

We need to know how much NMN makes it past the liver without being degraded to NAM. Hopefully, they will soon publish results from metrobiotech studies that were finished over a year ago.

Study comparing oral NMN and NR vs sublingual NMN in process now. Researchers hope to have some preliminary numbers in 2 months.
Thank you ABN.
It should answer the question about absorption comparisons that seems to be on everyone’s lips.
(Pardon the Pun). :roll:

Re: Swallowing NMN raises NAD levels in the blood of humans, says Sinclair

Posted: Fri Jan 17, 2020 7:20 am
by Drdavid
Data will give us concrete evidence of how the sublingual route works. We know that taking NMN/NAD through the sublingual method has shown positive outcomes in thousands of people. However, having evidence allows us to make better clinical decisions in these murky waters.

Re: Swallowing NMN raises NAD levels in the blood of humans, says Sinclair

Posted: Sun Jan 19, 2020 8:39 pm
by canadahealthy
Drdavid wrote:
Fri Jan 17, 2020 7:20 am
Data will give us concrete evidence of how the sublingual route works. We know that taking NMN/NAD through the sublingual method has shown positive outcomes in thousands of people. However, having evidence allows us to make better clinical decisions in these murky waters.
I just takes lots and often :)