Declining NAD(P)H is associated with oocyte dysfunction during reproductive aging
Oocyte quality and fertility can be restored by NMN treatment in aged mice
Supplementation of embryo media with NMN improves developmental milestones
SIRT2 overexpression mimics benefits of NMN but is unlikely to mediate its effects
Treatment with the NAD+ metabolic precursor nicotinamide mononucleotide (NMN) rejuvenates oocyte quality in aged animals, leading to restoration in fertility, and this can be recapitulated by transgenic overexpression of the NAD+-dependent deacylase SIRT2, though deletion of this enzyme does not impair oocyte quality. These benefits of NMN extend to the developing embryo, where supplementation reverses the adverse effect of maternal age on developmental milestones. These findings suggest that late-life restoration of NAD+ levels represents an opportunity to rescue female reproductive function in mammals.
https://www.sciencedirect.com/science/a ... 4720300838
Worth taking into consideration here. Looks like more NMN is not always better, at least beyond some point.
Anecdotally, do you know of any menopausal or post menopausal human females who have taken the molecules and had their fertility restored or any that may have actually gone on to fall pregnant and have a successful live birth?