NMNfertility can be restored by NMN treatment in aged mice

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AlbertY
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Location: Boston, MA

fertility can be restored by NMN treatment in aged mice

Post by AlbertY » Tue Feb 11, 2020 11:55 am

New study on NMN

Highlights

Declining NAD(P)H is associated with oocyte dysfunction during reproductive aging


Oocyte quality and fertility can be restored by NMN treatment in aged mice


Supplementation of embryo media with NMN improves developmental milestones


SIRT2 overexpression mimics benefits of NMN but is unlikely to mediate its effects

Treatment with the NAD+ metabolic precursor nicotinamide mononucleotide (NMN) rejuvenates oocyte quality in aged animals, leading to restoration in fertility, and this can be recapitulated by transgenic overexpression of the NAD+-dependent deacylase SIRT2, though deletion of this enzyme does not impair oocyte quality. These benefits of NMN extend to the developing embryo, where supplementation reverses the adverse effect of maternal age on developmental milestones. These findings suggest that late-life restoration of NAD+ levels represents an opportunity to rescue female reproductive function in mammals.

https://www.sciencedirect.com/science/a ... 4720300838


Ph.D. student at Harvard Medical School, doing research on aging
drkris69
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Joined: Tue Aug 20, 2019 2:41 pm

Re: fertility can be restored by NMN treatment in aged mice

Post by drkris69 » Wed Feb 12, 2020 2:24 pm

Wow, cool study thanks for sharing.
rhett
Posts: 108
Joined: Wed Sep 18, 2019 1:39 pm

Re: fertility can be restored by NMN treatment in aged mice

Post by rhett » Thu Feb 13, 2020 12:16 pm

Super interesting is that in the study, the lower dose (.5g/L) worked while the higher dose (1g/L) did nothing, maybe even hindered a little. They mention that maybe there is a point where too much NMN is metabolizing into regular nicotinamide which is a SIRT inhibitor.

Worth taking into consideration here. Looks like more NMN is not always better, at least beyond some point.
AJayeJ
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Joined: Sat Feb 15, 2020 3:56 am

Re: fertility can be restored by NMN treatment in aged mice

Post by AJayeJ » Sat Feb 15, 2020 4:09 am

Thanks for sharing AlbertY!

Anecdotally, do you know of any menopausal or post menopausal human females who have taken the molecules and had their fertility restored or any that may have actually gone on to fall pregnant and have a successful live birth?
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