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NMN reduces metabolic impairment in male mice offspring to obese mothers

Posted: Sun Mar 29, 2020 11:26 pm
by Fred
Maternal obesity impacts offspring metabolism. We sought to boost mitochondrial energy metabolism using the nicotinamide adenine dinucleotide (NAD+) precursor nicotinamide mononucleotide (NMN) to treat metabolic impairment induced by maternal and long-term post weaning over-nutrition.


https://www.ncbi.nlm.nih.gov/pubmed/32218167

Re: NMN reduces metabolic impairment in male mice offspring to obese mothers

Posted: Sun Jun 07, 2020 9:07 pm
by canadahealthy
Fred wrote:
Sun Mar 29, 2020 11:26 pm
]Maternal obesity impacts offspring metabolism. We sought to boost mitochondrial energy metabolism using the nicotinamide adenine dinucleotide (NAD+) precursor nicotinamide mononucleotide (NMN) to treat metabolic impairment induced by maternal and long-term post weaning over-nutrition.


Overall this finding suggests short term administration of NMN could be a therapeutic approach for treating metabolic disease due to maternal and post weaning over-nutrition, even in late adulthood
Well i hope what's good for mice is good for humans. Working in late adulthood suggests that NMN simply directs the metabolism to behave properly.

Re: NMN reduces metabolic impairment in male mice offspring to obese mothers

Posted: Thu Jun 25, 2020 7:45 pm
by ChrisBON
Fred wrote:
Sun Mar 29, 2020 11:26 pm
Maternal obesity impacts offspring metabolism. We sought to boost mitochondrial energy metabolism using the nicotinamide adenine dinucleotide (NAD+) precursor nicotinamide mononucleotide (NMN) to treat metabolic impairment induced by maternal and long-term post weaning over-nutrition.


https://www.ncbi.nlm.nih.gov/pubmed/32218167
I like this study, it hints that generational problems can be addressed or perhaps even corrected with NMN. Obesity related metabolism can run rampant in families, it would be nice if this could be corrected at the cellular level.