NMNUse bacteria to produce NMN

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AlbertY
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Location: Boston, MA

Use bacteria to produce NMN

Post by AlbertY » Thu Jul 30, 2020 3:23 pm

This is an interesting study https://pubmed.ncbi.nlm.nih.gov/32718347/

They engineered Escherichia coli cells to biosynthesize the NMN, which has been efficiently used in cell-free biosynthesis. They explored various pathway combinations and host gene disruption to achieve an intracellular level of ~ 1.5 mM NMN+, a 130-fold increase over the cell's basal level, in the best strain, which features a previously uncharacterized nicotinamide phosphoribosyltransferase (NadV) from Ralstonia solanacearum.

Will this lower the cost of production in the future?


Ph.D. student at Harvard Medical School, doing research on aging
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thomasdmd
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Re: Use bacteria to produce NMN

Post by thomasdmd » Fri Jul 31, 2020 2:45 am

Interesting. I wonder how NMN is currently made
NewLifeScience
Posts: 260
Joined: Thu Aug 22, 2019 4:17 pm

Re: Use bacteria to produce NMN

Post by NewLifeScience » Fri Jul 31, 2020 9:06 pm

Good question. essentially we generate NMN, or at least NAD+ by fasting. So i imagine it is either synthesized via a chemical reaction or grown from other life forms.

But... did it have to be E Coli??? :)
Taking:
Resveratrol 400mg since June 2019; 600mg since October 1; 800mg since January 2020
NMN Sublingual 250mg since june 2019 500mg since September 2019
NAD+ Nasal, appx 100mg per day since September 2019; 200mg per day beginning mid November
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