NMNWhich of the 7 NAD precursors do you supplement with?

Fred
Posts: 135
Joined: Tue Aug 13, 2019 3:17 pm
Location: Stockholm, Sweden

Which of the 7 NAD precursors do you supplement with?

Post by Fred » Sun Oct 06, 2019 5:19 am

To date there are 7 known NAD precursors. Which of them do you take? And at what dose of each?

I take 4 of the 7 NAD precursor molecules to feed the Preiss-Handler-, De novo-, salvage- and possibly alternative pathways to NAD-synthesis:
- nicotinic acid 250 mg
- niacinamide 25 mg (from multivitamin)
- l-tryptophan 2000 mg
- NMN 1000 mg.

The 7 NAD precursors (not ranked):

  • Nicotinic acid (niacin)
  • Nicotinamide (niacinamide)
  • L-tryptophan
  • NR (nicotinamide riboside)
  • NRH (reduced nicotinamide riboside)
  • NMN (nicotinamide mononucleotide)
  • NAR (nicotinic acid riboside)
Last edited by Fred on Mon Oct 07, 2019 2:04 pm, edited 1 time in total.


Fred
Registered dietitian, Sweden.
Vandevalk1
Posts: 184
Joined: Wed Aug 21, 2019 6:33 pm
Location: Port Elgin, ON, Canada

Re: Which of the 7 NAD precursors do you supplement with?

Post by Vandevalk1 » Mon Oct 07, 2019 10:20 am

I take:

NR - 250 mg
NMN - 1000mg

Additional

NAD+ - 125 mg
Resveratrol - 400mg
AUKC
Posts: 50
Joined: Tue Aug 20, 2019 8:05 pm

Re: Which of the 7 NAD precursors do you supplement with?

Post by AUKC » Mon Oct 07, 2019 7:27 pm

Did you both start on 1000mg?

And do you take the powder or pills of NMN?
Current Dosages:
200mg Resveratrol
625mg NMN
1000mg L-Arginine
CeeJayBee
Posts: 39
Joined: Thu Aug 22, 2019 4:19 pm

Re: Which of the 7 NAD precursors do you supplement with?

Post by CeeJayBee » Mon Oct 07, 2019 8:49 pm

Fred wrote:
Sun Oct 06, 2019 5:19 am
L-tryptophan
When you refer to L-tryptophan here, is this specifically L-tryptophan 5?
Fred
Posts: 135
Joined: Tue Aug 13, 2019 3:17 pm
Location: Stockholm, Sweden

Re: Which of the 7 NAD precursors do you supplement with?

Post by Fred » Mon Oct 07, 2019 11:09 pm

AUKC wrote:
Mon Oct 07, 2019 7:27 pm
Did you both start on 1000mg?

And do you take the powder or pills of NMN?
I started directly on 1000 mg NMN. The pills first and when they're done I'll try the powder.
Last edited by Fred on Tue Oct 08, 2019 3:33 am, edited 1 time in total.
Fred
Registered dietitian, Sweden.
Fred
Posts: 135
Joined: Tue Aug 13, 2019 3:17 pm
Location: Stockholm, Sweden

Re: Which of the 7 NAD precursors do you supplement with?

Post by Fred » Mon Oct 07, 2019 11:13 pm

CeeJayBee wrote:
Mon Oct 07, 2019 8:49 pm
Fred wrote:
Sun Oct 06, 2019 5:19 am
L-tryptophan
When you refer to L-tryptophan here, is this specifically L-tryptophan 5?
I refer to the essential amino acid l-tryptophan that replenishes NAD in the liver by De novo synthesis. L-tryptophan is l-tryptophan. There's no other version than the essential amino acid.

I'm not referring to the metabolite 5-htp (5-hydroxytryptophan), if that is what you meant by "l-tryptophan 5"?
Fred
Registered dietitian, Sweden.
Fred
Posts: 135
Joined: Tue Aug 13, 2019 3:17 pm
Location: Stockholm, Sweden

Re: Which of the 7 NAD precursors do you supplement with?

Post by Fred » Wed Oct 09, 2019 9:24 am

Thank you Vandevalk1 for contributing with your answer.
Fred
Registered dietitian, Sweden.
CeeJayBee
Posts: 39
Joined: Thu Aug 22, 2019 4:19 pm

Re: Which of the 7 NAD precursors do you supplement with?

Post by CeeJayBee » Wed Oct 09, 2019 8:40 pm

Fred wrote:
Mon Oct 07, 2019 11:13 pm
CeeJayBee wrote:
Mon Oct 07, 2019 8:49 pm
Fred wrote:
Sun Oct 06, 2019 5:19 am
L-tryptophan
When you refer to L-tryptophan here, is this specifically L-tryptophan 5?
I refer to the essential amino acid l-tryptophan that replenishes NAD in the liver by De novo synthesis. L-tryptophan is l-tryptophan. There's no other version than the essential amino acid.

I'm not referring to the metabolite 5-htp (5-hydroxytryptophan), if that is what you meant by "l-tryptophan 5"?
yes, i have been taking an SSRI since the 90s, which inhibits the reuptake of Serotonin. It's one of those cases where it is really hard to get off this medication even though the original depression that led me to get it has been manageable for a long time... i have wanted to experiment withL-tryptophan to gradually replace it... but this stuff is a bit over my head,
Fred
Posts: 135
Joined: Tue Aug 13, 2019 3:17 pm
Location: Stockholm, Sweden

Re: Which of the 7 NAD precursors do you supplement with?

Post by Fred » Thu Oct 10, 2019 3:13 am

CeeJayBee,

Serotonin syndrome has been reported with gram doses of TRP together with an SSRI. Have you looked into a very slow taper of 10% of your current dose every month? Staying on each lowered dose for 3-4 weeks seems to be the easiest way to readjust your brain to a "non-SSRI" state (if that is what you want of course).

If you´re already doing exercise or daily walking and taking a multivitamin, magnesium and fish oil then I would recommend starting l-tryptophan when you´re off the SSRI. There´s not very good evidence for l-tryptophan as a mono treatment for depression. A bit better evidence for 5-htp. But both beat placebo and I find TRP nice for sleep.
Fred
Registered dietitian, Sweden.
Newage
Posts: 297
Joined: Thu Aug 22, 2019 10:22 pm

Re: Which of the 7 NAD precursors do you supplement with?

Post by Newage » Thu Oct 10, 2019 3:38 am

Fred.
What are your views on dosing with Rhodiola Rosea ( standardised ) for treating mild to moderate depression.
May be an alternative for CeeJayBee ?
Post Reply Previous topicNext topic