AlbertY wrote: ↑
Mon Oct 21, 2019 1:20 pm
Drdavid wrote: ↑
Mon Oct 21, 2019 7:24 am
AlbertY wrote: ↑
Wed Oct 16, 2019 12:28 pm
These questions cannot be answered until large-scaled human trials have been done. But based on the current model of how NAD+ and sirtuin work, the answer to the first question is: unlikely. Based on the epigenetic theory of aging, aging is a result of the random events that happen after DNA damage that causes epigenetic landscape erosion. Maintain the sirtuin activity through NAD+ supplementation can help to maintain the epigenetic landscape, and thus slow down aging. As you can see, epigenetic landscape erosion is a kind of random, accumulative effect, so it is unlikely to be accelerated after stopping NAD+ supplementation.
For the second question, I don't know for NMN, but for most of the anti-aging interventions (rapamycin, acarbose, dietary restriction, hypoxia..), you will get a better effect if started treating the lab animal in an early stage of life; and they perform poorly if you started it at an old age. But it might not true for NMN, because the NAD+ level only drops down when you are older. It is possible that young people will get less benefit from it and thus make the outcomes similar between early-onset and late-onset NMN supplementation.
I agree and great explanation. Although epigenetic landscape erosion is random have you seen any changes with subjects that have been on some sort of epigenetic landscape erosion prevention plan?
Yes, DNA damage accelerate epigenetic landscape erosion. So avoid anything that could cause DNA damage as much as you can (e.g. X-ray, UV, alcohol etc). And to some extent NAD+ supplements works through maintaining the epigenetic landscape by activating Sirtuin.
So I guess if we took a large group of cath lab physicians and nurses and double blinded them we might be able to see if an erosion prevention plan actually works.