NMNImportant question regarding extended use of NMN or NR

drkris69
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Re: Important question regarding extended use of NMN or NR

Post by drkris69 » Wed Oct 16, 2019 3:50 pm

Well said...


canadahealthy
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Re: Important question regarding extended use of NMN or NR

Post by canadahealthy » Thu Oct 17, 2019 7:25 pm

it is an important question and hopefully these supplemental molecules get cheaper as time goes by.
so affordability does not become a factor in ceasing the supplements
AUKC
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Re: Important question regarding extended use of NMN or NR

Post by AUKC » Fri Oct 18, 2019 10:52 pm

drkris69 wrote:
Wed Oct 16, 2019 12:02 pm
QUESTION,....Have you been using Alive By Nature products this whole time?? Or were there different NMN, NAD+ products that you started with?
Regarding this, I did a lot of research before finding AliveByNature, as they kept popping up in threads/forums as a recommendation in a comment.

I haven't tried any other brands simply because of the quality I already get from this one
Current Dosages:
200mg Resveratrol
750mg NMN
1000mg L-Arginine
drkris69
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Re: Important question regarding extended use of NMN or NR

Post by drkris69 » Sat Oct 19, 2019 6:52 am

Sorry AUKC, my question was meant for Pickleball....I was curious if he used Alive by Nature's products during his clinical trial...
Drdavid
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Re: Important question regarding extended use of NMN or NR

Post by Drdavid » Mon Oct 21, 2019 7:24 am

AlbertY wrote:
Wed Oct 16, 2019 12:28 pm
These questions cannot be answered until large-scaled human trials have been done. But based on the current model of how NAD+ and sirtuin work, the answer to the first question is: unlikely. Based on the epigenetic theory of aging, aging is a result of the random events that happen after DNA damage that causes epigenetic landscape erosion. Maintain the sirtuin activity through NAD+ supplementation can help to maintain the epigenetic landscape, and thus slow down aging. As you can see, epigenetic landscape erosion is a kind of random, accumulative effect, so it is unlikely to be accelerated after stopping NAD+ supplementation.

For the second question, I don't know for NMN, but for most of the anti-aging interventions (rapamycin, acarbose, dietary restriction, hypoxia..), you will get a better effect if started treating the lab animal in an early stage of life; and they perform poorly if you started it at an old age. But it might not true for NMN, because the NAD+ level only drops down when you are older. It is possible that young people will get less benefit from it and thus make the outcomes similar between early-onset and late-onset NMN supplementation.
I agree and great explanation. Although epigenetic landscape erosion is random have you seen any changes with subjects that have been on some sort of epigenetic landscape erosion prevention plan?
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AlbertY
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Re: Important question regarding extended use of NMN or NR

Post by AlbertY » Mon Oct 21, 2019 1:20 pm

Drdavid wrote:
Mon Oct 21, 2019 7:24 am
AlbertY wrote:
Wed Oct 16, 2019 12:28 pm
These questions cannot be answered until large-scaled human trials have been done. But based on the current model of how NAD+ and sirtuin work, the answer to the first question is: unlikely. Based on the epigenetic theory of aging, aging is a result of the random events that happen after DNA damage that causes epigenetic landscape erosion. Maintain the sirtuin activity through NAD+ supplementation can help to maintain the epigenetic landscape, and thus slow down aging. As you can see, epigenetic landscape erosion is a kind of random, accumulative effect, so it is unlikely to be accelerated after stopping NAD+ supplementation.

For the second question, I don't know for NMN, but for most of the anti-aging interventions (rapamycin, acarbose, dietary restriction, hypoxia..), you will get a better effect if started treating the lab animal in an early stage of life; and they perform poorly if you started it at an old age. But it might not true for NMN, because the NAD+ level only drops down when you are older. It is possible that young people will get less benefit from it and thus make the outcomes similar between early-onset and late-onset NMN supplementation.
I agree and great explanation. Although epigenetic landscape erosion is random have you seen any changes with subjects that have been on some sort of epigenetic landscape erosion prevention plan?
Yes, DNA damage accelerate epigenetic landscape erosion. So avoid anything that could cause DNA damage as much as you can (e.g. X-ray, UV, alcohol etc). And to some extent NAD+ supplements works through maintaining the epigenetic landscape by activating Sirtuin.
Ph.D. student at Harvard Medical School, doing research on aging
drkris69
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Re: Important question regarding extended use of NMN or NR

Post by drkris69 » Mon Oct 21, 2019 1:45 pm

Just curious, anyone here try the new NMN-SL? And also do you guys prefer the powder or the pills.... 8-)
NewLifeScience
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Re: Important question regarding extended use of NMN or NR

Post by NewLifeScience » Tue Oct 22, 2019 10:47 am

drkris69 wrote:
Mon Oct 21, 2019 1:45 pm
Just curious, anyone here try the new NMN-SL? And also do you guys prefer the powder or the pills.... 8-)
I definitely prefer the pills. But i have no problem using the powder.

When i first heard of this stuff, it was the powder i was about to order before i discovered ABN products.
Taking:
Resveratrol 400mg since June 2019; 600mg since October 1
NMN Sublingual 250mg since june 2019 500mg since September 2019; 600mg since Dec 1, 2019
NAD+ Nasal, appx 100mg per day since September 2019; 200mg per day beginning mid November
drkris69
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Re: Important question regarding extended use of NMN or NR

Post by drkris69 » Tue Oct 22, 2019 10:54 am

I have the new NMN-SL now and the taste is different with the mannitol added. Its supposed to aid in digesting the NMN once in the gut. I believe also that the mannitol may help the NMN break thru the blood brain barrier. Ive read this somewhere and need to look this up to confirm.
Pickleball101
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Re: Important question regarding extended use of NMN or NR

Post by Pickleball101 » Fri Nov 29, 2019 9:23 pm

drkris69 wrote:
Wed Oct 16, 2019 12:02 pm
Wow Pickleball....Bravo and well done sir. I went from 500mg to 1g daily of NMN about a month ago. Im still monitoring my results form doubling my dose. Im blown away from you Picklball and your results. QUESTION,....Have you been using Alive By Nature products this whole time?? Or were there different NMN, NAD+ products that you started with?
Just saw your Question, regret the delay.
Two years ago I started taking BASIS and Resveratrol with some energy boost, but it wasn't until I switched to NMN last year that the real
effects starting showing up. I noticed my left elbow psoriasis disappeared so I mentioned this to another Pickleball player, who had been
fighting it all over his legs. One day, after not seeing him for months, he ran over, clean legged, and thanked me for telling him of NMN.
There are many other similar small changes, in myself and others... It really has an underlying progressive improvement to health, starting
at the cellular stage.
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