1. What happens if you suddenly stop taking it after using it for decades? Will all the gains revert and you will end up at your default age as if you never took those supplements? Maybe there is some sort of threshold on your cells and organs that prevents them from aging as long as there is enough nad+. Once we take away the nad+, it will all decay and go back to the age according to your current/low nad+ levels.
2. Lets say we have 2 twins. Both are 60 years old with the only difference between them being the fact, that one of them started taking nmn/nr at 50 years old and the other at 30 years old. Will the twin that took the supplement longer be in better shape, health and "younger"?
I am curious if the answer to those questions are already known or atleast there are some indicators that would give some clues.
And they've probably tried to test this in a micro world of mice who have shorter lifespans.
Interested to know if anyone has any links to some research that may be similar to his first question
I dont think it is related to those questions. We assume nmn makes you technically younger. What we are interested in is what happens if you stop taking it and what happens if you start when you are still young naturally.
Basically, my cells are older and have less memory to naturally regenerate when needed. NMN is the switch in ALL cells to turn on that process.
My levels were significantly less than that of a 21 year old, at 100%, so adding up to a gram a day of NMN restores older cells NMN level to 100%.
I've participated in this forums Clinical Trial offered last year to 40 athletes to determine what an increase in their dosage to these higher levels would be seen in their sport. Mine is Pickleball play. I went from a Low Intermediate to a mid Advanced level in 3 months, winning Silver in Tournament play against opponents 20 years my junior. Then I went back to 1/2 the dosage for the last year, of a total of 500 mg of NMN/NAD+ / day. I did feel a fall back to about mid range of my prior energy levels, but the effects of balancing my gut , glucose levels, same keto plan and intensive play has given me a sense of "wholeness". I'm been free from disease from 60-80 that kills most people, so my genes are good to go to 100+. NMN is the grease to get there with Pickleball. Without it I probably couldn't play.Ben
For the second question, I don't know for NMN, but for most of the anti-aging interventions (rapamycin, acarbose, dietary restriction, hypoxia..), you will get a better effect if started treating the lab animal in an early stage of life; and they perform poorly if you started it at an old age. But it might not true for NMN, because the NAD+ level only drops down when you are older. It is possible that young people will get less benefit from it and thus make the outcomes similar between early-onset and late-onset NMN supplementation.