FAQsWhat is the role of the enzyme Slc12a8 in NMN transportation?

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nettlesbe
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What is the role of the enzyme Slc12a8 in NMN transportation?

Post by nettlesbe » Fri Jul 26, 2019 3:14 pm

Research was published in January 2019 that found an enzyme named Slc12a8 that can transport a small quantity of Nicotinamide Mononucleotide (NMN) directly into some cells.

However, this enzyme is only prevalent in the small intestine of older, sicker animals and humans.
The Slc12a8 enzyme was just discovered because it plays a very minor role, and does not transport a large enough quantity of NMN to have been noticed earlier.

https://www.nature.com/articles/s42255-018-0009-4#Fig3