NAD+ OptimizersNicotinamide riboside

LucB
Posts: 3
Joined: Fri Nov 22, 2019 5:44 pm

Nicotinamide riboside

Post by LucB » Sun Nov 24, 2019 8:12 am

Research Paper
Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin resistant men
Ole L. Dollerup Sabina Chubanava Marianne Agerholm Stine D. Søndergård Ali Altıntaş Andreas B. Møller Kasper F. Høyer Steffen Ringgaard … See all authors
First published: 11 November 2019 https://doi.org/10.1113/JP278752
Edited by: Michael Hogan & Russell Hepple
Trial registration: clinicaltrials.gov: NCT02303483
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as https://doi.org/10.1113/JP278752


Drdavid
Posts: 712
Joined: Thu Aug 15, 2019 9:59 am

Re: Nicotinamide riboside

Post by Drdavid » Sun Nov 24, 2019 1:06 pm

This is an interesting study with interesting data. Although a small sample size and short term study the conclusion would be that NR at 1000mg BID did not alter mitochondrial respiration in the subset of the population. It appears that there where only two samples drawn from the participants. It would be interesting to know if more samples were taken if the data would change or remain along a fixed line. The second thing would be if the sample size is increased would the data change. Small sample size research can produce skewed data. Third, does the dosing recommendation matter? If dosing is adjusted do the results change even in this sample size. Fourth, are there other physiological changes that are occurring with NR supplementation that was not part of this research criteria or does NR supplementation just not provide any relevant physiological gains?
Thanks for sharing this!
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