Bioage TestingAnyone do methylation clock testing?

Deleted User 15772

Anyone do methylation clock testing?

Post by Deleted User 15772 » Wed Sep 18, 2019 1:00 pm

I became intrigued by methylation/ Horvath clock testing after reading David Sinclair’s new book. Has anyone tried it out? Seems like the main testing provider is: https://www.mydnage.com/


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jocko6889
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Re: Anyone do methylation clock testing?

Post by jocko6889 » Wed Sep 18, 2019 1:36 pm

Yes, I took the Mydnage.com test recently and am waiting on results. This would be my third bioage test. I've already taken the Insidetracker.com InnerAge blood test for 5 biomarkers of aging and the Teloyears.com test, which tests for average telomere length.
rhett
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Re: Anyone do methylation clock testing?

Post by rhett » Wed Sep 18, 2019 1:41 pm

Would love to hear how your test turns out. Was thinking about doing one myself but couldn't get a sense of whether it would be actually useful.
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jocko6889
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Re: Anyone do methylation clock testing?

Post by jocko6889 » Wed Sep 18, 2019 8:43 pm

Might be a few weeks but I'll post the results when I get them. My feeling is the amount of methylation on DNA is probably the truest test of your bioage.
Drdavid
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Re: Anyone do methylation clock testing?

Post by Drdavid » Thu Sep 19, 2019 10:05 pm

Jocko, would you mind expanding on the methylation concept of aging for the forum? This is an important topic that I think people need to hear about.
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Re: Anyone do methylation clock testing?

Post by jocko6889 » Fri Sep 20, 2019 6:23 pm

As we age, extraneous methylation forms on the DNA through smoking, too much sun, poor diet, lack of exercise, etc. clouding the original information, like scratches on a CD. Over time the cell may not resemble, say a liver cell anymore and may look more like a mixture of difference cells. Testing the amount of methylation is like seeing how many scratches are on the CD, finding out how well your body can still play the original music as intended.
rhett
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Re: Anyone do methylation clock testing?

Post by rhett » Fri Sep 20, 2019 9:27 pm

Something that was a realization for me was that every cell in your body has the exact same DNA.

But the reason a heart cell is a heart cell and not a skin cell is due to methylation.

Methylation is what tells a cell to express certain genes while keeping others silent.

There are also variations of the type of heart cell characteristics a given person's cells can have, also due to methylation.

Over time, methylation gets corrupted. You start getting all kinds of weird errors where incorrect genes are getting turned on and correct genes are getting turned off. Over time, your heart cells are forgetting how to be good heart cells. And all the other cells too.

Horvath figured out how to measure the corruption in the methylation information and from that, figure out your age.
Drdavid
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Re: Anyone do methylation clock testing?

Post by Drdavid » Fri Sep 20, 2019 9:45 pm

All this talk of methylation and aging made me think of this article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482848/
It is a great read for anyone studying antiaging
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