LongevityAlpha-ketoglutarate, a naturally occuring metabolite, extends lifespan and compresses morbidity in aging mice

Fred
Posts: 281
Joined: Tue Aug 13, 2019 3:17 pm
Location: Stockholm, Sweden

Alpha-ketoglutarate, a naturally occuring metabolite, extends lifespan and compresses morbidity in aging mice

Post by Fred » Sun Nov 10, 2019 12:30 pm

I believe I´ve seen AKG in some workout supplement formulas?

Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses
morbidity in aging mice


https://www.biorxiv.org/content/biorxiv ... 7.full.pdf
Here we show that alpha-ketoglutarate (delivered in the form of a Calcium salt, CaAKG), a key metabolite in tricarboxylic (TCA) cycle that is reported to extend lifespan in worms , can significantly extend lifespan and healthspan in mice.

AKG is involved in various fundamental processes including collagen synthesis and epigenetic changes. Due to its broad roles in multiple biological processes, AKG has been a subject of interest for researchers in various fields. AKG also influences several age-related processes, including stem cell proliferation and osteoporosis.

To determine its role in mammalian aging, we administered CaAKG in 18 months old mice and determined its effect on the onset of frailty and survival, discovering that the metabolite promotes longer, healthier life associated with a decrease in levels of inflammatory factors. Interestingly the reduction in frailty was more dramatic than the increase in lifespan, leading us to propose that CaAKG compresses morbidity.


Fred
Registered dietitian, Sweden.