LongevityBerberine ameliorates cellular senescence and extends the lifespan of mice

Fred
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Location: Stockholm, Sweden

Berberine ameliorates cellular senescence and extends the lifespan of mice

Post by Fred » Sun Dec 01, 2019 9:32 am

Abstract
Although aging and senescence have been extensively studied in the past few decades, however, there is lack of clinical treatment available for anti‐aging.

This study presents the effects of berberine (BBR) on the aging process resulting in a promising extension of lifespan in model organisms.

BBR extended the replicative lifespan, improved the morphology, and boosted rejuvenation markers of replicative senescence in human fetal lung diploid fibroblasts (2BS and WI38). BBR also rescued senescent cells with late population doubling (PD).

Furthermore, the senescence‐associated β‐galactosidase (SA‐β‐gal)‐positive cell rates of late PD cells grown in the BBR‐containing medium were ~72% lower than those of control cells, and its morphology resembled that of young cells.

Mechanistically, BBR improved cell growth and proliferation by promoting entry of cell cycles from the G0 or G1 phase to S/G2‐M phase.

Most importantly, BBR extended the lifespan of chemotherapy‐treated mice and naturally aged mice by ~52% and ~16.49%, respectively. The residual lifespan of the naturally aged mice was extended by 80%, from 85.5 days to 154 days.

The oral administration of BBR in mice resulted in significantly improved health span, fur density, and behavioral activity.

Therefore, BBR may be an ideal candidate for the development of an anti‐aging medicine.

https://onlinelibrary.wiley.com/doi/ful ... acel.13060


Fred
Registered dietitian, Sweden.
NewLifeScience
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Re: Berberine ameliorates cellular senescence and extends the lifespan of mice

Post by NewLifeScience » Sun Dec 01, 2019 8:55 pm

Wow, so this is great news... all this and its potential to behave like metformin?

Was this an outcome you already suspected, Fred?
Taking:
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Fred
Posts: 274
Joined: Tue Aug 13, 2019 3:17 pm
Location: Stockholm, Sweden

Re: Berberine ameliorates cellular senescence and extends the lifespan of mice

Post by Fred » Sun Dec 01, 2019 10:36 pm

NewLifeScience wrote:
Sun Dec 01, 2019 8:55 pm
Wow, so this is great news... all this and its potential to behave like metformin?

Was this an outcome you already suspected, Fred?
Well, what berberine can do in mice is interesting but I only care for what it may do for humans. These results needs to be repeated in another trial to be validated.

So metformin has 50 years of human data and it makes diabetics live longer than non-diabetics. Berberine needs more human data to discern effects and negative side effects.
Fred
Registered dietitian, Sweden.
drkris69
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Joined: Tue Aug 20, 2019 2:41 pm

Re: Berberine ameliorates cellular senescence and extends the lifespan of mice

Post by drkris69 » Mon Dec 02, 2019 10:01 am

Great article thanks.
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ALIVEBYNATURE
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Re: Berberine ameliorates cellular senescence and extends the lifespan of mice

Post by ALIVEBYNATURE » Mon Dec 02, 2019 2:37 pm

Berberine and Metformin have similar results for many ailments even though they work through different pathways.

The common denominator is, both lower blood glucose and insulin response.

It's becoming more clear all the time these are main drivers of inflammation and chronic disease, so it's not surprising both extend lifespan.
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