LongevityWARNING: NDMA in metformin

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AlbertY
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Location: Boston, MA

WARNING: NDMA in metformin

Post by AlbertY » Wed May 27, 2020 3:57 pm

Preprint published yesterday:
Recent reports of metformin drug products contaminated with unacceptable levels of the probable human carcinogen N-Nitrosodimethylamine (NDMA) prompted a national sampling of post-market metformin drug products. To most broadly sample the market and minimize supply chain bias, metformin medication samples were crowdsourced directly from individuals across many states in the United States. 128 samples were received, and liquid chromatography-high resolution mass spectrometry tests for a panel of nitrosamines revealed significant levels of NDMA that trend with labeling company. 42% of all medication samples contained detectable levels of NDMA and, when scaled to maximum daily tablet dose, 36% of all medication samples contained NDMA levels exceeding the FDA daily acceptable intake limit. The highest NDMA detection from the tested samples was 1565 ng per tablet, which, when commonly taken four times a day, is 65 times the United States Food and Drug Administration (FDA) acceptable daily intake limit. Results underscore the need for immediate product recalls of tainted medications and an overall investigation of metformin manufacturing practices.
https://www.medrxiv.org/content/10.1101 ... 20110635v1


Ph.D. student at Harvard Medical School, doing research on aging
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AlbertY
Posts: 129
Joined: Mon Aug 12, 2019 4:01 pm
Location: Boston, MA

Re: WARNING: NDMA in metformin

Post by AlbertY » Wed May 27, 2020 3:58 pm

Check the companys here
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Ph.D. student at Harvard Medical School, doing research on aging
Drdavid
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Joined: Thu Aug 15, 2019 9:59 am

Re: WARNING: NDMA in metformin

Post by Drdavid » Wed May 27, 2020 4:10 pm

This is crazy! With the amount of people that are on this drug I am amazed that this was not caught sooner.
OzSport
Posts: 232
Joined: Wed Aug 21, 2019 5:08 am

Re: WARNING: NDMA in metformin

Post by OzSport » Thu May 28, 2020 2:52 am

Yikes! :shock: I know a person who was taking metformin and they mentioned something like this off the cuff, but I didn't realize there was an actual study on it, wow!
drkris69
Posts: 477
Joined: Tue Aug 20, 2019 2:41 pm

Re: WARNING: NDMA in metformin

Post by drkris69 » Fri May 29, 2020 11:20 am

Wow great find AlbertY. That is crazy is right!
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