LongevityMetformin Dosage?

Green2201
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Joined: Mon Feb 17, 2020 10:07 am

Metformin Dosage?

Post by Green2201 » Mon Feb 17, 2020 10:21 am

I recently received Metformin and am currently taking 250mg twice a day before my largest meals. My wife is doing the same. I’m wondering how much to take. Is it based on weight/sex/age/body composition? I kind of like the idea of using the minimum effective dose, but don’t want to take so little that it doesn’t work. How much is everyone taking and why?


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jocko6889
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Re: Metformin Dosage?

Post by jocko6889 » Mon Feb 17, 2020 1:26 pm

Green2201 wrote:
Mon Feb 17, 2020 10:21 am
I recently received Metformin and am currently taking 250mg twice a day before my largest meals. My wife is doing the same. I’m wondering how much to take. Is it based on weight/sex/age/body composition? I kind of like the idea of using the minimum effective dose, but don’t want to take so little that it doesn’t work. How much is everyone taking and why?
The usual dose is 500mg twice per day initially (a week or two usually), increasing to 1,000mg twice per day if you can tolerate it. It's not really based on weight/sex/age, etc. Taking it with meals helps. Metformin has been around for decades and is extremely safe.
drkris69
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Re: Metformin Dosage?

Post by drkris69 » Mon Feb 17, 2020 2:05 pm

I agree with jocko, but yes I would start with 500mg 2xday. Increase to 1g 2xday if you can tolerate it. I would always ask your provider if they are okay with the dose as well. Just to let you know, Dr. Sinclair takes 1g per day which seems to be a starting dose for most.
drkris69
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Re: Metformin Dosage?

Post by drkris69 » Mon Feb 17, 2020 2:11 pm

Just be cautious and watch out for nausea as this could happen if you jump up too fast. Always take with food.
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