Miscellaneous TopicsDiabetes drug has unexpected, broad implications for healthy aging

Fred

Diabetes drug has unexpected, broad implications for healthy aging

Post by Fred » Sun Dec 08, 2019 12:53 pm

"Scientists discover multiple mechanisms at work in widely-used diabetes drug metformin

LA JOLLA—Metformin is the most commonly prescribed type 2 diabetes drug, yet scientists still do not fully know how it works to control blood sugar levels.

In a collaborative effort, researchers from the Salk Institute, The Scripps Research Institute and Weill Cornell Medical College have used a novel technology to investigate why it functions so well.

The findings, which identified a surprising number of biochemical “switches” for various cellular processes, could also explain why metformin has been shown to extend health span and life span in recent studies. The work was published in Cell Reports on December 3, 2019.

“These results provide us with new avenues to explore in order to understand how metformin works as a diabetes drug, along with its health-span-extending effects,” says Professor Reuben Shaw, co-corresponding author of the paper and the director of Salk’s NCI-designated Cancer Center. “These are pathways that neither we, nor anyone else, would have imagined.”

Previously, the only biochemical pathway that was known to be activated by metformin was the AMPK pathway, which Shaw discovered stalls cell growth and changes metabolism when nutrients are scarce, as can occur in cancer. But the scientists believed more pathways than AMPK might be involved.

The scientists developed a novel screening platform to examine kinases, the proteins that transfer phosphate groups, which are critical on/off switches in cells and can be rapidly flipped by metformin. Using this technology, the researchers were able to decode hundreds of regulatory “switch-flipping” events that could affect healthy aging."
“The results broaden our understanding of how metformin induces a mild stress that triggers sensors to restore metabolic balance, explaining some of the benefits previously reported such as extended healthy aging in model organisms taking metformin. The big questions now are what targets of metformin can benefit the health of all individuals, not just type 2 diabetics.”
https://www.salk.edu/news-release/diabe ... thy-aging/
Last edited by Fred on Sun Dec 08, 2019 10:41 pm, edited 1 time in total.


Drdavid
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Re: Diabetes drug has unexpected, broad implications for healthy aging

Post by Drdavid » Sun Dec 08, 2019 8:32 pm

This is fascinating! A drug that we have used since 1995 and still have no clear concept of how it really works. Now researchers find that it may provide a beneficial key in longevity. Thanks for the research
drkris69
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Re: Diabetes drug has unexpected, broad implications for healthy aging

Post by drkris69 » Mon Dec 09, 2019 1:55 pm

Thanks Fred, what a great report on Metformin and the benefits that it brings to the longevity arena!
Fred

Re: Diabetes drug has unexpected, broad implications for healthy aging

Post by Fred » Mon Dec 09, 2019 2:29 pm

It is truly an interesting drug. I do hope the human TAME-trial in healthy persons will go well. We'll know in a couple of years.
Fred

Re: Diabetes drug has unexpected, broad implications for healthy aging

Post by Fred » Tue Dec 10, 2019 12:44 am

Appetite supression via a protein called GDF15 also. Pop-science article below with link to the scientific article.

https://scitechdaily.com/secret-behind- ... -revealed/
Glaud
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Re: Diabetes drug has unexpected, broad implications for healthy aging

Post by Glaud » Mon Feb 03, 2020 9:25 am

Thank you this is interesting information.
drkris69
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Re: Diabetes drug has unexpected, broad implications for healthy aging

Post by drkris69 » Tue Feb 04, 2020 9:11 am

More reason to get your MD to write Metformin for you. :D
Newage
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Re: Diabetes drug has unexpected, broad implications for healthy aging

Post by Newage » Tue Feb 04, 2020 3:49 pm

drkris69 wrote:
Tue Feb 04, 2020 9:11 am
More reason to get your MD to write Metformin for you. :D
Not all that easy in Australia drkris69.
We are a long way behind with acceptance from the average GP.
Trying to source one out for Metformin at the moment..🤔
drkris69
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Re: Diabetes drug has unexpected, broad implications for healthy aging

Post by drkris69 » Wed Feb 05, 2020 7:55 am

Yeah I know, I feel for you guys Newage....
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AlbertY
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Re: Diabetes drug has unexpected, broad implications for healthy aging

Post by AlbertY » Wed Feb 05, 2020 6:40 pm

Always glad to hear any news about metformin as anti-aging drug
Ph.D. student at Harvard Medical School, doing research on aging
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