NMNNMN-study: NAD is essential for fatburning without exercise (thermogenesis)

Fred
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Location: Stockholm, Sweden

NMN-study: NAD is essential for fatburning without exercise (thermogenesis)

Post by Fred » Sat Nov 09, 2019 2:56 am

This study was published in PNAS Nov 6 2019.

They used mice modified to lack NAMPT in either brown or both brown and white adipose tissue. But since NAMPT-activity decreases with age, NAD-repletion may bolster downregulated whole-body energy metabolism via enhanced thermogenesis and lipolytic effects of fasting/CR, is my interpretation.

They administered NMN in drinking water at the approximate dose of 500 to 1000 mg/kg of body weight, to mice for up to 8 weeks.

Non-shivering thermogenesis accounts for 20% of all the energy you burn in a day (B. Cannon, J. Nedergaard, Brown adipose tissue: Function and physiological significance. Physiol. Rev. 84, 277–359 (2004)). Keeping it high is important in obesitas prevention.

"Adipose tissue NAD+ biosynthesis is required for regulating adaptive thermogenesis and whole-body energy homeostasis in mice"

Thermogenesis is a fundamental aspect of energy homeostasis. Here, we present evidence that adipose tissue NAD + metabolism is essential for thermogenesis.

We found cold exposure activates NAD + biosynthesis mediated by a rate-limiting enzyme, NAMPT, in mouse and human brown adipose tissue (BAT). Loss of NAMPT impairs the gene programs involved in thermogenesis and mitochondrial function in BAT.

Mice lacking NAMPT in both BAT and white adipose tissue (WAT) but not in BAT alone have impaired thermogenic responses to cold exposure, fasting, and β-adrenergic stimulation.

In WAT, NAMPT deletion decreases adrenergic-mediated lipolysis through inactivation of caveolin-1, which likely impairs whole-body thermogenesis. Nicotinamide mononucleotide administration normalized these metabolic derangements.

These findings demonstrate the importance of adipose tissue NAD + biology in energy metabolism.

AND

Taken together, these findings support the notion that NAD+ deficiency in WAT has important effects on whole-body metabolic function, particularly in people with obesity and older adults.

In conclusion, our data demonstrate that NAD+ is an essential regulator of adipose tissue metabolism and thermogenesis and illustrate the importance of adipocytes in regulating whole-body energy homeostasis. The current commercial availability and increasing popularity of NAD+ boosters, such as NR and NMN, make it particularly important to further evaluate the translational potential of these experimental findings in rodents and cell systems to people and to determine whether NAD+ is a promising molecular target for enhancing adipose tissue function and whole-body energy homeostasis.
https://sci-hub.se/https%3A%2F%2Fwww.pn ... 17116.long
Last edited by Fred on Sun Nov 10, 2019 11:45 am, edited 1 time in total.


Fred
Registered dietitian, Sweden.
Drdavid
Posts: 309
Joined: Thu Aug 15, 2019 9:59 am

Re: NMN-study: NAD is essential for fatburning without exercise (thermogenesis)

Post by Drdavid » Sun Nov 10, 2019 11:06 am

Fred thank you for linking these articles. These are very important points to consider when talking about weight loss and NAD. Brown fat has been a very interesting topic to read about over the last few years. We seem to understand more about why and how then before.
AUKC
Posts: 81
Joined: Tue Aug 20, 2019 8:05 pm

Re: NMN-study: NAD is essential for fatburning without exercise (thermogenesis)

Post by AUKC » Mon Nov 11, 2019 9:29 am

Perfect, dont need to work out anymore :D NAD got me covered!

Jokes aside, looks like it will be great to compare any bodily changes during my maintenance period
Current Dosages:
200mg Resveratrol
750mg NMN
1000mg L-Arginine
CeeJayBee
Posts: 56
Joined: Thu Aug 22, 2019 4:19 pm

Re: NMN-study: NAD is essential for fatburning without exercise (thermogenesis)

Post by CeeJayBee » Fri Nov 15, 2019 9:18 pm

I wonder if taking it WITH fat burning exercise produces more results than the two separately.

Or even producing the sum of both, greatly enhances your exercises.
CeeJayBee
Posts: 56
Joined: Thu Aug 22, 2019 4:19 pm

Re: NMN-study: NAD is essential for fatburning without exercise (thermogenesis)

Post by CeeJayBee » Fri Nov 15, 2019 9:19 pm

Fred wrote:
Sat Nov 09, 2019 2:56 am
Non-shivering thermogenesis
I think i want to start a band with this name. :D
Fred
Posts: 230
Joined: Tue Aug 13, 2019 3:17 pm
Location: Stockholm, Sweden

Re: NMN-study: NAD is essential for fatburning without exercise (thermogenesis)

Post by Fred » Sat Nov 16, 2019 12:01 am

CeeJayBee wrote:
Fri Nov 15, 2019 9:19 pm
Fred wrote:
Sat Nov 09, 2019 2:56 am
Non-shivering thermogenesis
I think i want to start a band with this name. :D
A bit long perhaps but THERMOGENESIS do sound like a hair-metal band 🤘
Fred
Registered dietitian, Sweden.
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