NAD+link NAD+ to the ten hallmarks of brain aging

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AlbertY
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link NAD+ to the ten hallmarks of brain aging

Post by AlbertY » Sat Nov 09, 2019 11:13 am

Lautrup et al. link NAD+ to the ten hallmarks of brain aging, summarize the effects of NAD+ augmentation on brain disorders, and point to NAD+-based clinical trials and future perspectives.

https://www.sciencedirect.com/science/a ... 3119305029

NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging findings that reveal key roles for NAD+ and related metabolites in the adaptation of neurons to a wide range of physiological stressors and in counteracting processes in neurodegenerative diseases, such as those occurring in Alzheimer’s, Parkinson’s, and Huntington diseases, and amyotrophic lateral sclerosis. Advances in understanding the molecular and cellular mechanisms of NAD+-based neuronal resilience will lead to novel approaches for facilitating healthy brain aging and for the treatment of a range of neurological disorders.


Ph.D. student at Harvard Medical School, doing research on aging