Spermidine is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy. External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice.
In humans, spermidine levels decline with aging, and a possible connection between reduced endogenous spermidine concentrations and age-related deterioration has been suggested.
Recent epidemiological data support this notion, showing that an increased uptake of this polyamine with spermidine-rich food diminishes overall mortality associated with cardiovascular diseases and cancer.
Here, we discuss nutritional and other possible routes to counteract the age-mediated decline of spermidine levels.
Spermidine-rich food items comprise unprocessed plant-derived foods including:
- wheat germ, cauliflower and broccoli, shitake mushrooms, fresh green pepper, the durian fruit and amaranth grain
Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?
https://www.tandfonline.com/doi/full/10 ... src=recsys